Progway 10/2024 (Tecfidera, Ampyra, Nebivolol and strength training)
Tropospheric ozone
Re: Tropospheric ozone
Progway 10/2024 (Tecfidera, Ampyra, Nebivolol and strength training)
Last edited by Petr75 on Sat Jan 04, 2025 12:49 pm, edited 2 times in total.
https://www.eboro.cz
Re: Tropospheric ozone
O3
2024 Dec 3
The role of telomere shortening in ambient ozone exposure-related insulin resistance
https://pubmed.ncbi.nlm.nih.gov/39642730/
Conclusions: Impaired telomere homeostasis may be involved in O3 exposure-related IR via inhibition of glycogen synthesis and acceleration of gluconeogenesis and the specific mechanisms are still further elucidated.
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MS
April 28, 2023
Telomere Length as a biomarker in Multiple Sclerosis
https://www.neurology.org/doi/10.1212/W ... 0000203336
2024 Dec 3
The role of telomere shortening in ambient ozone exposure-related insulin resistance
https://pubmed.ncbi.nlm.nih.gov/39642730/
Conclusions: Impaired telomere homeostasis may be involved in O3 exposure-related IR via inhibition of glycogen synthesis and acceleration of gluconeogenesis and the specific mechanisms are still further elucidated.
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MS
April 28, 2023
Telomere Length as a biomarker in Multiple Sclerosis
https://www.neurology.org/doi/10.1212/W ... 0000203336
https://www.eboro.cz
Re: Tropospheric ozone
2024 Dec 11Petr75 wrote: ↑Fri Feb 16, 2024 5:19 amPetr75 wrote: ↑Fri Jan 06, 2023 10:42 am 2023 Jan 1
Department of Environmental and Biological Sciences, University of Eastern Finland, Kuopio, Finland
Effect of ozone exposure on the foraging behaviour of Bombus terrestris
https://pubmed.ncbi.nlm.nih.gov/36334775/
2024 Feb 12
CEFE, Université de Montpellier, CNRS, EPHE, France
Ozone alters the chemical signal required for plant - insect pollination: The case of the Mediterranean fig tree and its specific pollinator
https://pubmed.ncbi.nlm.nih.gov/38354792/
Tropospheric ozone (O3) is likely to affect the chemical signal emitted by flowers to attract their pollinators through its effects on the emission of volatile organic compounds (VOCs) and its high reactivity with these compounds in the atmosphere....
School of Agriculture, Policy and Development, University of Reading, Whiteknights, Reading, Berkshire RG6 6EU, UK
Diesel exhaust and ozone adversely affect pollinators and parasitoids within flying insect communities
https://pubmed.ncbi.nlm.nih.gov/39667156/
https://www.eboro.cz
Re: Tropospheric ozone
O3
2024 Dec 24
Evidence of sex differences in ozone-induced oxysterol and cytokine levels in differentiated human nasal epithelial cells
https://pubmed.ncbi.nlm.nih.gov/39716873/
...We and others have previously demonstrated that O3 oxidizes lipids, particularly cholesterol, into electrophilic oxysterols, such as secosterol B (SecoB), which can adduct proteins, thus altering cellular signaling pathways
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MS
2019 May 13
Oxysterols and apolipoproteins in multiple sclerosis: a 5 year follow-up study
https://pmc.ncbi.nlm.nih.gov/articles/PMC6602132/
... Oxysterol and apolipoprotein changes were associated with conversion to SP-MS.
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2017 Oct 13
Cytokine Signalingin Multiple Sclerosis and Its Therapeutic Applications
... Clinical studies have shown that progression of MS correlates with the abnormal expression of certain cytokines.
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2024 Dec 24
"A patent review on arachidonic acid lipoxygenase (LOX) inhibitors for the treatment of neurodegenerative diseases (2018-present)"
https://pubmed.ncbi.nlm.nih.gov/39717968/
2024 Dec 24
Evidence of sex differences in ozone-induced oxysterol and cytokine levels in differentiated human nasal epithelial cells
https://pubmed.ncbi.nlm.nih.gov/39716873/
...We and others have previously demonstrated that O3 oxidizes lipids, particularly cholesterol, into electrophilic oxysterols, such as secosterol B (SecoB), which can adduct proteins, thus altering cellular signaling pathways
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MS
2019 May 13
Oxysterols and apolipoproteins in multiple sclerosis: a 5 year follow-up study
https://pmc.ncbi.nlm.nih.gov/articles/PMC6602132/
... Oxysterol and apolipoprotein changes were associated with conversion to SP-MS.
