Tropospheric ozone

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O3

2024 Apr 18
Long-term exposure to ambient ozone and adult-onset asthma: A prospective cohort study
https://pubmed.ncbi.nlm.nih.gov/38642637/

..Conclusion: Our findings suggest a potential causal relationship between long-term exposure to high-level ambient O3 and increased risks of AOA.
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MS

#ACTRIMS2019 – Asthma More Common in MS Patients Than Public at Large, Study Finds
https://multiplesclerosisnewstoday.com/ ... udy-finds/

.. Asthma is significantly more common among patients with multiple sclerosis (MS) than in the general population, a new study shows. The increased prevalence was especially evident in younger and elderly MS patients, regardless of race or sex.

2025 Apr 1
Early-Life Ozone Exposure and Asthma and Wheeze in Children
https://pubmed.ncbi.nlm.nih.gov/40172886/

Abstract
Importance: Ozone (O3) is the most frequently exceeded air pollutant standard in the US. While short-term exposure is associated with acute respiratory health, the epidemiologic evidence linking postnatal O3 exposure to childhood asthma and wheeze is inconsistent and rarely evaluated as a mixture with other air pollutants.

Conclusions and relevance: In this cohort study with relatively low ambient O3 exposure, early-life O3 was associated with asthma and wheeze outcomes at age 4 to 6 years and in mixture with other air pollutants but not at age 8 to 9 years. Regulating and reducing exposure to ambient O3 may help reduce the significant public health burden of asthma among US children.

2025 May
Global Trends in the Relationship Between Chronic Air Pollution Exposure, Physical Activity and Lung Function in Youth Aged 5-18 Years With and Without Asthma: A Systematic Review
https://pubmed.ncbi.nlm.nih.gov/40399510/

Background: Children are more susceptible to air pollution due, at least in part, to their less-developed respiratory systems and higher respiratory rates...

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2025 May 22
Deep learning-based forecasting of daily maximum ozone levels and assessment of socioeconomic and health impacts in South Korea
https://pubmed.ncbi.nlm.nih.gov/40409021/

..Significant correlations were found between O3 and female respiratory mortality (r = 0.53, ρ = 0.42; p = 0.020, 0.024), cardiovascular mortality in both genders, and male employment (r = 0.48, ρ = 0.76; p = 0.039, 0.0002)...

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O3

2023 Nov 29
School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China
Short-term exposure to ozone may trigger the onset of Kawasaki disease: An individual-level, case-crossover study in East China
https://pubmed.ncbi.nlm.nih.gov/38040257/

Abstract

Kawasaki disease (KD) is an acute, systemic vasculitis that primarily affects children aged under the age of 5. While environmental factors have been linked to the development of KD, the specific role of ozone (O3) pollution in triggering the disease onset remains uncertain. This study aimed to examine the associations between short-term O3 exposure and KD onset in children. ....Our findings revealed a significant association of O3 exposure with KD onset on the day of onset(lag 0 day) ...
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2020 Aug 9
Danish Cancer Society Research Center, Copenhagen, Denmark
Kawasaki disease, autoimmune disorders, and cancer: a register-based study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415012/

...Studies indicate that KD is triggered by an abnormal autoimmune response caused by an infection [7–9], but no definitive agent has been found. The potent anti-inflammatory effect of immunoglobulin treatment in the early stages of the disease indicates that autoimmunity or auto-inflammation could be essential in KD [10, 11], which one of these factors that are the most important has not been clarified [10]. However, this observation could suggest that KD might be a severe autoimmune manifestation in a child predisposed to other autoimmune diseases later in life. Yet, no long-term follow-up studies have yet investigated this theory.

2025 May 13
Ozone exposure is positively correlated with the occurrence of Kawasaki disease in Chinese children
https://pubmed.ncbi.nlm.nih.gov/40360775/

..Our findings explain the association between O3 exposure and the incidence of KD, and further analyze the regulatory role of clinical indicators in the association. It is helpful to provide theoretical support for subsequent research.

