Tropospheric ozone
Re: Tropospheric ozone
O3
2024 Aug 18
Department of Occupational and Environmental Health Sciences, Peking University School of Public Health, Beijing, China
Effects of PM2.5 and O3 sub-chronic combined exposure on ATP amount and ATPase activities in rat nasal mucosa
https://pubmed.ncbi.nlm.nih.gov/39041566/
Conclusion: The ability of power capacity decreased in the rat nasal mucossa under the sub-chronic low-concentration exposure of PM2.5 and O3.
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MS
1998 Apr
Department of Exercise Science, University of Georgia, USA
Muscle fiber type-specific myofibrillar actomyosin Ca2+ ATPase activity in multiple sclerosis
https://pubmed.ncbi.nlm.nih.gov/9533794/
2024 Aug 18
Department of Occupational and Environmental Health Sciences, Peking University School of Public Health, Beijing, China
Effects of PM2.5 and O3 sub-chronic combined exposure on ATP amount and ATPase activities in rat nasal mucosa
https://pubmed.ncbi.nlm.nih.gov/39041566/
Conclusion: The ability of power capacity decreased in the rat nasal mucossa under the sub-chronic low-concentration exposure of PM2.5 and O3.
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MS
1998 Apr
Department of Exercise Science, University of Georgia, USA
Muscle fiber type-specific myofibrillar actomyosin Ca2+ ATPase activity in multiple sclerosis
https://pubmed.ncbi.nlm.nih.gov/9533794/
https://www.eboro.cz
Re: Tropospheric ozone
O3
2024 Jul 19
Maternal Exposure to Ozone and the Risk of Birth Defects: A Time-Stratified Case-Crossover Study in Southwestern China
https://pubmed.ncbi.nlm.nih.gov/39058171/
O3 exposure was associated with an increased risk of birth defects, and the most significant estimates were observed in the first month before pregnancy..
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MS
2010 Nov 16
Congenital Abnormalities and Multiple Sclerosis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020672/
Background
There is a strong maternal parent-of-origin effect in determining susceptibility to multiple sclerosis (MS). One hypothesis is that an abnormal intrauterine milieu leading to impaired fetal development could plausibly also result in increased susceptibility to MS. A possible marker for this intrauterine insult is the presence of a non-fatal congenital anomaly.
Results
The frequency of congential anomalies were compared between index cases and controls. No significant differences were found.
( ? )
2024 Jul 19
Maternal Exposure to Ozone and the Risk of Birth Defects: A Time-Stratified Case-Crossover Study in Southwestern China
https://pubmed.ncbi.nlm.nih.gov/39058171/
O3 exposure was associated with an increased risk of birth defects, and the most significant estimates were observed in the first month before pregnancy..
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MS
2010 Nov 16
Congenital Abnormalities and Multiple Sclerosis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020672/
Background
There is a strong maternal parent-of-origin effect in determining susceptibility to multiple sclerosis (MS). One hypothesis is that an abnormal intrauterine milieu leading to impaired fetal development could plausibly also result in increased susceptibility to MS. A possible marker for this intrauterine insult is the presence of a non-fatal congenital anomaly.
Results
The frequency of congential anomalies were compared between index cases and controls. No significant differences were found.
( ? )
https://www.eboro.cz
Re: Tropospheric ozone
2024 Jul 18Petr75 wrote: ↑Mon Feb 06, 2023 11:04 am 2023 Feb 3
Department of Neuroscience and Rehabilitation, University of Ferrara, Italy
The role of potassium current in the pulmonary response to environmental oxidative stress
https://pubmed.ncbi.nlm.nih.gov/36740034/
Abstract
Exposure of human lung epithelial cells (A549 cell line) to the oxidant pollutant ozone (O3) alters cell membrane currents inducing its decrease, when the cell undergoes to a voltage-clamp protocol ranging from -90 to +70mV. The membrane potential of these cells is mainly maintained by the interplay of potassium and chloride currents. Our previous studies indicated the ability of O3 to activate ORCC and consequently increases the chloride current (Outward Rectifier Chloride Channel). In this paper our aim was to understand the response of potassium current to oxidative stress challenge and to identify the kind potassium channel involved in O3 induced current changes. After measuring the total membrane current using an intracellular solution with or without potassium ions, we obtained the contribution of potassium to the overall membrane current in control condition by a mathematical approach. Repeating these experiments after O3 treatment we observed a significant decrease of Ipotassium. Treatment of the cells with Iberiotoxin (IbTx), a specific inhibitor of BK channel, we were able not only to verify the presence and the functionality of BK channels. In addition, the administration of 4-Aminopyridine (an inhibitor of voltage dependent K channels but not BK channels) and Tetraethylammonium (TEA) before and after O3 treatment we observed the formation of BK oxidative post-translation modifications. Our data suggest that O3 is able to inhibit potassium current by targeting BK channel. Further studies are needed to better clarify the role of this BK channel and its interplay with the other membrane channels under oxidative stress conditions. These findings can contribute to identify the biomolecular pathway induced by O3 allowing a possible pharmacological intervention against oxidative stress damage in lung tissue.
