O3
2025 Jan 16
Associations of Short-Term Ozone Exposure With Hypoxia and Arterial Stiffness
https://pubmed.ncbi.nlm.nih.gov/39846938/
Conclusions: O3 exposure may reduce oxygen availability, prompting compensatory increases in red blood cells and hemoglobin, which exacerbate arterial stiffening. These findings provide new insights into the mechanisms underlying O3-induced cardiovascular injury.
--------------------------------
MS
2018 Jul 27
Multiple sclerosis disease progression: Contributions from a hypoxia–inflammation cycle
https://pmc.ncbi.nlm.nih.gov/articles/PMC6826859/
... Hypoxia has been associated with multiple sclerosis (MS) for years.1 Type III lesions in MS brain are histologically similar to hypoxic/ischemic lesions, and lesions tend to form in areas that are more susceptible to hypoxia
----------------
January 3, 2025
Meta-Analysis: Vascular Function Worse in People With MS
https://www.ajmc.com/view/meta-analysis ... le-with-ms
..A significant difference in arterial stiffness was found (SMD 0.78; 95% CI, 0.21, 1.36; P = .008), but there were no significant differences in arterial structure or function outcomes, the investigators noted. “These findings may suggest pathophysiological changes in MS may particularly impact arterial stiffness more than other aspects of vascular health,” they wrote.
Tropospheric ozone
Re: Tropospheric ozone
https://www.eboro.cz
Re: Tropospheric ozone
O3
22 February 1996
Chronic inhalation exposure to ozone and nitric acid elevates stress-inducible heat shock protein 70 in the rat lung
https://www.sciencedirect.com/science/a ... 3X9503250J
Abstract
The ability of urban oxidant and acid air pollutants to induce heat shock proteins (HSPs) in the mammalian lung is not known. Such proteins are known to be correlated with environmental stress and pathophysiological conditions...
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MS
2024 Dec 25
Heat shock protein 70 gene polymorphisms in Iranian patients with Multiple sclerosis
https://pubmed.ncbi.nlm.nih.gov/39839348/
Abstract
Genetic factors are effective reagents in susceptibility to multiple sclerosis (MS). Previous studies have shown the relationship between heat shock protein (HSP) gene polymorphisms...
22 February 1996
Chronic inhalation exposure to ozone and nitric acid elevates stress-inducible heat shock protein 70 in the rat lung
https://www.sciencedirect.com/science/a ... 3X9503250J
Abstract
The ability of urban oxidant and acid air pollutants to induce heat shock proteins (HSPs) in the mammalian lung is not known. Such proteins are known to be correlated with environmental stress and pathophysiological conditions...
-----------------------------------------------------
MS
2024 Dec 25
Heat shock protein 70 gene polymorphisms in Iranian patients with Multiple sclerosis
https://pubmed.ncbi.nlm.nih.gov/39839348/
Abstract
Genetic factors are effective reagents in susceptibility to multiple sclerosis (MS). Previous studies have shown the relationship between heat shock protein (HSP) gene polymorphisms...
https://www.eboro.cz
Re: Tropospheric ozone
O3
June 2020
Ozone increases plasma kynurenine-tryptophan ratio and impacts hippocampal serotonin receptor and neurotrophic factor expression: Role of stress hormones
https://www.sciencedirect.com/science/a ... 5120303765
• Ozone inhalation increased the plasma kynurenine/tryptophan ratio.
-----------------------------
MS
2025 Mar
Dysregulation of the Kynurenine Pathway in Relapsing Remitting Multiple Sclerosis and Its Correlations With Progressive Neurodegeneration
https://pubmed.ncbi.nlm.nih.gov/39823555/
Discussion: These findings highlight changes in the biosynthesis of KP during the progression of RRMS and its correlation with axonal loss. This study underscores the potential of targeting the KP in developing novel treatments for neuroaxonal damage in MS and warrants future research in greater depth.