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2017 Oct 13
Cytokine Signalingin Multiple Sclerosis and Its Therapeutic Applications
... Clinical studies have shown that progression of MS correlates with the abnormal expression of certain cytokines.
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2024 Dec 24
"A patent review on arachidonic acid lipoxygenase (LOX) inhibitors for the treatment of neurodegenerative diseases (2018-present)"
https://pubmed.ncbi.nlm.nih.gov/39717968/
https://www.eboro.cz
Re: Tropospheric ozone
2024 Dec 23Petr75 wrote: ↑Wed Jun 19, 2024 12:12 pm O3
November 2019
sciencedirect.com
Weather, ambient air pollution, and risk of migraine headache onset among patients with migraine
https://www.sciencedirect.com/science/a ... 2019300662
Results
The mean age was 35 years and 88% were women. Mean temperature was 56.9 °F, relative humidity 67.3%, and fine particulate matter 7.3 μg/m3. Higher relative humidity was associated with higher odds of migraine headache, but the association was only observed in warm season (April–September). Higher levels of daily maximum 8-hour ozone and daily maximum 8-hour carbon monoxide appeared to be associated with higher odds of migraine headache onset in cold season (October–March).
Migraine in the multiple sclerosis prodrome: a prospective nationwide cohort study in pregnant women
https://pubmed.ncbi.nlm.nih.gov/39710642/
..Conclusions: Women with MS have increased risk of migraine, but not other headaches, up to a decade before the onset of classical MS symptoms. This supports that migraine can be a symptom of the MS prodrome. Special attention in people with migraine may lead to earlier recognition of MS.
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Re: Tropospheric ozone
O3
1 February 2023
Impact of ground-level ozone exposure on sleep quality and electroencephalogram patterns at different time scales
https://www.sciencedirect.com/science/a ... 5122023520
..• Effect of ozone on sleep quality accumulated at different time scales, with greater effect at longer time course.
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MS
2024 Nov 21
Can Multiple Sclerosis-Related Symptoms Determine Sleep Disorders?
https://pubmed.ncbi.nlm.nih.gov/39621806/
BACKGROUND: Sleep disorders are common and various in persons with multiple sclerosis (PwMS). However, their assessment and management remain in the background compared with motor symptoms ....
1 February 2023
Impact of ground-level ozone exposure on sleep quality and electroencephalogram patterns at different time scales
https://www.sciencedirect.com/science/a ... 5122023520
..• Effect of ozone on sleep quality accumulated at different time scales, with greater effect at longer time course.
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MS
2024 Nov 21
Can Multiple Sclerosis-Related Symptoms Determine Sleep Disorders?
https://pubmed.ncbi.nlm.nih.gov/39621806/
BACKGROUND: Sleep disorders are common and various in persons with multiple sclerosis (PwMS). However, their assessment and management remain in the background compared with motor symptoms ....
https://www.eboro.cz
Re: Tropospheric ozone
2024 Dec 30
Associations between short-term exposure to air pollution and acute exacerbation of chronic bronchitis: A time-stratified case-crossover study
https://pubmed.ncbi.nlm.nih.gov/39743149/
Conclusions: This study demonstrates that short-term exposure to air pollution was significantly associated with higher risk of AECB. O3 might contribute the most to AECB. Policymakers should pay more attention to air pollution control.
Associations between short-term exposure to air pollution and acute exacerbation of chronic bronchitis: A time-stratified case-crossover study
https://pubmed.ncbi.nlm.nih.gov/39743149/
Conclusions: This study demonstrates that short-term exposure to air pollution was significantly associated with higher risk of AECB. O3 might contribute the most to AECB. Policymakers should pay more attention to air pollution control.
https://www.eboro.cz
Re: Tropospheric ozone
2024 Dec 30
Airway microbiota dysbiosis and metabolic disorder in ozone and PM2.5 co-exposure induced lung inflammatory injury in mice
https://pubmed.ncbi.nlm.nih.gov/39740428/
Co-exposure to ground-level ozone (O3) and fine particles (PM2.5, ≤ 2.5 µm in diameter) has become a primary scenario for air pollution exposure of urbanites in China...