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2014 Mar
4-Aminopyridine for symptomatic treatment of multiple sclerosis: a systematic review
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932769/
School of Pharmacy, University of Wyoming, Laramie, WY, USA
Effect of Voltage-Gated K+ Channel Inhibition by 4-aminopyridine in Spinal Cord Injury Recovery in Zebrafish
https://pubmed.ncbi.nlm.nih.gov/39071260/
Abstract
Spinal cord injury (SCI) affects between 250,000 to 500,000 individuals annually. After the initial injury, a delayed secondary cascade of cellular responses occurs causing progressive degeneration and permanent disability. One part of this secondary process is disturbance of ionic homeostasis. The K+ channel blocker, 4-aminopyridine (4-AP), is used clinically to alleviate symptoms of multiple sclerosis (MS). Several ongoing studies are being conducted to explore additional areas where 4-AP may have an effect, including stroke, traumatic brain injury, and nervous system recovery after SCI. The goal of our study was to determine whether 4-AP affects recovery from SCI in zebrafish (Danio rerio). Using the transgenic line Tg(gfap:EGFP), we created a spinal transection and tracked swim recovery. We found that constant treatment with 10 μM 4-AP increases swimming distance 40%. Live imaging demonstrated that treatment with 4-AP increases radial glial cells bridging at the site of injury in the presence of 4-AP. We conclude that 10 μM 4-AP is pro-regenerative after SCI.
[Free full text]
https://www.eboro.cz
Re: Tropospheric ozone
O3
2023 Mar 16
Risk of ozone exposure-induced fracture
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061083/
Results
The results showed that increased odds of fracture were associated with increased O3 concentrations, presumably because O3 induces oxidative stress (OS) that leads to bone mineral density (BMD) loss.
..In summary, our findings prove that O3 exposure elevates the fracture risk. This study suggests that more attention should be paid to strengthening air pollution control to prevent fracture occurrence. Our findings could also facilitate policy-making decisions toward controlling air pollution as a risk factor for bone health.
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MS
2024 Jul 15
Bone loss and fracture in people with multiple sclerosis: A systematic review and meta-analysis
https://pubmed.ncbi.nlm.nih.gov/39068819/
Conclusion: PwMS were at a substantially increased risk of developing osteopenia (2-fold), osteoporosis (1.7-fold), and overall fractures (1.9-fold). Well-designed studies are needed to explore these associations further.
2023 Mar 16
Risk of ozone exposure-induced fracture
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061083/
Results
The results showed that increased odds of fracture were associated with increased O3 concentrations, presumably because O3 induces oxidative stress (OS) that leads to bone mineral density (BMD) loss.
..In summary, our findings prove that O3 exposure elevates the fracture risk. This study suggests that more attention should be paid to strengthening air pollution control to prevent fracture occurrence. Our findings could also facilitate policy-making decisions toward controlling air pollution as a risk factor for bone health.
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MS
2024 Jul 15
Bone loss and fracture in people with multiple sclerosis: A systematic review and meta-analysis
https://pubmed.ncbi.nlm.nih.gov/39068819/
Conclusion: PwMS were at a substantially increased risk of developing osteopenia (2-fold), osteoporosis (1.7-fold), and overall fractures (1.9-fold). Well-designed studies are needed to explore these associations further.
https://www.eboro.cz
Re: Tropospheric ozone
O3
June 2015 and August 2016
Combined effect of ozone and household air pollution on COPD in people aged less than 50 years old
https://thorax.bmj.com/content/79/1/35
Conclusions This study concludes that exposure to ambient O3 and household air pollution might be important risk factors for COPD among young adults, and simultaneous exposure to high levels of the two pollutants may intensify their individual effects.
