Statin use is linked to type II diabetes

Discussion of statins (Lipitor, Zocor, etc.) in the treatment of MS.
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NHE
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Statin use is linked to type II diabetes

Post by NHE »

Statins Cause Diabetes: The Link Just Got Stronger!
https://www.peoplespharmacy.com/2019/03 ... -stronger/


Associations of statin use with glycaemic traits and incident type 2 diabetes
https://bpspubs.onlinelibrary.wiley.com ... /bcp.13898

Aims: There are several epidemiological studies on the association between statins and incident diabetes, but most of them lack details. In this study, we aimed to investigate the association of statin use with glycaemic traits and incident type 2 diabetes.

Methods: Using the prospective population‐based Rotterdam Study, we included 9535 individuals free from diabetes at baseline (>45 years) during the study period between 1997 and 2012. Linear regression analysis was applied to examine the cross‐sectional associations between statin use and glycaemic traits including fasting blood serum of glucose and insulin concentrations, and insulin resistance. In a longitudinal follow‐up study, we applied a Cox regression analysis to determine adjusted hazard ratios (HR) for incident type 2 diabetes in new users of statins.

Results: The mean age at baseline was 64.3 ± 10.1 years and 41.7% were men. In the fully adjusted model, compared to never users of statins, baseline use of statins was associated with higher concentrations of serum fasting insulin (β = 0.07; 95% CI: 0.02–0.13) and insulin resistance (β = 0.09; 95% CI: 0.03–0.14). Ever use of statins was associated with a 38% higher risk of incident type 2 diabetes (HR = 1.38; 95% CI: 1.09–1.74). This risk was more prominent in subjects with impaired glucose homeostasis and in overweight/obese individuals.

Conclusions: Individuals using statins may be at higher risk for hyperglycaemia, insulin resistance and eventually type 2 diabetes. Rigorous preventive strategies such as glucose control and weight reduction in patients when initiating statin therapy might help minimize the risk of diabetes.
NHE
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Re: Statin use is linked to type II diabetes

Post by NHE »

What Your Doctor May Not Tell You About the Statin and Diabetes Connection

https://www.peoplespharmacy.com/article ... onnection/

Many cardiologists were reluctant to acknowledge the statin and diabetes connection. Now each patient deserves to weigh the risks.

Statins such as atorvastatin or simvastatin are extremely effective at lowering circulating levels of cholesterol. Doctors prescribe them to reduce the chance that a patient will have a heart attack or a stroke. Very often, though, doctors don’t have good answer for people who are worried about the statin and diabetes connection uncovered in studies. How can you weigh the risks?
ElliotB
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Re: Statin use is linked to type II diabetes

Post by ElliotB »

Interesting finding. Statins have so many bad side effects. I tried several and within a day or two had excruciating pain and could barely walk because of the intense pain and had to stop immediately.

I now use an injectable called Repatha which immediately lowered my cholesterol without any side effects. An interesting drug.

A couple of interesting facts about cholesterol. There appears not to be a correlation between high cholesterol and heart attacks contrary to popular beliefs.

Perhaps the most interesting thing I have found out recently about cholesterol is its very important roll in myelin repair. So I face dilemma of whether to stay on Repatha or not.
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