June 2020
Ozone increases plasma kynurenine-tryptophan ratio and impacts hippocampal serotonin receptor and neurotrophic factor expression: Role of stress hormones
https://www.sciencedirect.com/science/a ... 5120303765
• Ozone inhalation increased the plasma kynurenine/tryptophan ratio.
-----------------------------
MS
2025 Mar
Dysregulation of the Kynurenine Pathway in Relapsing Remitting Multiple Sclerosis and Its Correlations With Progressive Neurodegeneration
https://pubmed.ncbi.nlm.nih.gov/39823555/
Discussion: These findings highlight changes in the biosynthesis of KP during the progression of RRMS and its correlation with axonal loss. This study underscores the potential of targeting the KP in developing novel treatments for neuroaxonal damage in MS and warrants future research in greater depth.
https://www.eboro.cz
Re: Tropospheric ozone
O3
2025 Jan 18
Metabolomic profiling reveals systemic metabolic disruptions induced by combined exposure to particulate matter and ozone
https://pubmed.ncbi.nlm.nih.gov/39911777/
Abstract
Air pollution exposure, especially particulate matter (PM) and ozone (O3), poses significant health risks, but the systemic metabolic consequences of combined exposures to PM and O3, remain poorly understood. This study investigated systemic metabolic changes in male spontaneously hypertensive (SH) rats following inhalation exposure to concentrated ambient particles (CAPs) (PM2.5, 150 μg/m3), ozone (O3) (0.2 ppm), and their combination. Rats were exposed for 4 h, and serum samples were collected 1-hour post-exposure. Using targeted metabolomics, we identified significant alterations in metabolites involved in lipid metabolism (phosphatidylcholines), energy metabolism (acylcarnitine C3), and oxidative stress (glutamine). Notably, the combination exposure induced distinct metabolic changes, including increased acylcarnitine C3 levels, suggesting heightened mitochondrial dysfunction. Principal component analysis revealed overlapping profiles between CAPs and controls, indicating a subtler impact of CAPs compared to ozone or combined exposure. These systemic metabolic alterations are aligned with our previously published proteomics findings in cardiac tissues from the same rats, which showed elevated inflammatory markers (e.g., IL-6, TNF-α) and mitochondrial dysfunction. In conclusion, this study provides new insights into the systemic metabolic effects of air pollutant exposure, identifies novel metabolic targets of pollutant-induced toxicity, highlights the complex interactions resulting from combined exposure to multiple pollutants, and underscores the importance of assessing the combined effects of multiple pollutants in air pollution risk assessments.
-----------------------------------------------
MS
Targeting metabolism to treat multiple sclerosis https://pmc.ncbi.nlm.nih.gov/articles/PMC7996022/
..........
Mitochondrial Dysfunction and Multiple Sclerosis https://pmc.ncbi.nlm.nih.gov/articles/PMC6627385/
--------
Changes in Amino Acid and Acylcarnitine Plasma Profiles for Distinguishing Patients with Multiple Sclerosis from Healthy Controls https://onlinelibrary.wiley.com/doi/10. ... 20/9010937
2025 Jan 18
Metabolomic profiling reveals systemic metabolic disruptions induced by combined exposure to particulate matter and ozone
https://pubmed.ncbi.nlm.nih.gov/39911777/
Abstract
Air pollution exposure, especially particulate matter (PM) and ozone (O3), poses significant health risks, but the systemic metabolic consequences of combined exposures to PM and O3, remain poorly understood. This study investigated systemic metabolic changes in male spontaneously hypertensive (SH) rats following inhalation exposure to concentrated ambient particles (CAPs) (PM2.5, 150 μg/m3), ozone (O3) (0.2 ppm), and their combination. Rats were exposed for 4 h, and serum samples were collected 1-hour post-exposure. Using targeted metabolomics, we identified significant alterations in metabolites involved in lipid metabolism (phosphatidylcholines), energy metabolism (acylcarnitine C3), and oxidative stress (glutamine). Notably, the combination exposure induced distinct metabolic changes, including increased acylcarnitine C3 levels, suggesting heightened mitochondrial dysfunction. Principal component analysis revealed overlapping profiles between CAPs and controls, indicating a subtler impact of CAPs compared to ozone or combined exposure. These systemic metabolic alterations are aligned with our previously published proteomics findings in cardiac tissues from the same rats, which showed elevated inflammatory markers (e.g., IL-6, TNF-α) and mitochondrial dysfunction. In conclusion, this study provides new insights into the systemic metabolic effects of air pollutant exposure, identifies novel metabolic targets of pollutant-induced toxicity, highlights the complex interactions resulting from combined exposure to multiple pollutants, and underscores the importance of assessing the combined effects of multiple pollutants in air pollution risk assessments.