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Autoimmune diseases
2024 Sep 30
Autoimmune diseases and COPD risk: A Mendelian randomization study
https://pubmed.ncbi.nlm.nih.gov/39068759/
Conclusion: This research discovered that individuals with type 1 diabetes, hypothyroidism, celiac disease, and systemic lupus erythematosus have a higher likelihood of developing COPD.Additionally, this research revealed no connection between COPD and multiple sclerosis, ulcerative colitis, rheumatoid arthritis, primary biliary cirrhosis, or primary sclerosing cholangitis.
June 2015 and August 2016
Combined effect of ozone and household air pollution on COPD in people aged less than 50 years old
https://thorax.bmj.com/content/79/1/35
Conclusions This study concludes that exposure to ambient O3 and household air pollution might be important risk factors for COPD among young adults, and simultaneous exposure to high levels of the two pollutants may intensify their individual effects.
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Autoimmune diseases
2024 Sep 30
Autoimmune diseases and COPD risk: A Mendelian randomization study
https://pubmed.ncbi.nlm.nih.gov/39068759/
Conclusion: This research discovered that individuals with type 1 diabetes, hypothyroidism, celiac disease, and systemic lupus erythematosus have a higher likelihood of developing COPD.Additionally, this research revealed no connection between COPD and multiple sclerosis, ulcerative colitis, rheumatoid arthritis, primary biliary cirrhosis, or primary sclerosing cholangitis.
https://www.eboro.cz
Re: Tropospheric ozone
O3
July 2022
Ambient ozone exposure combined with residential greenness in relation to serum sex hormone levels in Chinese rural adults
https://www.sciencedirect.com/science/a ... 5122001724
-Given the continuously increasing of surface O3 concentration at the rate of 2–4 μg/m3/yr in China, there is an urgent need to assess the health .. (:/)
- Experiment on animal discovered that mice exposure to O3 had decreased progesterone and testosterone levels because of oxidative stress..
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MS
2024 Jul 29
Association between levels of sex hormones and risk of multiple sclerosis: a mendelian randomization study
https://pubmed.ncbi.nlm.nih.gov/39073697/
Results: The MR analysis, using the IVW method, found a significant correlation between genetically determined SHBG levels and MS (OR = 1.634, 95% CI: 1.029-2.599, p = 0.038)..
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2019 Jan
Impact of sex hormones on immune function and multiple sclerosis development
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283654/
July 2022
Ambient ozone exposure combined with residential greenness in relation to serum sex hormone levels in Chinese rural adults
https://www.sciencedirect.com/science/a ... 5122001724
-Given the continuously increasing of surface O3 concentration at the rate of 2–4 μg/m3/yr in China, there is an urgent need to assess the health .. (:/)
- Experiment on animal discovered that mice exposure to O3 had decreased progesterone and testosterone levels because of oxidative stress..
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MS
2024 Jul 29
Association between levels of sex hormones and risk of multiple sclerosis: a mendelian randomization study
https://pubmed.ncbi.nlm.nih.gov/39073697/
Results: The MR analysis, using the IVW method, found a significant correlation between genetically determined SHBG levels and MS (OR = 1.634, 95% CI: 1.029-2.599, p = 0.038)..
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2019 Jan
Impact of sex hormones on immune function and multiple sclerosis development
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283654/
https://www.eboro.cz
Re: Tropospheric ozone
O3
2024 Jan-Dec
The effects of short-time air pollution, SO2, and ozone on biochemical, histo-pathological, oxidative stress, and carcinogenesis related genes expressions in the liver of the rats
https://pubmed.ncbi.nlm.nih.gov/39073095/
Conclusions: The findings revealed an alteration in liver histopathology, an induction of oxidative stress, and the expression of some apoptosis-related genes in hepatic tissues after exposure to AAP, SO2, and O3.
