Scientists discover how T-cells cause damage to the brain

[MSUK]

Using a mouse model of human multiple sclerosis (MS), scientists have discovered how T-cells can easily damage the brain...Read more - http://www.ms-uk.org/scientists-discove ... ain-210317

[Scott1]

"Scientists conducting the “EB12 is highly expressed in multiple sclerosis lesions and promotes early CNS migration of encephalitogenic CD4 T-cells” study have discovered a protein on the surface of T-cells, called EB12, which is essential to penetration. EB12, also known as GPR183 (Epstein-Barr virus-induced G protein-coupled receptor 2) works as a receptor for another protein, a ligand known as 7a,25-dihydroxycholestrol."

This actually ties a lot of different ideas together!

[frodo]

As always, when they speak about T-cells in MS they mean EAE. They have cured EAE again.

In MS there is a clear problem with B-cells, which are not involved in EAE. Until they get a proper animal model of B-cells they should stop trying absurd experiments that have nothing to do with MS. They create noise instead of information.