ozone

[Petr75]

2025 Jun 25
Ozone rectal insufflation inhibits the development of atherosclerosis in ApoE-/-mice, which is mediated by the regulation of gut microbiota and metabolites
https://pubmed.ncbi.nlm.nih.gov/40636499/

Results: O3-RI reduced serum LDL-C levels by approximately 29.6% and decreased both atherosclerotic lipid areas and plaque area in ApoE-/- mice. Additionally, O3-RI improved gut microbiota imbalance caused by a high-fat diet in these mice. Notably, O3-RI increased beneficial microorganisms like Lactobacillus and Bifidobacterium, which help reduce atherosclerosis. Additionally, O3-RI also increased the levels of short-chain fatty acids, such as propionic acid and butyric acid, At the same time, it decreased harmful microbial metabolites, like TMA and TMAO in fecal samples.

Discussion: This research indicates that O3-RI effectively inhibits atherosclerosis and reduces serum LDL-C levels. These effects are likely linked to ozone's optimization of gut microbiota and regulation of microbial metabolites in ApoE-/- mice. The non-invasive O3-RI may play a crucial role in managing and treating atherosclerosis.