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MS
October 9, 2006
Liver test abnormalities in multiple sclerosis: Findings from placebo-treated patients
https://www.neurology.org/doi/abs/10.12 ... 5.27055.62
Abstract
The risk of an abnormal liver test in 813 patients with multiple sclerosis or clinically isolated syndrome enrolled in placebo arms of clinical trials was greater than expected for alanine aminotransferase (ALT) (relative risk [RR] 3.7; 95% CI: 2.3 to 6.0) and aspartate aminotransferase (AST) (RR 2.2; 95% CI: 1.3 to 3.6), although not alkaline phosphatase (AP) or total bilirubin, at first presentation. Abnormal test results were associated with higher body mass index (ALT only), male gender (ALT only), and a relapsing-remitting (vs secondary-progressive) course (ALT and AST only).
2024 Jan-Dec
The effects of short-time air pollution, SO2, and ozone on biochemical, histo-pathological, oxidative stress, and carcinogenesis related genes expressions in the liver of the rats
https://pubmed.ncbi.nlm.nih.gov/39073095/
Conclusions: The findings revealed an alteration in liver histopathology, an induction of oxidative stress, and the expression of some apoptosis-related genes in hepatic tissues after exposure to AAP, SO2, and O3.
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MS
October 9, 2006
Liver test abnormalities in multiple sclerosis: Findings from placebo-treated patients
https://www.neurology.org/doi/abs/10.12 ... 5.27055.62
Abstract
The risk of an abnormal liver test in 813 patients with multiple sclerosis or clinically isolated syndrome enrolled in placebo arms of clinical trials was greater than expected for alanine aminotransferase (ALT) (relative risk [RR] 3.7; 95% CI: 2.3 to 6.0) and aspartate aminotransferase (AST) (RR 2.2; 95% CI: 1.3 to 3.6), although not alkaline phosphatase (AP) or total bilirubin, at first presentation. Abnormal test results were associated with higher body mass index (ALT only), male gender (ALT only), and a relapsing-remitting (vs secondary-progressive) course (ALT and AST only).
https://www.eboro.cz
Re: Tropospheric ozone
2024 Aug 1
Neuroscience Graduate Program, University of Southern California, Los Angeles, CA, USA
Exposure to multiple ambient air pollutants changes white matter microstructure during early adolescence with sex-specific differences
https://pubmed.ncbi.nlm.nih.gov/39090375/
Background: Air pollution is ubiquitous, yet questions remain regarding its impact on the developing brain. Large changes occur in white matter microstructure across adolescence, with notable differences by sex..
Results: Here we show higher PM2.5 exposure is associated with higher RND at age 9 in both sexes, with no significant effects of PM2.5 on RNI/RND change over time. Higher NO2 exposure is associated with higher RNI at age 9 in both sexes, as well as attenuating RNI over time in females. Higher O3 exposure is associated with differences in RND and RNI at age 9, as well as changes in RND and RNI over time in both sexes.
Neuroscience Graduate Program, University of Southern California, Los Angeles, CA, USA
Exposure to multiple ambient air pollutants changes white matter microstructure during early adolescence with sex-specific differences
https://pubmed.ncbi.nlm.nih.gov/39090375/
Background: Air pollution is ubiquitous, yet questions remain regarding its impact on the developing brain. Large changes occur in white matter microstructure across adolescence, with notable differences by sex..
Results: Here we show higher PM2.5 exposure is associated with higher RND at age 9 in both sexes, with no significant effects of PM2.5 on RNI/RND change over time. Higher NO2 exposure is associated with higher RNI at age 9 in both sexes, as well as attenuating RNI over time in females. Higher O3 exposure is associated with differences in RND and RNI at age 9, as well as changes in RND and RNI over time in both sexes.
https://www.eboro.cz
Re: Tropospheric ozone
2024 Nov 1
Impact of formaldehyde on ozone formation in Central China: Important role of biogenic emission in forest region
https://pubmed.ncbi.nlm.nih.gov/39089373/
Formaldehyde (HCHO) is an important source for driving tropospheric ozone (O3) formation..
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2021 Jun 1
Formaldehyde and Brain Disorders: A Meta-Analysis and Bioinformatics Approach
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102312/
Impact of formaldehyde on ozone formation in Central China: Important role of biogenic emission in forest region
https://pubmed.ncbi.nlm.nih.gov/39089373/
Formaldehyde (HCHO) is an important source for driving tropospheric ozone (O3) formation..