Airway microbiota dysbiosis and metabolic disorder in ozone and PM2.5 co-exposure induced lung inflammatory injury in mice
https://pubmed.ncbi.nlm.nih.gov/39740428/
Co-exposure to ground-level ozone (O3) and fine particles (PM2.5, ≤ 2.5 µm in diameter) has become a primary scenario for air pollution exposure of urbanites in China...
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Re: Tropospheric ozone
O3
2025 Jan 2
Estimating the Risk of Women Anemia Associated with Ozone Exposure Across 123 Low- and Middle-Income Countries: A Multicenter Epidemiological Study
https://pubmed.ncbi.nlm.nih.gov/39745190/
..In the fully adjusted regression model, each 10 ppb increase in annual O3 concentration was associated with an 8% elevation in anemia risk.
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MS
April 19, 2022
mymsteam.com
How Anemia Can Worsen Multiple Sclerosis Fatigue
https://www.mymsteam.com/resources/how- ... is-fatigue
... The relationship between MS and anemia is unclear. However, anemia is approximately twice as likely in people with MS than it is in the general population. The connection seems to work both ways — people with anemia are more than twice as likely to eventually develop MS.
2025 Jan 2
Estimating the Risk of Women Anemia Associated with Ozone Exposure Across 123 Low- and Middle-Income Countries: A Multicenter Epidemiological Study
https://pubmed.ncbi.nlm.nih.gov/39745190/
..In the fully adjusted regression model, each 10 ppb increase in annual O3 concentration was associated with an 8% elevation in anemia risk.
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MS
April 19, 2022
mymsteam.com
How Anemia Can Worsen Multiple Sclerosis Fatigue
https://www.mymsteam.com/resources/how- ... is-fatigue
... The relationship between MS and anemia is unclear. However, anemia is approximately twice as likely in people with MS than it is in the general population. The connection seems to work both ways — people with anemia are more than twice as likely to eventually develop MS.
https://www.eboro.cz
Re: Tropospheric ozone
O3
2013 Oct
Ozone is associated with an increased risk of respiratory exacerbations in patients with cystic fibrosis (CF)
https://pubmed.ncbi.nlm.nih.gov/23493973/
.. Results: In total, 103 patients with CF (median age, 8.9 years) made 408 visits, with a mean ± SD of 4 ± 1.74 visits per patient (range, 2-9). A respiratory disease exacerbation was diagnosed on 142 visits (38.4%). An interquartile range increase in the O3 concentration (45.62 μg/m3) had a positive, delayed (2 days after exposure) effect on the risk of a respiratory exacerbation (relative risk = 1.86; 95% CI, 1.14-3.02).
Conclusions: This study demonstrates that exposure to short-term air pollution in a large urban center increases the risk of a pulmonary exacerbation in patients with CF.
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MS
2005 Oct
Cystic fibrosis and uveitis in childhood and multiple sclerosis at adulthood
https://pubmed.ncbi.nlm.nih.gov/16249765/
Abstract
We report the case of a patient with cystic fibrosis who suffered severe bilateral uveitis, with hypopyon, retinal vasculitis, and polyarthritis when he was 6 years old. No etiology could be found. Multiple sclerosis began when he was 22 years old. This panuveitis was clinically very different from the uveitis usually associated with multiple sclerosis. Polyarthritis and skin vasculitis have been reported in the course of cystic fibrosis, but no uveitis nor retinal vasculitis have been described. This raises the question of the role of multiple sclerosis and cystic fibrosis in the pathogenesis of this case of uveitis.