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November 2014
Ozone (O3) elicits neurotoxicity in spinal cord neurons (SCNs) by inducing ER Ca2 + release and activating the CaMKII/MAPK signaling pathway
https://www.sciencedirect.com/science/a ... 8X14003160

[iAbstract
Ozone (O3) is widely used in the treatment of spinal cord related diseases. Excess or accumulation of this photochemical air can however be neurotoxic. In this study, in vitro cultured Wister rat spinal cord neurons (SCNs) were used to investigate the detrimental effects and underlying mechanisms of O3. Ozone in a dose-dependent manner inhibited cell viability at a range of 20 to 500 μg/ml, with the dose at 40 μg/ml resulting in a decrease of cell viability to 75%. The cell death after O3 exposure was related to endoplasmic reticulum (ER) calcium (Ca2 +) release. Intracellular Ca2 + chelator[/i]..

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2025 May 9
Progressive Elevation of Store-Operated Calcium Entry-Associated Regulatory Factor (SARAF) and Calcium Pathway Dysregulation in Multiple Sclerosis
https://pubmed.ncbi.nlm.nih.gov/40429665/

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2025 Apr 30
Respiratory Function Laboratory, 1st Department of Respiratory Medicine, Sotiria Hospital, Medical School, National and Kapodistrian University of Athens, Greece
Air Pollution and Effects of Tropospheric Ozone (O3) on Public Health
https://pubmed.ncbi.nlm.nih.gov/40427825/

Abstract

Air pollution is a significant and widespread issue that presents serious challenges for both human health and the environment because of the presence of a variety of harmful substances in the air, such as tropospheric ozone (O3), particulate matter (PM10), nitrogen oxides (NOx), sulfur dioxide (SO2), and carbon monoxide (CO). In this research, the aim is to evaluate the current evidence for the harmful effects of air pollution on human health, focusing on tropospheric ozone, and to highlight the need for further research in the future. The objective is to evaluate recent data on the respiratory and cardiovascular risks caused by air pollution, the potential association between climate change due to air pollution and human disorders, and the subsequent economic burden. A systematic search of the literature is conducted using PubMed, Scopus, Web of Science, and regulatory reports (EPA), focusing on peer-reviewed studies, epidemiological analyses, and clinical and experimental studies. The key findings indicate that O3 exposure contributes to inflammatory lung injury and to the worsening of preexisting conditions like asthma and COPD, is associated with cancer, and also has numerous negative impacts on neurological, metabolic, and reproductive health, combined with increased healthcare costs. These findings highlight the significance of O3 pollution as a major public health concern, emphasizing the need for immediate measures to decrease emissions and effective policies to protect the climate and the health of the individuals.

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O3

2025 May 22
Ambient air pollution and hospitalisation for epilepsy in China: A nationwide, individual-level case-crossover study
https://pubmed.ncbi.nlm.nih.gov/40424805/

..This individual-level, nationwide case-crossover study provides the first evidence that short-term exposure to NO2 and O3 elevates the risk of epilepsy-related hospitalisations. These findings underscore the need for stricter air quality standard to mitigate the detrimental effects of air pollution on CNS diseases.

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MS

July 08, 2020
Mayo Clinic
Is there any connection between multiple sclerosis and epilepsy?
https://www.mayoclinic.org/diseases-con ... q-20058138

Epileptic seizures are more common in people who have multiple sclerosis (MS) than in those who don't have MS. While it's estimated that less than 3 percent of people without MS have seizures, about 2 to 5 percent of people with MS are thought to have active seizures.

Exactly why these seizures occur more often in people with MS isn't completely understood. MS lesions in certain areas of the brain might trigger these seizures. However, lesions are very common in MS, and seizures are unusual, so there are probably other factors that play a role in seizures, too.

Seizures may be the first noticeable sign of MS before diagnosis. Seizures can also occur during times when MS symptoms flare up. In some cases, seizures might be the only sign of an MS flare. But, the majority of seizures occur unrelated to MS relapses, and the occurrence of a seizure soon before diagnosis of MS may just be a chance occurrence.

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2025 Apr 23
Key Laboratory for Yellow River and Huai River Water Environment and Pollution Control, Ministry of Education, School of Environment, Henan Normal University, Xinxiang, China
Evidence for Coordinated Control of PM2.5 and O3: Long-Term Observational Study in a Typical City of Central Plains Urban Agglomeration
https://pubmed.ncbi.nlm.nih.gov/40423409/

Abstract

Fine particulate matter (PM2.5) and Ozone (O3) pollution have emerged as the primary environmental challenges in China in recent years. Following the implementation of the Air Pollution Prevention and Control Action Plan, a substantial decline in PM2.5 concentrations was observed, while O3 concentrations exhibited an increasing trend across the country...