Hello

New members should feel free to introduce themselves here
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NHE
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Re: Hello

Post by NHE »

Great! I hope you do well with it. :peace:
Zyklon
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Re: Hello

Post by Zyklon »

Thank you NHE.
Pain! You made me a, you made me a believer, believer
Pain! You break me down, you build me up, believer, believer
Pain! Oh let the bullets fly, oh let them rain
My life, my love, my drive, it came from... Pain!
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NHE
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Re: Hello

Post by NHE »

Did you consider Kesimpta? The self injections might be easier than getting an infusion.

Also, if you’re not taking Na-R-Lipoate then you might want to add it to your regimen. It seems to do fairly well slowing down atrophy.

Here’s a link to news about a small phase 2 study which found that lipoic acid prevented atrophy better than Ocrevus.

https://www.medicalnewstoday.com/articles/318225

Atrophy appears to be a critical factor.

Atrophy prevention Correlates with cognition.
Zyklon
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Location: Turkey

Re: Hello

Post by Zyklon »

I'm done with injections. Five years of Rebif is enough :)

Lipoic acid seems promising. I just want to see some phase 3 studies.
Pain! You made me a, you made me a believer, believer
Pain! You break me down, you build me up, believer, believer
Pain! Oh let the bullets fly, oh let them rain
My life, my love, my drive, it came from... Pain!
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NHE
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Posts: 6211
Joined: Sat Nov 20, 2004 3:00 pm
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Re: Hello

Post by NHE »

Zyklon wrote: Fri Nov 17, 2023 12:27 am I'm done with injections. Five years of Rebif is enough :)
I took Avonex for 10 years. A once a month injection of Kesimpta would be no big deal for me.
Zyklon wrote: Fri Nov 17, 2023 12:27 amLipoic acid seems promising. I just want to see some phase 3 studies.
Dennis Bourdette’s research group at Oregon Health Science University has been studying lipoic acid in MS for roughly 20 years.

Here’s his OHSU profile.

https://www.ohsu.edu/people/dennis-bour ... -fana-faan

Here’s a link to his papers on lipoic acid.

https://pubmed.ncbi.nlm.nih.gov/?term=B ... ate&page=2

A phase 3 study is unlikely. Lipoic acid and Na-R-Lipoate are both available as OTC supplements. As such, there’s little financial resources nor incentive for conducting a large multicenter phase 3 trial.
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