This Is MS Multiple Sclerosis Knowledge & Support Community

Address of the person responsible for updating the info.:

h.kavnoudias@alfred.org.au

http://multiplesclerosisnewstoday.com/2 ... -patients/

However, while the debate over CCSVI and MS continues, new data suggests that Dr. Zamboni may have gotten it right in looking at the veins for treatment, but it might not be venous abnormalities that are the real problem, with a team of California-based researchers contending that it is the nerves surrounding the veins not the veins themselves that are being treated by ballooning, with expansion of the jugular vein leading to stimulation of the autonomic nerve fibers, which run alongside the jugular and are responsible for communication between the brain and the central nervous system. They say that ongoing research and a growing body of clinical data strongly indicate that Dr. Zamboni’s CCSVI procedure may be the first viable treatment for an even more pervasive problem — dysautonomia — which is seen not only in almost all MS patients but also in patients diagnosed with a long list of other diseases and conditions. As a result, they believe the CCSVI procedure is better described by the term TVAM (Transvascular Autonomic Modulation).

Transvascular Autonomic Modulation: A Modified Balloon Angioplasty Technique for the Treatment of Autonomic Dysfunction in Multiple Sclerosis Patients

Conclusion: The combination of balloon angioplasty of anatomically normal veins coupled with external compression during dilation of these veins can improve indicators of ANS dysfunction. The safety and efficacy of TVAM in MS patients observed in this pilot study is encouraging, paving the way for the treatment of dysautonomia in pathological states other than MS. Further studies should investigate TVAM in a larger MS cohort.

I was searching Alzheimer's Disease, and I was delighted to see CCSVI noted, with the statement

"It is possible that this is also the cause of neurodegeneration in AD. "

Which followed a summary of CCSVI in MS "This theory holds that increased venous pressure could be the main reason for the formation of colloids, lymphocyte and erythrocyte extravasation, promoting an inflammatory reaction in the brain and spine in cases of MS"

Then they put together a nice table, 8 CCSVI papers by 7 different authors, using 7 different measurement techniques.

Interesting to see that someone from outside the USA neurology lockbox, an author in Kenya from another neuro disease specialty, appears to find the CCSVI MS theory perfectely plausible, and supportive of one of the theories on AD. He also summarizes the history of theories on AD. That's how MS researchers should approach it, that CCSVI is a new and plausible theory that needs to be lined up against the old theories.

It's been 7 years. Are we there yet? Are there any countires yet where CCSVI treatment is now a normal practice of medicine for MS?

Hope all of us CCSVI-ers are doing well!

==========================================
A Current Understanding of Alzheimer's Disease and the Prospects of Phytopharmacological Intervention as a Management Strategy.

Journal: Juma, J Neurol Disord 2015, 3:4
Author Juma KK*
Department of Biochemistry and Biotechnology, Kenyatta University, Nairobi, P.O. Box 43844-00100, Kenya

http://www.esciencecentral.org/journals ... 000244.pdf

i'm out of the loop. thoughts on these?

Extracranial Venous abnormalities: A true pathological finding in patients with multiple sclerosis or an anatomical variant?
http://link.springer.com/article/10.100 ... 016-4314-6

Impaired Neurovisceral Integration of Cardiovascular Modulation Contributes to Multiple Sclerosis Morbidities
http://link.springer.com/article/10.100 ... 015-9599-y

Venous compression syndrome of internal jugular veins prevalence in patients with multiple sclerosis and chronic cerebro-spinal venous insufficiency.
https://www.ncbi.nlm.nih.gov/pubmed/27842009

"• The venous anatomy of the neck in patients without MS demonstrates multiple variants

• Asymmetry and stenoses of the internal jugular veins are common

• Collateral neck veins are not uncommon in patients without MS

• These findings do not support the theory of chronic cerebrospinal venous insufficiency"

This is an obvious non-sequitur that has been stated many times before. Because there is wide variation in normal people (as we all know) it does not follow that no variation can possibly be pathological. It just means it is necessary to be able to identify what is and what is not pathological variation.

If you look at maps of city center streets in any country you will find the pattern of streets shows infinite variation (far greater than you find in peoples' necks.) Does it therefore follow that traffic jams are impossible? Clearly nonsense.

jimmylegs wrote:i'm out of the loop. thoughts on these?

