CCSVI MS DEMOTED TO A CO MORBITITY

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.
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vesta
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CCSVI MS DEMOTED TO A CO MORBITITY

Post by vesta »

Check out the Gavin Giovannoni Video The Future of MS Therapy Vidéos de gavin giovannoni future of MS therapy after 48 minutes when he speaks of Vascular Comorbitity which can cause a disability gap of 6 years - enormous. It would seem perfectly legitimate to see if one has a vascular problem and treat if possible. This should help deal with the MS lobby-s resistance to see value in the CCSVI question. Prof Giovannoni mentions the arteries when he must know of the considerable work addressing venous anomolies. I am absolutely certain during an attack stress causes my veins to malfunction sending blood? into the CNS.. I am wary of venoplasty, prefer continuing with manual release of spasms in the vascular system. While maybe one third have enjoyed major relief through venoplasty, maybe a third minor improvement, one third none at all. There is always the danger of blood clots closing of the veins/ I don't want to risk being worse off after than before. I know one lady who was in heaven after venoplasty, but when she was obliged to cease blood thinner for another surgery, a blood clot closed off a jugular. I have not adequtely treated my self for the EBV. I keep in mind that the EBV re-activates in a low oxygen environment so keeping proper blood flow is essential to prevent EBV emergence. But I may take an anti viral when my spirits are low. Anyway, to head off scepticism about CCSVI I will emphasize VASCULAR CO MORBITITY which may be more prevalent than Dr Giovannoni thinks. Chinese researchers (and Dr Zamboni) have found blood flow problems in MS. I am convinced the more serious damage to CNS for me occurs during an "attack' of blood back jets, that the damage caused by "smoldering MS" is minimal by comparison.

Best regards, Vesta

The Future of Multiple Sclerosis Therapy
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The Future of Multiple Sclerosis Therapy
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Leonard
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Re: CCSVI MS DEMOTED TO A CO MORBITITY

Post by Leonard »

Hi Vesta,

CCSVI weakens or breaks the BBB.
Herpes viridae may creep into the CNS from the nasopharynx via the Virchow Robin space.

It is not the stress factor that during an attack causes malfunction because of poor bloodflow.
It is the herpes viridae that cause the mitochondria to stop producing ATP.
Besides the powerhouse of the cell, the mitochondria are the cellular controller.
The synapse then lacks the energy to pass nervous signals.

This triggers the production of interferons in the cell.
Interferon stimulated genes encode proteins that inhibit various stages of the viral life cycle e.g. they inhibit viral protein synthesis, degrade viral RNA, block replication by interfering with the assembly of viral particles.

Indeed, as you say, EBV may reactivate in a low oxygen environment and cause a lot of trouble.
The electron transport chains of the mitochondria may break, one by one.
This will result in excessive production by the mitochondria of superoxide.
Reacting with NO from iNOS, heavy oxidants will kill the cell after which it will be removed unless..

And indeed, restoring the bloodflow may help you to strengthen the immunity for herpes.
As will Vitamin D.
And antivirals, perhaps even Metformin as that lowers the ROS production of Complex I.

Giovannoni is certainly one of the more open minds when it comes to MS.
But I think he is also still entangled in old medical thinking and has difficulty letting go of the old ideas.

Best regards, Leo
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DIM
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Re: CCSVI MS DEMOTED TO A CO MORBITITY

Post by DIM »

If that's the case could a strong antiviral stop MS progression by stopping Herpesviridae reactivation?
For example Dipyridamole, a medicine for cardiovascular disease, among others prevents EBV reactivation and potentiates the activity of various Acyclic Nucleoside Phosphonates against Varicella-Zoster Virus, Herpes Simplex Virus and Human Cytomegalovirus:

https://scholar.google.gr/scholar?q=dip ... i=scholart
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Leonard
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Re: CCSVI MS DEMOTED TO A CO MORBITITY

Post by Leonard »

Anti virals work to prevent one gets MS. HIV patients who are on a HAART (highly active anti retroviral therapy) won't get MS. There is enough epidemiological evidence for that.

To what extent you can stop MS progression by dampening herpes reactivation once the T/B cell hyperimmunization has been switched on is less clear to me. I seem to remember that by anti virals like acyclovir you may halve the concentration of EBV infected B cells in 11 months time. And I guess then progression will slow down.
vesta
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Re: CCSVI MS DEMOTED TO A CO MORBITITY

Post by vesta »

Greetings:
Leonard, how do you treat yourself? (Youmay have said numerous times, direct me if you can.) Thanks Vesta
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Leonard
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Re: CCSVI MS DEMOTED TO A CO MORBITITY

Post by Leonard »

Hi Vesta, thanks for the question. You have got me thinking. I don't do quite enough, actually what I do is very minimal. Leave the question with me for a while. I will get back to you. Regards, Leo
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