Curcumin nanoparticles in neurological disease

[NHE]

Curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders
Int J Nanomedicine. 2019 Jun 17:14:4449-4460.

Curcumin as a hydrophobic polyphenol is extracted from the rhizome of Curcuma longa. Curcumin is widely used as a dietary spice and a topical medication for the treatment of inflammatory disorders in Asia. This compound also possesses remarkable anti-inflammatory and neuroprotective effects with the ability to pass from the blood brain barrier. Based on several pharmacological activities of curcumin, it has been introduced as an ideal candidate for different neurological disorders. Despite the pleiotropic activities of curcumin, poor solubility, rapid clearance and low stability have limited its clinical application. In recent years, nano-based drug delivery system has effectively improved the aqueous solubility and bioavailability of curcumin. In this review article, the effects of curcumin nanoparticles and their possible mechanism/s of action has been elucidated in various central nervous system (CNS)-related diseases including Parkinson's disease, Huntington disease, Alzheimer's disease, Multiple sclerosis, epilepsy and Amyotrophic Lateral Sclerosis. Furthermore, recent evidences about administration of nano-curcumin in the clinical trial phase have been described in the present review article.

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[DIM]

Curcumin Formulations for Better Bioavailability:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061533/

[NHE]

Curcumin Formulations for Better Bioavailability:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061533/

Thanks for the link to the paper. I hadn't seen that one.

I take Longvida Curcumin.

[DIM]

Curcumin Formulations for Better Bioavailability:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061533/

Thanks for the link to the paper. I hadn't seen that one.

I take Longvida Curcumin.

I was giving it to my wife until last year that I found CurQfen is more bioavailable, while Optima C-PC (Longvida + Phosphatidyl Choline) stopped it's production!
CurQfen has all the natural curcuminoids found in curcumin and if you take it with Turmacin, another bioavailable form of curcumin, you achieve max bioavailability!
This is what I order now: https://www.sunday.de/en/curcumin-ultra ... sules.html


https://www.cambridge.org/core/journals ... 5D45595120