Tropospheric ozone

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O3

January 2010
Toxicological Sciences
Oxidative Stress Caused by Ozone Exposure Induces Loss of Brain Repair in the Hippocampus of Adult Rats

https://academic.oup.com/toxsci/article ... 87/1675262

Abstract

Oxidative stress is involved in many neurodegenerative diseases. Chronic ozone exposure causes a secondary increase of reactive oxygen species, which cause an oxidative stress state in the organism. Ozone is one of the main components of photochemical pollution. Our purpose was to test that oxidative stress caused by chronic low doses of ozone, by itself, alters adult neurogenesis and causes progressive neurodegeneration in the hippocampus, which actions lead to the loss of brain plasticity in the mature central nervous system of rats...

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MS

2024 Jun 7
Section of Neurology, Hospital Universitario del Sureste, Arganda del Rey, Madrid, Spain
Oxidative Stress Markers in Multiple Sclerosis
https://pubmed.ncbi.nlm.nih.gov/38927996/

Data from analyses of central nervous system autopsy material from patients diagnosed with multiple sclerosis, as well as from studies in the main experimental model of multiple sclerosis, experimental autoimmune encephalomyelitis (EAE), suggest the possibility of a role of oxidative stress as well ..

Free full text.

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O3

2017 Jan
Editor’s Highlight: Role of Spleen-Derived Macrophages in Ozone-Induced Lung Inflammation and Injury
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080856/

DISCUSSION
Earlier studies have shown that the spleen is a source of inflammatory monocytes that rapidly accumulate at sites of tissue injury (Bao et al., 2010; Kim et al., 2014; Swirski et al., 2009). Once localized at these sites, they develop into macrophages with cytotoxic and pro-inflammatory activities, contributing to the pathogenesis of acute ischemic brain injury and myocardial infarction (Bao et al., 2010; Swirski et al., 2009)...
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MS

2024 Jul 3
Span of spleen is associated with disability status in multiple sclerosis: a cross-sectional abdominopelvic ultrasonography study
https://pubmed.ncbi.nlm.nih.gov/38961187/

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O3

2023 Mar 1
Department of Pharmacology and Toxicology, The Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA
The bidirectional lung brain-axis of amyloid-β pathology: ozone dysregulates the peri-plaque microenvironment
https://pubmed.ncbi.nlm.nih.gov/35348636/

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MS

2024 Jul 4
Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA
Unexpected Low Rate of Amyloid-β Pathology in Multiple Sclerosis Patients
https://pubmed.ncbi.nlm.nih.gov/38963256/

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O3

2024 Jul 2
Long-term exposure to ozone and sleep disorders in children: A multicity study in China
https://pubmed.ncbi.nlm.nih.gov/38964573/

..Moreover, these associations were heterogeneous regionally, with more prominent associations among children residing in southeast region than in northeast and northwest regions in China. We concluded that long-term exposure to O3 is positively associated with risks of childhood sleep disorders. These associations varied by geographical region of China.

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MS

2015 May 15
Department of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovakia
Sleep Disorders in Patients with Multiple Sclerosis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410929/

Objective:
Poor sleep is a frequent symptom in patients with multiple sclerosis (MS). The objective of the study was to assess the relationship between nocturnal polysomnographic (PSG) findings and quality of sleep, fatigue, and increased daytime sleepiness among patients with MS.

Conclusion:
Presence of RLS seems to be the main factor determining poor sleep, fatigue, and daytime somnolence. Sleep disordered breathing and its severity influences only fatigue in patients with MS.
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1993
The geographic distribution of multiple sclerosis: a review
https://pubmed.ncbi.nlm.nih.gov/8327018/

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2024 Jul
School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia
All-cause, cardiovascular, and respiratory mortality and wildfire-related ozone: a multicountry two-stage time series analysis
https://pubmed.ncbi.nlm.nih.gov/38969473/

Interpretation: In this study, we observed an increase in all-cause and respiratory mortality associated with short-term wildfire-related O3 exposure. Effective risk and smoke management strategies should be implemented to protect the public from the impacts of wildfires.

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O3 and Parkinson's Disease


2015 May
Associations of Ozone and PM2.5 Concentrations With Parkinson's Disease Among Participants in the Agricultural Health Study
https://pubmed.ncbi.nlm.nih.gov/25951420/

Results: We observed positive associations of Parkinson's disease with ozone (odds ratio = 1.39; 95% CI: 0.98 to 1.98) and fine particulate matter (odds ratio = 1.34; 95% CI: 0.93 to 1.93) in North Carolina but not in Iowa.

Conclusions: The plausibility of an effect of ambient concentrations of these pollutants on Parkinson's disease risk is supported by experimental data demonstrating damage to dopaminergic neurons at relevant concentrations. Additional studies are needed to address uncertainties related to confounding and to examine temporal aspects of the associations we observed.

2024 Jul
Association of Autoimmune Diseases with the Risk of Parkinson's Disease
https://pubmed.ncbi.nlm.nih.gov/38981460/

Conclusion: Our study provided evidence from observational analyses that MS was associated with an increased risk of PD. Further investigations should be performed to determine the causal association and potential pathophysiology between MS and PD.

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O3

2024 Jul 10
Climate Air Quality Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia
Short-term ozone exposure and cancer mortality in Brazil: A nationwide case-crossover study
https://pubmed.ncbi.nlm.nih.gov/38985095/

A linear and non-threshold exposure-response relationship was observed for short-term exposure to O3 with cancer mortality, with a 1.00% (95% CI: 0.79%-1.20%) increase in all-cancer mortality risks for each 10-μg/m3 increment of three-day average O3. Kidney cancer was most strongly with O3 exposure, followed by cancers of the prostate, stomach, breast, lymphoma, brain and lung...

