has anybody heard about Bryostatin?

If it's on your mind and it has to do with multiple sclerosis in any way, post it here.
Post Reply
User avatar
frodo
Family Elder
Posts: 1344
Joined: Wed Dec 02, 2009 3:00 pm
Contact:

has anybody heard about Bryostatin?

Post by frodo » Wed May 30, 2018 10:41 pm

It seems that it is a new drug on trials. Has anybody tried it?

Bryostatin-1 as a macrolide and marine natural product has been selected as a therapeutic choice. Studies indicate that Bryostatin-1 has anti-inflammatory and antioxidant properties and decreases MMPs level and BBB damage. Furthermore, Bryostatin-1 has a neuroprotective effect and promotes neurogenesis and differentiation of oligodendrocyte progenitor stem cells as a critical step for remyelination/ myelogenesis. Based on these properties, we hypothesized here that Bryostatin-1 is an effective treatment in multiple sclerosis.

https://www.frontiersin.org/articles/10 ... 5/abstract

User avatar
NHE
Volunteer Moderator
Posts: 5304
Joined: Sat Nov 20, 2004 3:00 pm
Contact:

Re: has anybody heard about Bryostatin?

Post by NHE » Thu May 30, 2019 12:57 pm

Bryostatin-1 as a potential treatment for MS, Alzheimer's and other diseases is being developed by Neurotrope, https://neurotrope.com/.

User avatar
zen2010
Family Elder
Posts: 218
Joined: Mon Mar 15, 2010 3:00 pm
Location: Villeurbanne, France

Re: has anybody heard about Bryostatin?

Post by zen2010 » Mon Jun 03, 2019 6:09 am

In the end, to the best of our knowledge, the majority of studies about the effects of Bryostatin-1 are on the cellular level. Therefore, it is necessary to focus on the molecular events occurred after treatment of the cells with Bryostatin-1 in the future studies
It will take many years before getting any result...

User avatar
NHE
Volunteer Moderator
Posts: 5304
Joined: Sat Nov 20, 2004 3:00 pm
Contact:

Re: has anybody heard about Bryostatin?

Post by NHE » Mon Sep 09, 2019 11:33 pm

zen2010 wrote:
Mon Jun 03, 2019 6:09 am
In the end, to the best of our knowledge, the majority of studies about the effects of Bryostatin-1 are on the cellular level. Therefore, it is necessary to focus on the molecular events occurred after treatment of the cells with Bryostatin-1 in the future studies
It will take many years before getting any result...
Neurotrope's stock drops 77% on Sep 9, 2019 due to their phase II trial for Alzheimer's failing to achieve statistical significance.

https://www.cnn.com/business/newsfeeds/ ... 64253.html

Maybe they'll focus some of their work on MS now.

Anonymoose
Family Elder
Posts: 1155
Joined: Tue Oct 09, 2012 6:33 am

Re: has anybody heard about Bryostatin?

Post by Anonymoose » Tue Sep 10, 2019 6:41 am

Noticed this conflict in contents of “55 ways...myelin” post yesterday. Statins negatively impact myelination?? Link to 2008 study abstract referenced in that blog post.

https://www.ncbi.nlm.nih.gov/m/pubmed/19074034/

User avatar
NHE
Volunteer Moderator
Posts: 5304
Joined: Sat Nov 20, 2004 3:00 pm
Contact:

Re: has anybody heard about Bryostatin?

Post by NHE » Tue Sep 10, 2019 7:05 am

Anonymoose wrote:
Tue Sep 10, 2019 6:41 am
Noticed this conflict in contents of “55 ways...myelin” post yesterday. Statins negatively impact myelination?? Link to 2008 study abstract referenced in that blog post.

https://www.ncbi.nlm.nih.gov/m/pubmed/19074034/
I'm not sure why bryostatin carries the statin name as a suffix. However, the two molecules have significantly different structures and likely have different biochemical activity.

Bryostatin:

Image


Statin:

Image

Anonymoose
Family Elder
Posts: 1155
Joined: Tue Oct 09, 2012 6:33 am

Re: has anybody heard about Bryostatin?

Post by Anonymoose » Wed Sep 11, 2019 7:36 am

Doh! I automatically sighed and thought of old MS news and beating dead horses when I saw “statin.” I guess I’d better temper my cynicism w MS research or I might miss something good. Didn’t in this case though!

Post Reply
  • Similar Topics
    Replies
    Views
    Last post
  • has anyone heard of Digestacure ??
    by Youarethecure » Wed Jun 05, 2019 2:05 pm » in General Discussion
    4 Replies
    248 Views
    Last post by NHE
    Thu Jun 06, 2019 4:07 pm
  • Has anybody heard of Prohep?
    by frodo » Wed Oct 31, 2018 12:26 am » in Diet
    2 Replies
    982 Views
    Last post by frodo
    Wed Nov 07, 2018 6:19 am