Summary of the pipeline

[dignan]

I removed SGN-30 from the list (phase 1) since Seattle Genetics no longer makes any mention of multiple sclerosis on their website (that I could find).

[dignan]

I removed A4I from the list in phase 2 because according to clinicaltrials.gov, the trial was withdrawn before recruitment started.

[seeva]

Gee Arron...I don't know what to say...you're great...really...but my girlfriend and I are pretty serious...anywho...

I'm glad you like it. Of course you can do whatever you like with the list. I don't need to be credited.

hi dignan please let me know any ms drug under tril for primary or secondary progressive type of multiple sclerosis. according my neurology the new tysabri is only treatment for relapsing-remitting multiple sclerosis.
regards
seeva :roll:

[dignan]

Seeva, here's a bit of a progressive pipeline list for phase's 2 and 3 (the time line for approval of these ranges from rituxan which could be approved this year, to maybe 6-7 years for drugs just entering phase 2 trials):

Phase 3:
- MBP8298 (BioMS) (trial for SPMS)
- Revimmune (aka high dose cyclophosphamide or cytoxan) (Accentia Biopharmaceuticals) (refractory MS - includes SPMS I think, not sure about PPMS)
- Rituximab (aka Rituxan) (Biogen / Genentech) (trial for PPMS)
- Stem cells - autologous hematopoietic (ASTIMS trial)

Phase 2:
- Cannabinoids - oral (PPMS) (Clinical Neurology Research Group - Plymouth)
- Fluoxetine (aka Prozac) (SP, PP & RRMS) (University Medical Center Groningen)
- GEM-SP (SPMS) (Gemacbio)
Lamotrigine (aka Lamictal) (SPMS) (Glaxosmithkline)
- Lipoic acid (with interferon beta) (SPMS) (OHSU)
- Lymphocytapheresis, azathioprine & prednisone (SPMS) (U of Chicago)
- Mesenchymal Stem Cells (University of Cambridge)
- Pirfenidone (aka Deskar) (Intermune) (trial for SPMS complete)
- Pixantrone (aka BBR 2778) (Cell Therapeutics)
- Treosulfan (SPMS) (University of Wuerzburg, Germany)

[dignan]

The CUPID study of cannabinoids (currently on the list in phase 2) in the UK is:

- double-blind
- placebo-controlled
- multi-centre
- 3 years in duration
- and is aiming for enrollment of 500 people

I keep looking for some mention of what phase trial this is but can't find any. So, if it looks like a duck, walks like a duck and quacks like a duck, I'm going to call it a duck...in this case, a phase 3 trial.

http://www.pms.ac.uk/cnrg/cupid.php

[Lyon]

.

[Jean]

About Gemacbio's GEM-SP, I had recently an e-mail contact from a member of the board. She told me the pipeline was in "stand-by" because of a lack of funding. Next step would be a phase IIb.

[Lyon]

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[dignan]

I added Ocrelizumab (R1594) (Roche/Genentech/Biogen) to the list in phase 2. It's been discussed a bit in the last few months. It has the same CD20 target as rituxan and there has been some debate between the companies on how to proceed with trials, but I think they have been resolved now.

Roche phase 2 pipeline

[Jamie]

Here's a fun little exercise...

There are 40 substances in Phase II right now. Through the 90's, about 40% of drugs tested in Phase II moved on to Phase III trials. So using those stats that means about 16 of the current 40 substances being tested for MS would likely move on to Phase III trials.

There are 7 substances currently in Phase III trials and I assume Tysabri will either be pulled, or will be back on the market by early next year. The remaining 6 substances in Phase III will be there until AT LEAST the end of 2007.

So, it's quite possible that in 2008, there will be over 20 treatments for MS that will be in Phase III trials. So many that it may actually get hard to keep up with everything in Phase III. A change I look forward to.

Interesting that , now in 2008 there are 17 phase III's on your trial list.

Kinda cool, like time travel, catching up with all these posts.

[dignan]

Thanks for pointing that out. I'm pretty amazing at predicting the future correctly...Anybody want to buy some beta video tapes? I've got lots.

[Lyon]

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[dignan]

I have been looking for signs of life from the Topiramate (aka Topamax) (with Avonex) phase 2 trial, but can't find any information from the last 2 years. I am taking it off the list. Please let me know if I'm wrong.

[Smilingface]

What do you think about adding FTY 720 or fingolimod to the list?

In addition to it's well known mechanism of sequestering lymphocytes in lymph nodes, research is showing this drug may promote nerve repair by recruiting oligodendrocytes.

Long anticipated Phase III trial for PPMS'ers is coming. Really.

I've added the herb Cordyseps whch is the basis of FTY 720 to my regiment
just for good measure! You never know.......

[dignan]

FTY720 for RRMS is there in phase 3, but I'd like to see some mention of the PPMS trial from Novartis before adding that one to the list.