PM10

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Petr75
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Re: PM10

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2022 Nov 30
Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark
Long-term air pollution exposure and Parkinson's disease mortality in a large pooled European cohort: An ELAPSE study
https://pubmed.ncbi.nlm.nih.gov/36516478/

Abstract

Background: The link between exposure to ambient air pollution and mortality from cardiorespiratory diseases is well established, while evidence on neurodegenerative disorders including Parkinson's Disease (PD) remains limited.

Objective: We examined the association between long-term exposure to ambient air pollution and PD mortality in seven European cohorts.

Methods: Within the project 'Effects of Low-Level Air Pollution: A Study in Europe' (ELAPSE), we pooled data from seven cohorts among six European countries. Annual mean residential concentrations of fine particulate matter (PM2.5), nitrogen dioxide (NO2), black carbon (BC), and ozone (O3), as well as 8 PM2.5 components (copper, iron, potassium, nickel, sulphur, silicon, vanadium, zinc), for 2010 were estimated using Europe-wide hybrid land use regression models. PD mortality was defined as underlying cause of death being either PD, secondary Parkinsonism, or dementia in PD. We applied Cox proportional hazard models to investigate the associations between air pollution and PD mortality, adjusting for potential confounders.

Results: Of 271,720 cohort participants, 381 died from PD during 19.7 years of follow-up. In single-pollutant analyses, we observed positive associations between PD mortality and PM2.5 (hazard ratio per 5 µg/m3: 1.25; 95% confidence interval: 1.01-1.55), NO2 (1.13; 0.95-1.34 per 10 µg/m3), and BC (1.12; 0.94-1.34 per 0.5 × 10-5m-1), and a negative association with O3 (0.74; 0.58-0.94 per 10 µg/m3). Associations of PM2.5, NO2, and BC with PD mortality were linear without apparent lower thresholds. In two-pollutant models, associations with PM2.5 remained robust when adjusted for NO2 (1.24; 0.95-1.62) or BC (1.28; 0.96-1.71), whereas associations with NO2 or BC attenuated to null. O3 associations remained negative, but no longer statistically significant in models with PM2.5. We detected suggestive positive associations with the potassium component of PM2.5.

Conclusion: Long-term exposure to PM2.5, at levels well below current EU air pollution limit values, may contribute to PD mortality.
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Petr75
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Re: PM10

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2023 Jan 25
Department of Environmental and Biological Sciences and Technologies (DISTEBA), University of Salento, Institute of Atmospheric Sciences and Climate, Lecce, Italy
Characterisation of the correlations between oxidative potential and in vitro biological effects of PM10 at three sites in the central Mediterranean
https://pubmed.ncbi.nlm.nih.gov/36716558/

Abstract

Atmospheric particulate matter (PM) is one of the major risks for global health. The exact mechanisms of toxicity are still not completely understood leading to contrasting results when different toxicity metrics are compared. In this work, PM10 was collected at three sites for the determination of acellular oxidative potential (OP), intracellular oxidative stress (OSGC), cytotoxicity (MTT assay), and genotoxicity (Comet assay)...
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Re: PM10

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2023 Feb 3
Environmental, Genetic and Nutritional Epidemiology Research Center (CREAGEN), Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
Particulate matter exposure from motorized traffic and risk of conversion from mild cognitive impairment to dementia: An Italian prospective cohort study
https://pubmed.ncbi.nlm.nih.gov/36740156/

...Conclusions: Our findings suggest that exposure to outdoor air pollutants, PM10 in particular, may non-linearly increase conversion from MCI to dementia above a certain ambient air concentration.
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Re: PM10

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2023 Feb 8
Departamento de Ciencias Químico-Biológicas, Escuela de Ciencias, Universidad de las Américas Puebla, Mexico
Particulate matter and ultrafine particles in urban air pollution and their effect on the nervous system
https://pubmed.ncbi.nlm.nih.gov/36752881/