-----------------------------------------------
MS
Targeting metabolism to treat multiple sclerosis https://pmc.ncbi.nlm.nih.gov/articles/PMC7996022/
..........
Mitochondrial Dysfunction and Multiple Sclerosis https://pmc.ncbi.nlm.nih.gov/articles/PMC6627385/
--------
Changes in Amino Acid and Acylcarnitine Plasma Profiles for Distinguishing Patients with Multiple Sclerosis from Healthy Controls https://onlinelibrary.wiley.com/doi/10. ... 20/9010937
https://www.eboro.cz
Re: Tropospheric ozone
2025 Feb 4
dilp2-Mediated Insulin Signaling Pathway Was Involved in O3-Induced Multigenerational Effects of Shortened Lifespan in Drosophila melanogasters
https://pubmed.ncbi.nlm.nih.gov/39903660/
..Transcriptome analysis unveiled significant disruptions in metabolic pathways, notably the insulin signaling pathway..
dilp2-Mediated Insulin Signaling Pathway Was Involved in O3-Induced Multigenerational Effects of Shortened Lifespan in Drosophila melanogasters
https://pubmed.ncbi.nlm.nih.gov/39903660/
..Transcriptome analysis unveiled significant disruptions in metabolic pathways, notably the insulin signaling pathway..
https://www.eboro.cz
Re: Tropospheric ozone
O3
2025 Feb 13
Identifying the spatiotemporal patterns and natural and socioeconomic influencing factors of PM2.5 and O3 pollution in China
https://pubmed.ncbi.nlm.nih.gov/39946421/
..The results show that PM2.5 and O3 concentrations exhibit distinct monthly U-shaped and inverted U-shaped temporal fluctuation patterns across Chinese cities, respectively. ..
............................
5 May 2025
Comprehensive 24-hour ground-level ozone monitoring: Leveraging machine learning for full-coverage estimation in East Asia
https://www.sciencedirect.com/science/a ... 942500281X
Reversed urban-rural O3 patterns observed between day and night.
--------------------------------------------------------------------------
MS
2020 Oct
Prevalence of multiple sclerosis in rural and urban districts in Telemark county, Norway
https://pubmed.ncbi.nlm.nih.gov/32707528/
Conclusions: The prevalence of MS in Telemark is among the highest ever reported in Norway, consistent with an increasing incidence in the county over the past twenty years. The even higher prevalence in the rural areas is unlikely to be explained by possible risk factors like latitude, exposure to sunlight and diet. Further studies on differences between urban and rural areas are required to reveal possible new risk factors.
2025 Feb 13
Identifying the spatiotemporal patterns and natural and socioeconomic influencing factors of PM2.5 and O3 pollution in China
https://pubmed.ncbi.nlm.nih.gov/39946421/
..The results show that PM2.5 and O3 concentrations exhibit distinct monthly U-shaped and inverted U-shaped temporal fluctuation patterns across Chinese cities, respectively. ..
............................