Extracranial Venous abnormalities: A true pathological finding in patients with multiple sclerosis or an anatomical variant?
http://link.springer.com/article/10.100 ... 016-4314-6

Impaired Neurovisceral Integration of Cardiovascular Modulation Contributes to Multiple Sclerosis Morbidities
http://link.springer.com/article/10.100 ... 015-9599-y

Venous compression syndrome of internal jugular veins prevalence in patients with multiple sclerosis and chronic cerebro-spinal venous insufficiency.
https://www.ncbi.nlm.nih.gov/pubmed/27842009

.
Impaired Neurovisceral Integration of Cardiovascular Modulation Contributes to Multiple Sclerosis Morbidities
http://link.springer.com/article/10.100 ... 015-9599-y
"We show that MS inflammatory and neurodegenerative processes are intertwined with the aforementioned clinical morbidities and are collectively the manifestations of cardiovascular autonomic nervous system (ANS) dysfunction. Similar strategies could be applied to other autoimmune and neurodegenerative diseases where autonomic imbalance plays a role."

See http://www.mscureenigmas.net/ms.../dr-o ... -ms-soluti...

OR http://www.mscureenigmas.net, blog post "Dr. Owiesy's Superior CCSVI-MS Solution" Feb 12, 2017

Consider Dr. Owiesy’s idea, that a “vasospasm” of the vein’s smooth muscle cells closes off the blood flow, that the problem arises exterior to the vein, not inside it. Relief of the spasm would open the blood flow. Therefore, the distinguishing factor is not the venous system per se but the “autonomic nervous system (ANS) dysfunction”. Deriving his treatment for CCSVI-MS from his work on migraines and Trigeminal Neuralgia (Tic Doulereux) Dr. Owiesy administers a sterile mixture of dexamethasone/lidocaine/thiamine directly into the peri-venous space of the Internal Jugular Veins.
It may be that “MS” veins are particularly weak, or the nervous system dysfunctional so that the structure/appearance of the veins is irrelevant.

Regards, Vesta

A therapy that opens up narrowed veins from the brain and spinal cord has been found non-effective in treating multiple sclerosis (MS), according to a study led by the University of British Columbia and Vancouver Coastal Health...Read more - http://www.ms-uk.org/controversial-libe ... -ms-090317

Impaired Neurovisceral Integration of Cardiovascular Modulation Contributes to Multiple Sclerosis Morbidities
http://link.springer.com/article/10.100 ... 015-9599-y
"We show that MS inflammatory and neurodegenerative processes are intertwined with the aforementioned clinical morbidities and are collectively the manifestations of cardiovascular autonomic nervous system (ANS) dysfunction. Similar strategies could be applied to other autoimmune and neurodegenerative diseases where autonomic imbalance plays a role.

Oh that is interesting, I'd missed that one.

HI Friends please read
http://ccsviaustralia.com.au/ccsvi-dont-throw-book-yet/
regards
seeva

seeva wrote:HI Friends please read
http://ccsviaustralia.com.au/ccsvi-dont-throw-book-yet/

This is likely the biggest criticism...

Vascular experts, Neurologists and people with MS/CCSVI have raised concerns about this study and they fall into three main areas:

There was no evidence provided that venous abnormalities were corrected by the procedure or that restenosis did not occur during the 48 week observation period.

So, what's the point in doing the study if you don't even bother to check the patient's veins following the venoplasty? Unless, of course, you want the study to fail and hope that the journal reviewers are too sleep deprived to balk at this obvious shortcoming.

Ccsvi Clinic in Wroclaw, Poland is actually doing research in which we are trying to check if restoring correct blood circulation make an improvent in patients' neurogical contition.
The Clinic uses the highest-class technology to diagnose vascular pathologies invisible for standard procedures so we can exactly identify where is the problem.

Most clinical trials concerning relationship beetwen CCSVI and MS are focused on jugular veins. But what about cerebral veins and sinuses? If the demyelination process affects brain and spine, maybe we should consider if veins that directly supply these structures are the main cause of development of neurodegenerative diseases.