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2023 Aug 1
Oak Ridge Institute for Science and Education, Oak Ridge, USA Effects of Controlled Ozone Exposure on Circulating microRNAs and Vascular and Coagulation Biomarkers: A Mediation Analysis https://pubmed.ncbi.nlm.nih.gov/37624035/
...Mediation analysis showed that miR-19a-3p may be a significant mediator of O3-exposure-induced changes in blood TNFα levels
...The results showed that the expression level of multiple circulating miRNAs (e.g., miR-19a-3p, miR-34a-5p) was significantly associated with O3 exposure
...Blood samples from 40 RRMS patients and 20 healthy volunteers were investigated. The expression levels of miR-34a, miR-199a, miR-30c, and miR-19a, and the percentage of Th17 and Treg cells were measured.
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2018 Jun 15 Analysis of the expression of mir-34a, mir-199a, mir-30c and mir-19a in peripheral blood CD4+T lymphocytes of relapsing-remitting multiple sclerosis patients https://pubmed.ncbi.nlm.nih.gov/29551498/
Re: Tropospheric ozone
Posted: Fri Sep 01, 2023 4:55 am
by Petr75
2023 Aug 29
Department of Pharmacology, SRM College of Pharmacy, SRMIST, Kattankulathur, Kancheepuram, Tamil Nadu, Indi OZONE-INDUCED NEUROTOXICITY: IN VITRO AND IN VIVO EVIDENCE https://pubmed.ncbi.nlm.nih.gov/37652313/
Abstract
Together with cities in higher-income nations, it is anticipated that the real global ozone is rising in densely populated areas of Asia and Africa. This review aims to discuss the possible neurotoxic pollutants and ozone-induced neurotoxicity: in vitro and in vivo, along with possible biomarkers to assess ozone-related oxidative stress. As a methodical and scientific strategy for hazard identification and risk characterization of human chemical exposures, toxicological risk assessment is increasingly being implemented. While traditional methods are followed by in vitro toxicology, cell culture techniques are being investigated in modern toxicology. In both human and rodent models, aging makes the olfactory circuitry vulnerable to spreading immunological responses from the periphery to the brain because it lacks the blood-brain barrier. The ozone toxicity is elusive as it shows ventral and dorsal root injury cases even in the milder dose. Its potential toxicity should be disclosed to understand further the clear mechanism insights of how it acts in cellular aspects. Human epidemiological research has confirmed the conclusions that prenatal and postnatal exposure to high levels of air pollution are linked to behavioral alterations in offspring. O3 also enhances blood circulation. It has antibacterial action, which may have an impact on the gut microbiota. It also activates immunological, anti-inflammatory, proteasome, and growth factor signaling Prolonged O3 exposure causes oxidative damage to plasma proteins and lipids and damages the structural and functional integrity of the mitochondria. Finally, various studies need to be conducted to identify the potential biomarkers associated with ozone and the brain.
Re: Tropospheric ozone
Posted: Tue Sep 05, 2023 5:54 am
by Petr75
2023 Sep 4
Institute of Child and Adolescent Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, China Interaction between ozone and paternal smoking on fetal congenital heart defects among pregnant women at high risk: a multicenter maternal-fetal medicine study https://pubmed.ncbi.nlm.nih.gov/37665504/
Conclusions: Maternal O3 exposure and paternal smoking were interactively associated with an increased risk of fetal CHD in offspring, which calls for effective measures to decrease maternal exposure to O3 pollution and secondhand smoke for CHD prevention.
Re: Tropospheric ozone
Posted: Tue Sep 05, 2023 6:18 am
by Petr75
O3
2023 Sep 2
School of Public Health, Xinxiang Medical University, Xinxiang, China High temperature exacerbates ozone-induced airway inflammation: Implication of airway microbiota and metabolites https://pubmed.ncbi.nlm.nih.gov/37666337/
...Short-term exposure to ozone (O3) has been associated with airway inflammation. Given that high temperature (HT) accelerates O3 production, it is of significance to determine whether co-exposure to HT exacerbates O3-induced airway inflammation...
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MS
2023 Sep 4
Department of Pharmacy, International Islamic University Chittagong, Bangladesh Role of Th17 and IL-17 Cytokines on Inflammatory and Auto-immune Diseases https://pubmed.ncbi.nlm.nih.gov/37670700/
...Results: IL-17 cytokines, particularly IL-17A, have been implicated in the development of various inflammatory and autoimmune disorders
..The mechanisms underlying ozone (O3)-induced pulmonary inflammation remain unclear. Interleukin-10 (IL-10) is an anti-inflammatory cytokine that is known to inhibit inflammatory mediators.