5 May 2025
Comprehensive 24-hour ground-level ozone monitoring: Leveraging machine learning for full-coverage estimation in East Asia
https://www.sciencedirect.com/science/a ... 942500281X
Reversed urban-rural O3 patterns observed between day and night.
--------------------------------------------------------------------------
MS
2020 Oct
Prevalence of multiple sclerosis in rural and urban districts in Telemark county, Norway
https://pubmed.ncbi.nlm.nih.gov/32707528/
Conclusions: The prevalence of MS in Telemark is among the highest ever reported in Norway, consistent with an increasing incidence in the county over the past twenty years. The even higher prevalence in the rural areas is unlikely to be explained by possible risk factors like latitude, exposure to sunlight and diet. Further studies on differences between urban and rural areas are required to reveal possible new risk factors.
https://www.eboro.cz
Re: Tropospheric ozone
2025 Jan 31
Novel Triple-Oxygen Isotope Study Indicates Unprecedented Ozone-Particulate Interaction Pathways in Atmospheric Pollution Chemistry
https://pubmed.ncbi.nlm.nih.gov/39959052/
Novel Triple-Oxygen Isotope Study Indicates Unprecedented Ozone-Particulate Interaction Pathways in Atmospheric Pollution Chemistry
https://pubmed.ncbi.nlm.nih.gov/39959052/
https://www.eboro.cz
Re: Tropospheric ozone
O3
2009 Feb 6.
Ozone modulates IL-6 secretion in human airway epithelial and smooth muscle cells
https://pubmed.ncbi.nlm.nih.gov/19201813/
------------------------------------
Published: 05 March 2016
Sex-specific IL-6-associated signaling activation in ozone-induced lung inflammation
https://bsd.biomedcentral.com/articles/ ... 016-0069-7
---------------------------------------------------------------------------------
MS
1991 Feb
Interleukin-6 is elevated in plasma in multiple sclerosis
https://pubmed.ncbi.nlm.nih.gov/1991821/
--------------------
1997
IL-6 detection in multiple sclerosis brain
https://www.sciencedirect.com/science/a ... 0X96002833
--------------------
2025 Jan 27
Associations between IL-6 and trajectories of depressive symptoms across the life course: Evidence from ALSPAC and UK Biobank cohorts
https://pubmed.ncbi.nlm.nih.gov/39865800/
Conclusions: These findings suggest that systemic inflammation may influence the severity and course of depressive symptoms across the life course, which is apparent regardless of age and differences in measures and number of time points between these large, population-based cohorts.
2009 Feb 6.
Ozone modulates IL-6 secretion in human airway epithelial and smooth muscle cells
https://pubmed.ncbi.nlm.nih.gov/19201813/
------------------------------------
Published: 05 March 2016
Sex-specific IL-6-associated signaling activation in ozone-induced lung inflammation
https://bsd.biomedcentral.com/articles/ ... 016-0069-7
---------------------------------------------------------------------------------
MS
1991 Feb
Interleukin-6 is elevated in plasma in multiple sclerosis
https://pubmed.ncbi.nlm.nih.gov/1991821/
--------------------
1997
IL-6 detection in multiple sclerosis brain
https://www.sciencedirect.com/science/a ... 0X96002833
--------------------
2025 Jan 27
Associations between IL-6 and trajectories of depressive symptoms across the life course: Evidence from ALSPAC and UK Biobank cohorts
https://pubmed.ncbi.nlm.nih.gov/39865800/
Conclusions: These findings suggest that systemic inflammation may influence the severity and course of depressive symptoms across the life course, which is apparent regardless of age and differences in measures and number of time points between these large, population-based cohorts.
