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25 March 2024
Science of The Total Environment, sciencedirect.com TRPA1-PI3K/Akt-OPA1-ferroptosis axis in ozone-induced bronchial epithelial cell and lung injury https://www.sciencedirect.com/science/a ... 9724008076
Highlights
• Acute ozone exposure causes bronchial epithelial cell and lung injury.
•Acute ozone exposure activates TRPA1 through PI3K/Akt, disrupts mitochondrial function, and leads to ferroptosis.
•Mitochondrial fusion protein--OPA1 is essential in regulating mitochondrial function and ferroptosis.
•Ferroptosis plays an important role in acute ozone exposure-induced lung injury.
•TRPA1 is a novel ferroptosis regulator in ozone-induced bronchial epithelial cell and lung injury.
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MS
2024 May
Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China Role of ferroptosis in neuroimmunity and neurodegeneration in multiple sclerosis revealed by multi-omics data https://pubmed.ncbi.nlm.nih.gov/38801304/
..Our findings revealed that among seven sampling regions of different white matter lesions, the edges of active lesions exhibited the highest ferroptosis score, which was associated with activation of the phagocyte system. Remyelination lesions exhibit the lowest ferroptosis score. In the cortex, ferroptosis score were elevated in neurons, relevant to a variety of neurodegenerative disease-related pathways.
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2023 May 30 Neuropathic-like Nociception and Spinal Cord Neuroinflammation Are Dependent on the TRPA1 Channel in Multiple Sclerosis Models in Mice https://pubmed.ncbi.nlm.nih.gov/37296632/
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..Exposure to PM2.5, PM10, and O3 was associated with physical, psychological, and social frailty and low physical performance in Korean older adults aged ≥ 70
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MS
2024 May 27 Falls, fracture and frailty risk in multiple sclerosis: a Mendelian Randomization study to identify shared genetics https://pubmed.ncbi.nlm.nih.gov/38801451/
..Conclusion: We found potential pleiotropic genetic effects between MS and falls. However, our analysis did not reveal a causal relationship between MS and increased risks of falls, fractures, or frailty. This suggests that the musculoskeletal disorders frequently reported in MS patients in clinical studies are more likely attributed to secondary factors associated with disease progression and treatment, rather than being directly caused by MS itself.
Human exposure to ozone is associated with increased prevalence of allergic asthma. Here, we demonstrate that ozone increases levels of activated dendritic cells in thoracic lymph nodes and promotes allergic sensitization through a TLR4-dependent pathway.
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MS
2024 May 30 Quercetin regulates dendritic cell activation by targeting STAT4 in the treatment of experimental autoimmune encephalomyelitis https://pubmed.ncbi.nlm.nih.gov/38823456/
Abstract
Multiple sclerosis (MS) is a class of autoimmune diseases mainly caused by the immune system attacking the myelin sheath of the axons in the nervous system. Although the pathogenesis of MS is complex, studies have shown that dendritic cells (DCs) play a vital role in the pathogenesis of MS. Quercetin (QU) has a unique advantage in clinical application, especially for treating autoimmune diseases. However, the mechanism of QU in the treatment of experimental autoimmune encephalomyelitis (EAE) remains unclear. In this study, we explore the potential role of QU in EAE. Finally, we find that QU has anti-inflammatory activities and neural protective effects in EAE. The experimental results suggest that the cellular basis for QU's function is to inhibit the activation of DCs while modulating the Th17 cell differentiation in the co-culture system. Further, QU may target STAT4 to inhibit its activation in DCs. This work will be of great significance for the future development and utilization of QU.
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... Toll-like receptors (TLR) play a critical role in modulating cytokine and chemokine secretion in response to exogenous Pathogen Associated to Molecular Patterns and endogenous Danger
•Electronic spectroscopy has shown that the O3 attack is directed essentially toward the aromatic amino acid units of proteins. The most sensitive is tryptophan followed by tyrosine while phenylalanine appears much less reactive (see Scheme
Probably also histidine should react quite well with O3 (see Scheme 1) but we do not have any direct evidence of this
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..In recent years, cumulative research has brought attention to the link between neuroinflammation and neurodegeneration through metabolic activation and dysregulation of the kynurenine pathway (KP) of tryptophan metabolism
2024 Jun 1
State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University, China Ozone sensitivity regimes vary at different heights in the planetary boundary layer https://pubmed.ncbi.nlm.nih.gov/38830412/
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2024 Jun 3
Inserm, France Cohortes, Paris, France Geographic sources of ozone air pollution and mortality burden in Europe https://pubmed.ncbi.nlm.nih.gov/38830993/
Abstract
Ground-level ozone (O3) is a harmful air pollutant formed in the atmosphere by the interaction between sunlight and precursor gases. Exposure to current O3 levels in Europe is a major source of premature mortality from air pollution
..Exposure to PM2.5, PM10, and O3 was associated with physical, psychological, and social frailty and low physical performance in Korean older adults aged ≥ 70
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MS
2024 May 27 Falls, fracture and frailty risk in multiple sclerosis: a Mendelian Randomization study to identify shared genetics https://pubmed.ncbi.nlm.nih.gov/38801451/
July 2020
sciencedirect.com Depression and anxiety with exposure to ozone and particulate matter: An epidemiological claims data analysis
... the results of our analyses based on 1.13 million individuals from the general population support the notion that long-term elevated ozone and PM10 levels increase the risk of depression and anxiety independently from each other.
