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jimmylegs wrote: ↑Fri Nov 18, 2022 5:14 am found these, 400mg/d would be a good daily amount - esp if you've been in decline for years and years. looks like giving it a try for a week would cost even less than a test, and just be good for you either way: https://www.burmanshealthshop.com/produ ... glycinate/

The caplets I take are 100mg Mg each. They’re fairly large. Do you know the dosage/tablet for the Burman’s tablets? That info is absent from that site. If they were actually 400mg each, then they would be huge! I would be wary about buying supplements from a site without full disclosure of the supplement’s ingredients.

it came up bc i put pennsylvania in the search terms. the product photo could be better. there's help chat on the site i notice, and the shop gets rave reviews by the looks of things. potentially a moot pt anyway!

Neurologist just prescribed me Duloxetine (Cymbalta)

Hi,

So here's a simple description of why it is used. Does this sound like you?
https://en.wikipedia.org/wiki/Duloxetine

Regards,

Scott1 wrote: ↑Fri Nov 18, 2022 4:44 pm Hi,

So here's a simple description of why it is used. Does this sound like you?
https://en.wikipedia.org/wiki/Duloxetine

Regards,

Well....for the neuropathic pains, yes.

Hi,

Have a good read of this

https://www.drugs.com/monograph/duloxetine.html

When do you see the rheumatologist?

Regards,

DudeFromPA wrote: ↑Fri Nov 18, 2022 5:12 pm

Scott1 wrote: ↑Fri Nov 18, 2022 4:44 pm Hi,

So here's a simple description of why it is used. Does this sound like you?
https://en.wikipedia.org/wiki/Duloxetine

Regards,

Well....for the neuropathic pains, yes.

From the above link...

“Common side effects include dry mouth, nausea, feeling tired, dizziness, agitation, sexual problems, and increased sweating.”

The role of magnesium in pain
https://www.ncbi.nlm.nih.gov/books/NBK507245/
" The beneficial effects of magnesium treatment have also been demonstrated in patients suffering from neuropathic pain..."

How can proton pump inhibitors damage central and peripheral nervous systems?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716020/
"PPI use has been reported to be associated with neuropathies ... Magnesium plays a major role in CNS functioning ... When deficient it can cause ... neuronal dysfunction and death due to overactivation (Vink and Nechifor, 2011). Magnesium also exhibits neuroprotective effects through regulation of oxidative stress ... There is an association of magnesium deficiency with ... neurogenic inflammation (Vink and Nechifor, 2011)."

Proton Pump Inhibitor (PPI) Lawsuits
https://www.drugwatch.com/proton-pump-i ... /lawsuits/
"As of October 2022, there were 13,350 proton pump inhibitor lawsuits pending in federal court ... "

i noticed that these are often over the counter items, but now i am also seeing issues not just with omeprazole, but also with ranitidine. this is looking like a candidate alternative to both:
https://www.zantacotc.com/en-us/where-t ... antac-360/

NHE wrote: ↑Sat Nov 19, 2022 12:39 am

DudeFromPA wrote: ↑Fri Nov 18, 2022 5:12 pm

Scott1 wrote: ↑Fri Nov 18, 2022 4:44 pm Hi,

So here's a simple description of why it is used. Does this sound like you?
https://en.wikipedia.org/wiki/Duloxetine

Regards,

Well....for the neuropathic pains, yes.

From the above link...

“Common side effects include dry mouth, nausea, feeling tired, dizziness, agitation, sexual problems, and increased sweating.”

Yeah, I'm screwed with that I guess. Excessive sweating is a symptom of Omeprazole, testosterone therapy, and this new med....so doomed there I guess. No way of knowing which one is causing it or all three now.

jimmylegs wrote: ↑Sat Nov 19, 2022 4:17 am The role of magnesium in pain
https://www.ncbi.nlm.nih.gov/books/NBK507245/
" The beneficial effects of magnesium treatment have also been demonstrated in patients suffering from neuropathic pain..."

How can proton pump inhibitors damage central and peripheral nervous systems?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716020/
"PPI use has been reported to be associated with neuropathies ... Magnesium plays a major role in CNS functioning ... When deficient it can cause ... neuronal dysfunction and death due to overactivation (Vink and Nechifor, 2011). Magnesium also exhibits neuroprotective effects through regulation of oxidative stress ... There is an association of magnesium deficiency with ... neurogenic inflammation (Vink and Nechifor, 2011)."

Proton Pump Inhibitor (PPI) Lawsuits
https://www.drugwatch.com/proton-pump-i ... /lawsuits/
"As of October 2022, there were 13,350 proton pump inhibitor lawsuits pending in federal court ... "

i noticed that these are often over the counter items, but now i am also seeing issues not just with omeprazole, but also with ranitidine. this is looking like a candidate alternative to both:
https://www.zantacotc.com/en-us/where-t ... antac-360/

Yeah, I've read about this too. But darned if I do, darned if I don't. No way around PPI's for me with my ridiculous reflux condition.

What's killing me more than anything though lately is the chronic constipation. Been dealing with this now actually going on 2 years but the past several months it's been in overdrive. Nothing I do or take helps except a handful of laxatives to force clear myself out every other week.

If I don't stay on top of that, I get these terribly painful attacks of stomach and intestinal pain and severe bloating.

Not even regular stool softeners works. Yes, I drink plenty of water. It has to be straight laxatives. I can't eat fiber rich foods like many vegetables because they set my IBS and pain through the roof. Most veggies today are my cryptonite. I probably should get on a steady diet of fiber supplements but I'm concerned how my gut will react to those too.

On the waiting list to see a gastroenterologist now too. Never ending parade of medical appointments these days.

The following post may be of interest to you. Richard Miller recovered from 20 years of chronic illness by changing his diet.

viewtopic.php?p=257206#p257206

ok this is going to sound ridiculous but here goes: I have to strongly recommend magnesium as a laxative!

so, since you definitely need something for reflux, please consider zantac 360 which doesn't have the mineral depletion, sweating, or kidney damage reported for omeprazole.
https://www.rxlist.com/zantac-360-drug.htm#description

to help fight cramp/charlie horse, neuropathic pain, constipation, and more; also to replace likely chronically depleted tissue stores of magnesium, please consider supplemental magnesium alongside zantac 360.

personally, to strike the right balance i have to combine a soluble, absorbable form like magnesium glycinate with a more laxative form like plain magnesium oxide.

with the right blend of supplemental magnesium, i would expect you to find a balance that works for you.

'pro' tip: stay close to a toilet as you test daily increases in supplemental mag!