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2024 Aug 6
Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA
Multiple metal exposures associate with higher amyotrophic lateral sclerosis risk and mortality independent of genetic risk and correlate to self-reported exposures: a case-control study
https://pubmed.ncbi.nlm.nih.gov/39107037/

Conclusion: Metals in plasma and urine associated with increased ALS risk and reduced survival, independent of genetic risk, and correlated with occupational and non-occupational metal exposures. These data underscore the significance of metal exposure in ALS risk and progression.

2024 Nov 18
Early life events may be the first steps on the multistep path to amyotrophic lateral sclerosis
https://pubmed.ncbi.nlm.nih.gov/39557859/

Abstract
A combination of multiple genetic and environmental factors appear to be required to trigger the onset of amyotrophic lateral sclerosis (ALS). Early life environmental exposures have been reported to be risk factors for a variety of adult-onset diseases, so we used data from an online international ALS case-control questionnaire to estimate whether any of these could be risk factors for the clinical onset of ALS. ..