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MS

January 26, 2021
neurology.org
Cancer Incidence and Mortality Rates in Multiple Sclerosis
https://www.neurology.org/doi/10.1212/W ... 0000011219

Conclusion
The incidence of breast and colorectal cancers does not differ between persons with and without MS; however, the incidence of bladder cancer is increased. Reported differences in the incidence of some cancers in the MS population may reflect ascertainment differences rather than true differences.
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December 02, 2022
Renal diseases associated with multiple sclerosis: A narrative review
https://journals.lww.com/md-journal/ful ... s_.64.aspx

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O3

April 15, 1981
The Journal of Chemical Physics
Matrix reactions of copper atoms and ozone molecules. Infrared spectrum of CuO
https://ui.adsabs.harvard.edu/abs/1981J ... T/abstract
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MS

2025 Apr 1
Institute of Experimental Neurology, Division of Neuroscience, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milan, Italy
Role of copper in central nervous system physiology and pathology
https://pubmed.ncbi.nlm.nih.gov/38989937/

Abstract

Copper is a transition metal and an essential element for the organism, as alterations in its homeostasis leading to metal accumulation or deficiency have pathological effects in several organs, including the central nervous system. Central copper dysregulations have been evidenced in two genetic disorders characterized by mutations in the copper-ATPases ATP7A and ATP7B, Menkes disease and Wilson's disease, respectively, and also in multifactorial neurological disorders such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis...

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O3

2021 Nov 8
Oxidative Stress Caused by Ozone Exposure Induces Changes in P2X7 Receptors, Neuroinflammation, and Neurodegeneration in the Rat Hippocampus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592727/

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MS

2024 Sep
Increased concentrations of P2X7R in oligodendrocyte derived extracellular vesicles of Multiple sclerosis patients
https://pubmed.ncbi.nlm.nih.gov/38996986/

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2024 Jul 23
School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and National Health Commission (NHC) Key Lab of Health Technology Assessment, IRDR ICoE on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health, Fudan University, Shanghai, China
Joint Effect of Short-Term Exposure to Fine Particulate Matter and Ozone on Mortality: A Time Series Study in 272 Chinese Cities
https://pubmed.ncbi.nlm.nih.gov/38995089/

... Our results found synergistic effects of short-term coexposure to PM2.5 and O3 on mortality and suggested underestimations of attributable risks without considering their synergistic effects.

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O3

November 2022
Ambient ozone pollution and prevalence of chronic kidney disease: A nationwide study based on the China National survey of chronic kidney disease
https://www.sciencedirect.com/science/a ... 3522020963

Highlights

•The first nationwide study to evaluate the association between O3 and CKD in China.
•O3 air pollution was positively associated with odds of CKD prevalence.
•Stronger associations were found in urban regions.
•Stronger associations in young adults and people with high socio-economic status.

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MS

2022 Dec 2
Renal diseases associated with multiple sclerosis: A narrative review
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726425/

..Conclusion

Although kidney disease can be associated with MS, few cases have been reported in the literature. The pathogenesis of renal disease in these patients can be related to lower urinary tract dysfunction, recurrent UTI, and treatment with immunomodulatory agents such as interferons. Therefore, neurologists and other physicians managing patients with MS should be aware of the risk of renal disease and monitor patients’ renal function closely during the course of treatment. Further studies are needed to explore renal diseases and their prevention in patients with MS.
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2024 Jul
Regarding the "Renal dysfunction in AQP4 NMOSD and MS; a potential predictor of relapse and prognosis"
https://pubmed.ncbi.nlm.nih.gov/38763434/

(No abstract available)

2024 Jul 11
Department of Environmental Medicine, College of Medicine, Ewha Womans University, Seoul, Republic of Korea
Air pollution and acute kidney injury with comorbid disease: A nationwide case-crossover study in South Korea
https://pubmed.ncbi.nlm.nih.gov/39002627/

Abstract
Emerging evidence suggests that air pollution is a significant contributor to the global burden of kidney disease...

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2024 Jul 6
Yearly change in air pollution and brain aging among older adults: A community-based study in Taiwan
https://pubmed.ncbi.nlm.nih.gov/39002330/

Results: Overall, all pollutant concentrations, except O3, decreased over the 10-year period.

Conclusions: Greater rate of reduction in air pollution was associated with better attention and attention-related white matter integrity. These results provide insight into the mechanism underlying the relationship between air pollution, brain health, and cognitive aging among older adults.

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08 April 2021
Epidemiology, treatment patterns and healthcare utilizations in multiple sclerosis in Taiwan
https://www.nature.com/articles/s41598-021-86347-3

..These geographical variations in the incidence and prevalence of MS have resulted in an imbalance of “real-world data” of MS to support clinical practice and health policy among different countries. Due to the high incidence and prevalence of MS in North America and Europe, studies regarding the epidemiology and disease burden on MS have been thoroughly conducted and updated during the past few decades1,2,3,4,5,6,7,8,9,10. In contrast, studies focused on MS in Asia were very limited11,12. Nonetheless, some previous studies conducted in Asia still suggested an increasing trend in the prevalence and incidence of MS over the past couple of years13,14,15,16,17,18,19. The underlying cause of the increase remains obscure and is thought to be beyond the mere evolution of diagnostic criteria13. These findings highlight the need for more studies on MS, particularly in Asia.

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O3

2024 Jul 14
Dept. of Neuroscience and Rehabilitation, University of Ferrara, Italy
Tropospheric ozone effect on olfactory perception and olfactory bulb dopaminergic interneuron excitability
https://pubmed.ncbi.nlm.nih.gov/39004287/

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MS

2022 Apr 19
Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Olfactory dysfunction in patients with multiple sclerosis; A systematic review and meta-analysis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017946/