2013 Oct
Ozone is associated with an increased risk of respiratory exacerbations in patients with cystic fibrosis (CF)
https://pubmed.ncbi.nlm.nih.gov/23493973/
.. Results: In total, 103 patients with CF (median age, 8.9 years) made 408 visits, with a mean ± SD of 4 ± 1.74 visits per patient (range, 2-9). A respiratory disease exacerbation was diagnosed on 142 visits (38.4%). An interquartile range increase in the O3 concentration (45.62 μg/m3) had a positive, delayed (2 days after exposure) effect on the risk of a respiratory exacerbation (relative risk = 1.86; 95% CI, 1.14-3.02).
Conclusions: This study demonstrates that exposure to short-term air pollution in a large urban center increases the risk of a pulmonary exacerbation in patients with CF.
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MS
2005 Oct
Cystic fibrosis and uveitis in childhood and multiple sclerosis at adulthood
https://pubmed.ncbi.nlm.nih.gov/16249765/
Abstract
We report the case of a patient with cystic fibrosis who suffered severe bilateral uveitis, with hypopyon, retinal vasculitis, and polyarthritis when he was 6 years old. No etiology could be found. Multiple sclerosis began when he was 22 years old. This panuveitis was clinically very different from the uveitis usually associated with multiple sclerosis. Polyarthritis and skin vasculitis have been reported in the course of cystic fibrosis, but no uveitis nor retinal vasculitis have been described. This raises the question of the role of multiple sclerosis and cystic fibrosis in the pathogenesis of this case of uveitis.
https://www.eboro.cz
Re: Tropospheric ozone
O3
2021 Nov 26
Effects of Ozone on Hippocampus BDNFand Fos Expressions in Rats with Chronic Compression of Dorsal Root Ganglia
Abstract
The effects of ozone on hippocampal expression levels of brain-derived neurotrophic factor (BDNF) and c-fos protein (Fos) were evaluated in rats with chronic compression of dorsal root ganglia (CCD)
3.6. Gray Values of BDNF and Fos Are Significantly Elevated in Hippocampal Cells after Ozone Intervention
Analysis of the BDNF gray values revealed that although the BDNF level in the CCD + BO3 group (0.76 ± 0.18) was lower than that in the sham group (1.01 ± 0.25) (P = 0.021), it was higher than that in the CCD + AO3 group (0.52 ± 0.14) (P = 0.026), which in turn was higher than that in the CCD group (0.29 ± 0.07) (P < 0.001). Analysis of Fos gray values revealed that the expression of CCD group (1.19 ± 0.23) was higher than that of the sham group (0.42 ± 0.11) (P < 0.001), with downregulated levels in the CCD + AO3 (0.96 ± 0.10) and CCD + BO3 group (0.70 ± 0.19) (P < 0.05).
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MS
2025 Leden 15
BDNF levels in serum and CSF are associated with clinicoradiological characteristics of aggressive disease in MS patients
https://pmc.ncbi.nlm.nih.gov/articles/PMC11735549/
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June 1991
Fos RNA accumulation in multiple sclerosis white matter tissue
https://www.sciencedirect.com/science/a ... 0X91901665
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PQQ increases BDNF, Improves Alzheimer's assessment score
viewtopic.php?p=264256&hilit=BDNF+levels#p264256
2021 Nov 26
Effects of Ozone on Hippocampus BDNFand Fos Expressions in Rats with Chronic Compression of Dorsal Root Ganglia
Abstract
The effects of ozone on hippocampal expression levels of brain-derived neurotrophic factor (BDNF) and c-fos protein (Fos) were evaluated in rats with chronic compression of dorsal root ganglia (CCD)
3.6. Gray Values of BDNF and Fos Are Significantly Elevated in Hippocampal Cells after Ozone Intervention
Analysis of the BDNF gray values revealed that although the BDNF level in the CCD + BO3 group (0.76 ± 0.18) was lower than that in the sham group (1.01 ± 0.25) (P = 0.021), it was higher than that in the CCD + AO3 group (0.52 ± 0.14) (P = 0.026), which in turn was higher than that in the CCD group (0.29 ± 0.07) (P < 0.001). Analysis of Fos gray values revealed that the expression of CCD group (1.19 ± 0.23) was higher than that of the sham group (0.42 ± 0.11) (P < 0.001), with downregulated levels in the CCD + AO3 (0.96 ± 0.10) and CCD + BO3 group (0.70 ± 0.19) (P < 0.05).