Abstract

According to the World Health Organization, both indoor and urban air pollution are responsible for the deaths of around 3.5 million people annually. During the last few decades, the interest in understanding the composition and health consequences of the complex mixture of polluted air has steadily increased. Today, after decades of detailed research, it is well-recognized that polluted air is a complex mixture containing not only gases (CO, NOx, and SO2) and volatile organic compounds but also suspended particles such as particulate matter (PM). PM comprises particles with sizes in the range of 30 to 2.5 μm (PM30, PM10, and PM2.5) and ultrafine particles (UFPs) (less than 0.1 μm, including nanoparticles). All these constituents have different chemical compositions, origins and health consequences. It has been observed that the concentration of PM and UFPs is high in urban areas with moderate traffic and increases in heavy traffic areas. There is evidence that inhaling PM derived from fossil fuel combustion is associated with a wide variety of harmful effects on human health, which are not solely associated with the respiratory system. There is accumulating evidence that the brains of urban inhabitants contain high concentrations of nanoparticles derived from combustion and there is both epidemiological and experimental evidence that this is correlated with the appearance of neurodegenerative human diseases. Neurological disorders, such as Alzheimer's and Parkinson's disease, multiple sclerosis, and cerebrovascular accidents, are among the main debilitating disorders of our time and their epidemiology can be classified as a public health emergency. Therefore, it is crucial to understand the pathophysiology and molecular mechanisms related to PM exposure, specifically to UFPs, present as pollutants in air, as well as their correlation with the development of neurodegenerative diseases. Furthermore, PM can enhance the transmission of airborne diseases and trigger inflammatory and immune responses, increasing the risk of health complications and mortality. Therefore, understanding the different levels of this issue is important to create and promote preventive actions by both the government and civilians to construct a strategic plan to treat and cope with the current and future epidemic of these types of disorders on a global scale.
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Re: PM10

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2023 Feb 10
The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Global ambient particulate matter pollution and neurodegenerative disorders: a systematic review of literature and meta-analysis
https://pubmed.ncbi.nlm.nih.gov/36763275/

Abstract

Previous studies on particulate matter (PM) exposure and neurodegenerative disorders showed inconsistent results, and few studies systematically examined the long-term effect of PM on neurodegenerative diseases, including all-cause dementia, Alzheimer's disease, Parkinson's disease, vascular dementia, amyotrophic lateral sclerosis, and cognitive function decline. We systematically searched for published studies in PubMed, Embase, Cochrane Library, and Web of Science up to October 31, 2022. To facilitate a comparison of effect sizes from different studies, we standardized units across studies to a 10 μg/m3 increase for PM. Heterogeneity was assessed by Cochran's Q test and I2 statistic. Publication bias was evaluated using funnel plots and Egger's tests. Subgroup analysis, meta-regression, and sensitivity analysis were performed. The protocol for this review was registered with PROSPERO (CRD42021277112). Of the 3403 originally identified studies, a meta-analysis was finally performed in 49 studies. The results showed that there was a significant positive association between long-term PM2.5 exposure and all-cause dementia, Alzheimer's disease as well as Parkinson's disease, with pooled OR of 1.30 (95%CI: 1.14, 1.47, I2 = 99.3%), 1.65 (95%CI: 1.37, 1.94, I2 = 98.2%), and 1.17 (95%CI: 1.00, 1.33, I2 = 91.8%). A positive association between PM10 and vascular dementia was observed (OR = 1.12, 95%CI: 1.04, 1.21, I2 = 0.0%). Association between PM exposure and decreased cognitive function score was found. Our results highlight the important role of PM pollution, particularly PM2.5, in the risk of age-related neurodegenerative diseases and cognitive function decline.
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Re: PM10

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PM

2023 Feb 21
Department of Environmental Medicine, School of Medicine, Graduate Program in System Health Science and Engineering, Ewha Womans University, Seoul, Republic of Korea
Effect of PM concentration on anemia blood indicators reduced by air purifiers
https://pubmed.ncbi.nlm.nih.gov/36822522/

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MS

April 19, 2022
mymsteam.com
How Anemia Can Worsen Multiple Sclerosis Fatigue
https://www.mymsteam.com/resources/how- ... is-fatigue

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Is anemia a probable cause of fatigue in patients with multiple sclerosis? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829269/
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Re: PM10