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2023 Aug 3
Department of Immunology, University of Toronto, Toronto, ON, Canada Under the influence: environmental factors as modulators of neuroinflammation through the IL-10/IL-10R axis https://pubmed.ncbi.nlm.nih.gov/37600781/
Re: Tropospheric ozone
Posted: Mon Sep 11, 2023 8:43 am
by Petr75
O3
2012 Jun
Department of Otolaryngology, Head and Neck Surgery, University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstr, Mainz, Germany Impact of ozone exposure on prostaglandin release in nasal polyps https://pubmed.ncbi.nlm.nih.gov/22130916/
...Ozone is an air pollutant with known proinflammatory effects on exposed epithelia, however, its impact on the expression of the cyclooxygenases 1 and 2 (cox1/2) and prostaglandin
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MS
2023 Aug 24
Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, China The causal relationship between multiple autoimmune diseases and nasal polyps https://pubmed.ncbi.nlm.nih.gov/37691921/
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2020
Department of Biotechnology and Bioinformatics, Yogi Vemana University, Kadapa, India Role of Prostaglandins in Multiple Sclerosis https://pubmed.ncbi.nlm.nih.gov/31914903/
Re: Tropospheric ozone
Posted: Mon Sep 11, 2023 11:07 am
by Petr75
Re: Tropospheric ozone
Posted: Mon Sep 11, 2023 11:36 am
by Petr75
MS
2023 Aug 10
Department of Neurology, Sichuan Taikang Hospital, Chengdu, Sichuan, China Unraveling the link: exploring the causal relationship between diabetes, multiple sclerosis, migraine, and Alzheimer's disease through Mendelian randomization https://pubmed.ncbi.nlm.nih.gov/37694124/
...In addition, traffic-related pollutants, such as ozone precursors and carbon monoxide, are known to induce migraine headache, particularly in cold climates
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2018
Université Claude Bernard Lyon 1, INSERM, CNRS, Lyon Neuroscience Research Center, Lyon, France Ozone Atmospheric Pollution and Alzheimer's Disease: From Epidemiological Facts to Molecular Mechanisms https://pubmed.ncbi.nlm.nih.gov/29480184/
.....More recently, the potential deleterious effect of air pollution inhalation on the central nervous system was also investigated and mounting evidence supports a link between air pollution exposure and neurodegenerative pathologies, especially Alzheimer's disease (AD).
Re: Tropospheric ozone
Posted: Thu Sep 14, 2023 7:32 am
by Petr75
O3
2023 Sep 6
Department of Respiratory Medicine, Traditional Chinese Medicine Hospital of Hebei Province, Shijiazhuang, People's Republic of China Ozone Pollution and Acute Exacerbation of Asthma in Residents of China: An Ecological Study https://pubmed.ncbi.nlm.nih.gov/37700876/
2023 Sep 7
School of Health and Environmental Science & Department of Health and Safety Convergence Science, Korea University , Republic of Korea Visualizing indoor ozone exposures via o-dianisidine based colorimetric passive sampler https://pubmed.ncbi.nlm.nih.gov/37703734/
Re: Tropospheric ozone
Posted: Thu Sep 14, 2023 10:25 pm
by Petr75
Re: Tropospheric ozone
Posted: Thu Sep 14, 2023 10:33 pm
by Petr75
O3
2020 Jul
Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, Ludwig Maximilian University of Munich; Comprehensive Pneumology Center (CPC) Munich, Member DZL, German Center for Lung Research, Munich, Germany Depression and anxiety with exposure to ozone and particulate matter: An epidemiological claims data analysis https://pubmed.ncbi.nlm.nih.gov/32442925/
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MS
2023 Aug 29
College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia The prevalence of major depression and generalized anxiety disorder in patients with multiple sclerosis in Saudi Arabia: a cross-sectional multicentered study https://pubmed.ncbi.nlm.nih.gov/37706033/
2023 Aug
Neurology Clinic Tsudanuma & Dowakai Chiba Hospital Funabashi, Japan Gastrointestinal Dysfunction in Multiple Sclerosis and Related Conditions https://pubmed.ncbi.nlm.nih.gov/37703888/