The MS prodrome could be around 6 years

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frodo
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The MS prodrome could be around 6 years

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The MS prodrome (since the beginning of the underlying disease to the RIS) could be around 6 years.

Preventing disease progression in multiple sclerosis

https://genomemedicine.biomedcentral.co ... 22-01044-8

Excerpt

Insights gained from large international real-world cohorts demonstrate that early efficacious treatment is crucial for the long-term outcome of MS patients.

However, there is increasing evidence of substantial neuronal damage already occurring in presymptomatic patients (e.g., in patients with abnormalities in magnetic resonance imaging (MRI) without clinical symptoms, the so-called radiologically isolated syndrome) and even in a prodromal phase that precedes the detection of first abnormalities in MRI.

For example, increased neurofilament light chain (NfL) levels, a biomarker of neuronal damage, have been detected in blood samples obtained from seemingly healthy US military personnel up to 6 years before they presented with the first clinical episode of MS

Moreover, large-scale cognitive testing of more than 20,000 individuals revealed that men later receiving a diagnosis of MS had lower cognitive scores than healthy controls up to 2 years before their first clinical event

These observations highlight that delaying treatment initiation until clinical disease onset might be too late for preventing long-term progression of physical and cognitive impairment.

Thus, strategies that enable the identification of individuals at risk and of patients with presymptomatic MS along with the initiation of preventive measures (e.g., modification of known risk factors like smoking and obesity, disease-specific education, and early detection examinations) might be a key to overcoming MS progression.
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