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PM

2023 Feb 15
Department of Environmental Health Science, Mailman School of Public Health, Columbia University, New York, NY, USA
Air pollution and decreased bone mineral density among Women's Health Initiative participants
https://pubmed.ncbi.nlm.nih.gov/36820096/

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MS

2019 Oct
School of Rehabilitation Therapy (EJB, MLF), Faculty of Health Sciences, Queen's University, Kingston, Ontario
Multiple sclerosis is associated with low bone mineral density and osteoporosis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814427/
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Re: PM10

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2023 Jul
Department of Neurology, Dr BL Kapoor Memorial (BLK-MAX) Hospital, MAX Healthcare Rajendra Place,
All India Institute of Medical Sciences, Delhi, India.
Beware! We are Skating on a Thin Ice: Air Pollution is a Killer
https://pubmed.ncbi.nlm.nih.gov/37449683/


Abstract

Air pollution has rapidly emerged as a major environmental hazard in recent times, with potentially catastrophic ramifications for human health.1,2 It has the ability to severely and adversely impact multiple body systems, including the central nervous system (CNS), cardiovascular, dermatological, respiratory, ophthalmologic, and gastrointestinal health. It is a global public health hazard, being responsible for an estimated 6.7 million deaths worldwide in 2016. The World Health Organization (WHO) estimates that between 3.2 to 4.8 million persons succumb yearly because of outdoor and indoor air pollution, respectively. Nearly 90% of people worldwide live in regions where mean air pollution levels exceed acceptable ranges established by WHO.3 Air pollution is caused by several components in the air, which include particulate matter (PM), organic compounds such as polycyclic aromatic hydrocarbons (PAH), inorganic compounds, gases such as nitrogen oxides (NOx), and sulfur dioxide (SO2). PM, in turn, is further classified based on the aerodynamic diameter of the particles: coarse particles are defined as those with a diameter between 2.5 and 10 µm (PM10), fine particles are those with a diameter <2.5 µm but above 100 nm (PM2.5) and ultrafine particles are those with diameter below 100 nm (ultrafine PM). Larger particles (PM10) are more common in industrial emissions, and smaller particles in automobile emissions. Data continues to accumulate on the adverse consequences of air pollution on brain health, with pathogenetic contributions  to the development of dementia, headache, stroke, demyelinating conditions, and psychiatric disorders.
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Petr75
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Re: PM10

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PM

2023 Jul 13
Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida
Association of air pollution with postmenopausal breast cancer risk in UK Biobank
https://pubmed.ncbi.nlm.nih.gov/37443054/

------------------------------------

MS


Front. Neuroinform., 03 May 2023
Multiple sclerosis and breast cancer risk: a meta-analysis of observational and Mendelian randomization studies
https://www.frontiersin.org/articles/10 ... 54916/full
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Re: PM10

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2023 Aug 7
Infettare, Facultad de Medicina, Universidad Cooperativa de Colombia, Medellín
Particulate matter impairs immune system function by up-regulating inflammatory pathways and decreasing pathogen response gene expression
https://pubmed.ncbi.nlm.nih.gov/37550362/


Abstract

Airborne particulate matter produced by industrial sources and automobiles has been linked to increased susceptibility to infectious diseases and it is known to be recognized by cells of the immune system. The molecular mechanisms and changes in gene expression profiles induced in immune cells by PM have not been fully mapped out or systematically integrated. Here, we use RNA-seq to analyze mRNA profiles of human peripheral blood mononuclear cells after exposure to coarse particulate matter (PM10). Our analyses showed that PM10 was able to reprogram the expression of 1,196 genes in immune cells, including activation of a proinflammatory state with an increase in cytokines and chemokines. Activation of the IL-36 signaling pathway and upregulation of chemokines involved in neutrophil and monocyte recruitment suggest mechanisms for inflammation upon PM exposure, while NK cell-recruiting chemokines are repressed. PM exposure also increases transcription factors associated with inflammatory pathways (e.g., JUN, RELB, NFKB2, etc.) and reduces expression of RNases and pathogen response genes CAMP, DEFAs, AZU1, APOBEC3A and LYZ. Our analysis across gene regulatory and signaling pathways suggests that PM plays a role in the dysregulation of immune cell functions, relevant for antiviral responses and general host defense against pathogens.
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Petr75
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Re: PM10

