Gilenya patients fail to develop an immune response following vaccination

Gilenya, or Fingolimod, is the first approved oral disease modifying drug for MS.
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dreddk
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Gilenya patients fail to develop an immune response following vaccination

Post by dreddk »

One to watch - study indicates that those on Gilenya do not elicit an immune response following dose of Pfizer vaccine. Authors recommend not giving dose to people taking Gilenya.

https://journals.sagepub.com/doi/full/1 ... 4211012835

There was a response from other MS researchers critical of their recommendation not to give the vaccine to those on Gilenya

https://journals.sagepub.com/doi/10.117 ... articles.2

And the authors reply to the criticism

https://journals.sagepub.com/doi/10.117 ... articles.1

I can't see any negatives to getting Vaccinated but appears the effectiveness may be severly impaired.
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NHE
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Re: Gilenya patients fail to develop an immune response following vaccination

Post by NHE »

Thanks for posting.
dreddk wrote: Sun Feb 12, 2017 9:11 pmApologies for late reply! My wife is a school teacher, switched to gilenya two years ago after developing antibodies to tysabri. No side effects at all, no relapses since starting on it. Good luck!
Is your wife still using Gilenya? How is she doing?
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dreddk
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Re: Gilenya patients fail to develop an immune response following vaccination

Post by dreddk »

Hi NHE,

Still on Gilenya- her lymphocytes dropped very low 18 months ago so now she takes every second day which seems to keep the count high enough to keep her Neuro happy.

She’s been largely symptom free for 8 years (touch wood) so nothing but good things to say about Gilenya.

Cheers
D
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NHE
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Re: Gilenya patients fail to develop an immune response following vaccination

Post by NHE »

Hi Dreddk,
That's good to hear. How long has she had MS?
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dreddk
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Re: Gilenya patients fail to develop an immune response following vaccination

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Diagnosed 14 years ago, with symptoms for around 18 years. No treatment at first, then Tysabri then Gilenya.
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gibbledygook
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Re: Gilenya patients fail to develop an immune response following vaccination

Post by gibbledygook »

I had my 2nd Astra Zeneca jab in june 21 and had my antibodies tested 2 weeks ago. I have antibodies to the Astra zeneca vax…fwiw.
3 years antibiotics, 06/09 bilateral jug stents at C1, 05/11 ballooning of both jug valves, 07/12 stenting of renal vein, azygos & jug valve ballooning,
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