Last edited by Petr75 on Mon Mar 17, 2025 2:17 am, edited 1 time in total.
https://www.eboro.cz
Re: Tropospheric ozone
2025 Feb 19Petr75 wrote: ↑Wed Jun 19, 2024 12:12 pm O3
November 2019
sciencedirect.com
Weather, ambient air pollution, and risk of migraine headache onset among patients with migraine
https://www.sciencedirect.com/science/a ... 2019300662
-------------------------------------------------
MS
2024 Jun 14
Migraine Risk in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder: A Nationwide Cohort Study in South Korea
https://pubmed.ncbi.nlm.nih.gov/38880093/
Conclusion: The study results revealed an increased risk of migraines in patients with MS but not in patients with NMSOD compared with matched controls.
Migraines, the multiple sclerosis prodrome, and multiple sclerosis susceptibility
https://pubmed.ncbi.nlm.nih.gov/39968872/
Conclusion: Migraine was associated with an increased odds of MS only when co-occurrence was considered. These findings imply that migraines are part of the constellation of MS onset symptoms rather than a risk factor for or prodromal symptom of MS.
https://www.eboro.cz
Re: Tropospheric ozone
2024 Dec 30
Fine Scale Spatial and Temporal Allocation of NOx Emissions from Unconventional Oil and Gas Development Can Result in Increased Predicted Regional Ozone Formation
https://pubmed.ncbi.nlm.nih.gov/39975534/
Fine Scale Spatial and Temporal Allocation of NOx Emissions from Unconventional Oil and Gas Development Can Result in Increased Predicted Regional Ozone Formation
https://pubmed.ncbi.nlm.nih.gov/39975534/
https://www.eboro.cz
Re: Tropospheric ozone
O3
2025 Feb 18
Short-Term Associations Between Ambient Ozone and Acute Myocardial Infarction Onset Among Younger Patients: Results From the VIRGO Study
https://pubmed.ncbi.nlm.nih.gov/39968338/
------------------------------------
MS
November 2021
The prevalence of Myocardial Infarction among Multiple Sclerosis Patients: a Systematic Review and Meta-analysis
https://www.sciencedirect.com/science/a ... 4821005599
Highlights
•The overall prevalence of MI was 1.7% among MS patients.
•The pooled odds ratio estimate for MI was 1.4, indicating that MS increased the odds of MI by 41%.
2025 Feb 18
Short-Term Associations Between Ambient Ozone and Acute Myocardial Infarction Onset Among Younger Patients: Results From the VIRGO Study
https://pubmed.ncbi.nlm.nih.gov/39968338/
------------------------------------
MS
November 2021
The prevalence of Myocardial Infarction among Multiple Sclerosis Patients: a Systematic Review and Meta-analysis
https://www.sciencedirect.com/science/a ... 4821005599
Highlights
•The overall prevalence of MI was 1.7% among MS patients.
•The pooled odds ratio estimate for MI was 1.4, indicating that MS increased the odds of MI by 41%.
https://www.eboro.cz
Re: Tropospheric ozone
2025 Feb 18
Revealing the nonlinear responses of PM2.5 and O3 to VOC and NOx emissions from various sources in Shandong, China
https://pubmed.ncbi.nlm.nih.gov/39983648/
Revealing the nonlinear responses of PM2.5 and O3 to VOC and NOx emissions from various sources in Shandong, China
https://pubmed.ncbi.nlm.nih.gov/39983648/
https://www.eboro.cz
Re: Tropospheric ozone
2025 Feb 20
Ozone and nitrogen dioxide mediated protein multiphase reactions under ultraviolet radiation conditions
https://pubmed.ncbi.nlm.nih.gov/39986563/
..The results showed that O3 could significantly promote the degradation, nitration and oligomerization of BSA, indicating that O3 is the primary driver of the multiphase reactions.
Ozone and nitrogen dioxide mediated protein multiphase reactions under ultraviolet radiation conditions
https://pubmed.ncbi.nlm.nih.gov/39986563/
..The results showed that O3 could significantly promote the degradation, nitration and oligomerization of BSA, indicating that O3 is the primary driver of the multiphase reactions.
https://www.eboro.cz