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MS
2025 Leden 15
BDNF levels in serum and CSF are associated with clinicoradiological characteristics of aggressive disease in MS patients
https://pmc.ncbi.nlm.nih.gov/articles/PMC11735549/
--------------
June 1991
Fos RNA accumulation in multiple sclerosis white matter tissue
https://www.sciencedirect.com/science/a ... 0X91901665
-------------------------------------------------
------------------------------------------
PQQ increases BDNF, Improves Alzheimer's assessment score
viewtopic.php?p=264256&hilit=BDNF+levels#p264256
https://www.eboro.cz
Re: Tropospheric ozone
2025 Jan 17.Petr75 wrote: ↑Sun Jun 09, 2024 5:42 am O3
8 Feb 2005
ahajournals.org
Ozone Air Pollution Is Associated With Acute Myocardial Infarction
https://www.ahajournals.org/doi/10.1161 ... 6.32135.6e
Conclusions— Observational data confirm that short-term O3 exposure within a period of 1 to 2 days is related to acute coronary events in middle-aged adults without heart disease, whereas NO2 and SO2 are not.
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neurodegenerative diseases
2024 Jun 7
Department of Geriatric Cardiology, General Hospital of Southern Theater Command, Guangzhou, China
Causal effects for neurodegenerative diseases on the risk of myocardial infarction: a two-sample Mendelian randomization study
https://pubmed.ncbi.nlm.nih.gov/38850523/
.. Abstract
Several studies have demonstrated a correlation between neurodegenerative diseases (NDDs) and myocardial infarction (MI), ..
Associations of Ozone Exposure with Serum Biomarkers in Acute Myocardial Infarction Patients in Taiyuan, China: The Mediating Role of Metabolitesn 17
https://pubmed.ncbi.nlm.nih.gov/39839248/
Abstract
Abundant epidemiological studies have conclusively demonstrated the effects of short-term ozone (O3) exposure on the incidence and mortality of cardiovascular diseases...
https://www.eboro.cz
Re: Tropospheric ozone
2025 Jan 17.Petr75 wrote: ↑Mon Jul 22, 2024 9:02 pm O3
January 2010
Toxicological Sciences
Oxidative Stress Caused by Ozone Exposure Induces Loss of Brain Repair in the Hippocampus of Adult Rats
https://academic.oup.com/toxsci/article ... 87/1675262
Abstract
Oxidative stress is involved in many neurodegenerative diseases. Chronic ozone exposure causes a secondary increase of reactive oxygen species, which cause an oxidative stress state in the organism. Ozone is one of the main components of photochemical pollution. Our purpose was to test that oxidative stress caused by chronic low doses of ozone, by itself, alters adult neurogenesis and causes progressive neurodegeneration in the hippocampus, which actions lead to the loss of brain plasticity in the mature central nervous system of rats...
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MS
2024 Jun 7
Section of Neurology, Hospital Universitario del Sureste, Arganda del Rey, Madrid, Spain
Oxidative Stress Markers in Multiple Sclerosis
https://pubmed.ncbi.nlm.nih.gov/38927996/
Data from analyses of central nervous system autopsy material from patients diagnosed with multiple sclerosis, as well as from studies in the main experimental model of multiple sclerosis, experimental autoimmune encephalomyelitis (EAE), suggest the possibility of a role of oxidative stress as well ..
Free full text.
Multiphase Radical Chemical Processes Induced by Air Pollutants and the Associated Health Effects
https://pubmed.ncbi.nlm.nih.gov/39839244/
Abstract
Air pollution is increasingly recognized as a significant health risk, yet our understanding of its underlying chemical and physiological mechanisms remains incomplete. Fine particulate matter (PM2.5) and ozone (O3) interact with biomolecules in intracellular and microenvironments, such as the epithelial lining fluid (ELF), leading to the generation of reactive oxygen species (ROS). These ROS trigger cellular inflammatory responses and oxidative stress, contributing to a spectrum of diseases affecting the respiratory, cardiovascular, and central nervous systems. Extensive epidemiological and toxicological research highlights the pivotal role of ROS in air pollution-related diseases. It is crucial to comprehend the intricate chemical processes and accompanying physiological effects of ROS from air pollutants...
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