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2021 Jun 1
Formaldehyde and Brain Disorders: A Meta-Analysis and Bioinformatics Approach
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102312/
https://www.eboro.cz
Re: Tropospheric ozone
O3
2024 Oct 9
State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, China
Differences in cellular and molecular processes in exposure to PM2.5 and O3
https://pubmed.ncbi.nlm.nih.gov/39406161/
...Our findings indicate that PM2.5 infiltrates cells via endocytosis without causing significant damage to cell membranes, while O3 induces lipid peroxidation at the cell surface...
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MS
15 December 2011
Journal of the Neurological Sciences
Peroxidation of lipoproteins in multiple sclerosis
https://www.sciencedirect.com/science/a ... 0X11005491
..Several studies have demonstrated a significant increase in lipid peroxidation products in brain, plasma and cerebrospinal fluid of MS patients
2024 Oct 9
State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, China
Differences in cellular and molecular processes in exposure to PM2.5 and O3
https://pubmed.ncbi.nlm.nih.gov/39406161/
...Our findings indicate that PM2.5 infiltrates cells via endocytosis without causing significant damage to cell membranes, while O3 induces lipid peroxidation at the cell surface...
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MS
15 December 2011
Journal of the Neurological Sciences
Peroxidation of lipoproteins in multiple sclerosis
https://www.sciencedirect.com/science/a ... 0X11005491
..Several studies have demonstrated a significant increase in lipid peroxidation products in brain, plasma and cerebrospinal fluid of MS patients
https://www.eboro.cz
Re: Tropospheric ozone
O3
December 2016
Associations among plasma metabolite levels and short-term exposure to PM2.5 and ozone in a cardiac catheterization cohort
https://www.sciencedirect.com/science/a ... 2016305864
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MS
2024 Nov 7
Causal association between plasma metabolites and diverse autoimmune diseases(ADs): a two-sample bidirectional mendelian randomization study
https://pubmed.ncbi.nlm.nih.gov/39575250/
Conclusions: Our research established a reciprocal causality between plasma metabolites and ADs. Furthermore, diverse metabolic pathways correlated with ADs were uncovered. Novel insights into the prediction and diagnosis were provided, as well as new targets for precise treatment of these conditions were discovered.
December 2016
Associations among plasma metabolite levels and short-term exposure to PM2.5 and ozone in a cardiac catheterization cohort
https://www.sciencedirect.com/science/a ... 2016305864
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MS
2024 Nov 7
Causal association between plasma metabolites and diverse autoimmune diseases(ADs): a two-sample bidirectional mendelian randomization study
https://pubmed.ncbi.nlm.nih.gov/39575250/
Conclusions: Our research established a reciprocal causality between plasma metabolites and ADs. Furthermore, diverse metabolic pathways correlated with ADs were uncovered. Novel insights into the prediction and diagnosis were provided, as well as new targets for precise treatment of these conditions were discovered.
https://www.eboro.cz
Re: Tropospheric ozone
2024 Nov 10Petr75 wrote: ↑Mon Apr 02, 2018 3:59 am MS
21 May 2010
Anna Maria Malagoni, Paolo Zamboni and Roberto ManfrediniEmail author, BMC Neurology
A seasonal periodicity in relapses of multiple sclerosis? A single-center, population-based, preliminary study conducted in Bologna, Italy
https://bmcneurol.biomedcentral.com/art ... 377-10-105
.. Conclusions:
In this Italian setting, we found a biphasic pattern (peaks in spring and autumn) in severe MS relapses requiring medical consultation by doctors of the MS specialty center, apparently unrelated to meteorological variables..
Observational study of gadolinium-enhancing lesions in MRI in patients with multiple sclerosis from the Spanish Mediterranean coast: Seasonal variability and relationship with climatic factors
https://pubmed.ncbi.nlm.nih.gov/39571217/
Conclusion: These findings suggest a non-uniform monthly distribution of gadolinium-enhancing lesions and an association between warmer nights and increased MRI activity, pointing to a potential impact of environmental factors on multiple sclerosis activity in neuroimaging.
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March 2019
Seasonal variation in surface ozone and its regional characteristics at global atmosphere watch stations in China
https://www.sciencedirect.com/science/a ... 4218308842
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Surface Ozone
Starting date: 1-1-1996
https://cimone.isac.cnr.it/node/89
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CZ
https://www.eboro.cz