2024 May 22
Department of Occupational Therapy Education, School of Health Professions, University of Kansas Medical Center, Kansas, KS, United States Mental health and frailty in people with multiple sclerosis: unraveling a complex relationship https://pubmed.ncbi.nlm.nih.gov/38840749/
Re: Tropospheric ozone
Posted: Sat Jun 08, 2024 7:03 am
by Petr75
Re: Tropospheric ozone
Posted: Sat Jun 08, 2024 11:58 am
by Petr75
2024 Jun 4 Association of short-term exposure to ambient fine particulate matter and ozone with outpatient visits for anxiety disorders: A hospital-based case-crossover study in South China https://pubmed.ncbi.nlm.nih.gov/38844166/
Conclusion: Short-term exposure to ambient PM2.5 and O3 was significantly associated with a higher odds of outpatient visits for ADs, which can contribute to considerable excess outpatient visits.
Conclusions— Observational data confirm that short-term O3 exposure within a period of 1 to 2 days is related to acute coronary events in middle-aged adults without heart disease, whereas NO2 and SO2 are not.
2024 Jun 7
Department of Geriatric Cardiology, General Hospital of Southern Theater Command, Guangzhou, China Causal effects for neurodegenerative diseases on the risk of myocardial infarction: a two-sample Mendelian randomization study https://pubmed.ncbi.nlm.nih.gov/38850523/
.. Abstract
Several studies have demonstrated a correlation between neurodegenerative diseases (NDDs) and myocardial infarction (MI), yet the precise causal relationship between these remains elusive. This study aimed to investigate the potential causal associations of genetically predicted Alzheimer's disease (AD), dementia with Lewy bodies (DLB), Parkinson's disease (PD), and multiple sclerosis (MS)
MR analyses, no horizontal pleiotropy or statistical heterogeneity was observed (all P>0.05). Additionally, results from MRPRESSO and leave-one-out sensitivity analysis confirmed the robustness of the causal effect estimations for genetically predicted AD, DLB, PD, and MS on MI. This study provides further support for the causal effects of AD on MI and, for the first time, establishes robust causal evidence for the detrimental effect of DLB on the risk of MI. Our findings emphasize the importance of monitoring the cardiovascular function of the elderly experiencing neurodegenerative changes.
Overpopulation and industrial growth result in an increase in air pollution, mainly due to suspended particulate matter and the formation of ozone. Repeated exposure to low doses of ozone, such as on a day with high air pollution levels, results in a state of chronic oxidative stress, causing the loss of dendritic spines, alterations in cerebral plasticity and in learning and memory mechanisms, and neuronal death and a loss of brain repair capacity. This has a direct impact on human health, increasing the incidence of chronic and degenerative diseases.
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..Jürgens et al. (17) revealed significant loss of dendritic spines in demyelinated cortex
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2024 Mar 18 Brain volume loss in Japanese patients with multiple sclerosis is present in the early to middle stage of the disease https://pubmed.ncbi.nlm.nih.gov/38545182/
•The first nationwide study to evaluate the association between O3 and CKD in China.
•O3 air pollution was positively associated with odds of CKD prevalence.
•Stronger associations were found in urban regions.
•Stronger associations in young adults and people with high socio-economic status.
Although kidney disease can be associated with MS, few cases have been reported in the literature. The pathogenesis of renal disease in these patients can be related to lower urinary tract dysfunction, recurrent UTI, and treatment with immunomodulatory agents such as interferons. Therefore, neurologists and other physicians managing patients with MS should be aware of the risk of renal disease and monitor patients’ renal function closely during the course of treatment. Further studies are needed to explore renal diseases and their prevention in patients with MS.
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2024 Jun 9
SKL-ESPC & SEPKL-AERM, College of Environmental Sciences and Engineering, and Center for Environment and Health, Peking University, China Glycerophospholipid metabolism changes association with ozone exposure https://pubmed.ncbi.nlm.nih.gov/38876019/
Exposure to ozone (O3) has been associated with cardiovascular outcomes in humans, yet the underlying mechanisms of the adverse effect remain poorly understood. We aimed to investigate the association between O3 exposure and glycerophospholipid metabolism in healthy young adults....
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Changes in lipid metabolism have been suggested to play important roles in MS pathophysiology and progression. In this work we analyzed the lipid composition and sphingolipid-catabolizing enzymes in erythrocytes and plasma from MS patients and healthy controls..
2014 Aug
REVAL Rehabilitation Research Center, BIOMED Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Belgium Does multiple sclerosis affect glucose tolerance? https://pubmed.ncbi.nlm.nih.gov/24347183/