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Petr75 wrote: Wed Aug 09, 2023 1:49 am 2023 Aug 7
Infettare, Facultad de Medicina, Universidad Cooperativa de Colombia, Medellín
Particulate matter impairs immune system function by up-regulating inflammatory pathways and decreasing pathogen response gene expression
https://pubmed.ncbi.nlm.nih.gov/37550362/


Abstract

Airborne particulate matter produced by industrial sources and automobiles has been linked to increased susceptibility to infectious diseases and it is known to be recognized by cells of the immune system. The molecular mechanisms and changes in gene expression profiles induced in immune cells by PM have not been fully mapped out or systematically integrated. Here, we use RNA-seq to analyze mRNA profiles of human peripheral blood mononuclear cells after exposure to coarse particulate matter (PM10). Our analyses showed that PM10 was able to reprogram the expression of 1,196 genes in immune cells, including activation of a proinflammatory state with an increase in cytokines and chemokines. Activation of the IL-36 signaling pathway and upregulation ....
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MS

2018 Sep 25
Department of Immunology, School of medicine , Isfahan University of Medical Sciences , Isfahan , Iran
Serum level of interleukin 36 in patients with multiple sclerosis
https://pubmed.ncbi.nlm.nih.gov/30252593/

....Conclusion: in this study for the first time, significantly higher serum level of IL36 was determined in RRMS patients comparing healthy individuals. This data may suggest important roles of this cytokine in MS pathogenesis.
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Re: PM10

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2023 Aug 7
Department of Cardiology, Fujian Provincial Hospital, Shengli Clinical Medical College, Fujian Medical University, China
Association of ambient PM10 and PM2.5 with coronary stenosis measured using selective coronary angiography
https://pubmed.ncbi.nlm.nih.gov/37556955/

...Conclusion: Our study provides the first evidence that chronic ambient PM10 and PM2.5 exposure was associated with coronary stenosis assessed by GS in patients with suspected coronary artery disease and reveals its potential mediators.
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Re: PM10

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2023 Aug 7
Plateau Atmosphere and Environment Key Laboratory of Sichuan Province, School of Atmospheric Sciences, Chengdu University of Information Technology, China
Short-term joint effects of ambient PM2.5 and O3 on mortality in Beijing, China
https://pubmed.ncbi.nlm.nih.gov/37608983/

...Results: The results suggested that both PM2.5 and O3 exhibited the greatest individual effects on the three mortality categories with cumulative lag day 01. Increases in the nonaccidental, cardiovascular, and respiratory mortality categories were 0.32%, 0.36%, and 0.43% for PM2.5 (lag day 01) and 0.22%, 0.37%, and 0.25% for O3 (lag day 01), respectively. There were remarkably synergistic interactions between PM2.5 and O3 on the three mortality categories
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Re: PM10

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2023 Aug 4
Department of Neurology, The First Affiliated Hospital of Jinan University, Guangzhou, China
Associations of air pollution with all-cause dementia, Alzheimer's disease, and vascular dementia: a prospective cohort study based on 437,932 participants from the UK biobank
https://pubmed.ncbi.nlm.nih.gov/37600021/
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Re: PM10

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2023 Oct 1
Institute of Child and Adolescent Health, School of Public Health, Peking University, China
Association of Short-Term Co-Exposure to Particulate Matter and Ozone with Mortality Risk
https://pubmed.ncbi.nlm.nih.gov/37779243/

Abstract
A complex regional air pollution problem dominated by particulate matter (PM) and ozone (O3) needs drastic attention since the levels of O3 and PM are not decreasing in many parts of the world. Limited evidence is currently available regarding the association between co-exposure to PM and O3 and mortality. A multicounty time-series study was used to investigate the associations of short-term exposure to PM1, PM2.5, PM10, and O3 with daily mortality from different causes ...
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