This Is MS Multiple Sclerosis Knowledge & Support Community

Once again EBV is the trigger!

https://www.iflscience.com/virus-likely ... udes-62236

Thanks to you DIM I started taking FEVERFEW herb to control the EBV. I think my current problem is more structural than viral, but hope for the best.
Regards, Vesta

Unfortunately bioavailability of Feverfew is minimal and there aren't supplements in lipophilic form, I do give it to my wife but I am going to start her Valacyclovir treatment, hope it will work!

MS activity reactivates dormant Epstein-Barr virus study finds!

https://ms-uk.org/news/ms-activity-reac ... udy-finds/

The initial and free publication of this study:

https://pmc.ncbi.nlm.nih.gov/articles/PMC9915775/

Editor’s summary
Epstein-Barr virus (EBV) infection predisposes individuals to multiple sclerosis (MS). Adaptive immune responses to EBV occur in deep cervical lymph nodes (dcLNs), yet the immune landscape in dcLN from patients with MS (pwMS) is not well understood. Sarkkinen et al. profiled immune cells from dcLNs of pwMS using fine-needle aspirations. By combining single-cell RNA sequencing and cellular indexing of transcriptomes and epitopes by sequencing, they identify expansion of double-negative memory B cells enriched for a transcriptional profile that resembled a lytic EBV infection. Furthermore, fewer germinal center (GC) B cells and GC T follicular helper cells were detected in pwMS, and GC clonality was reduced. These findings provide insight into MS pathogenesis at the site of adaptive immune response to EBV.


https://www.science.org/doi/10.1126/sciimmunol.adl3604

2025 Feb 21
Translational Immunology Research Program, University of Helsinki, Helsinki, Finland
Altered immune landscape of cervical lymph nodes reveals Epstein-Barr virus signature in multiple sclerosis
https://pubmed.ncbi.nlm.nih.gov/39982975/

Professor Gavin Giovannoni about ACTRIMS 2025, EBV and Tolebrutinib (BTK inhibitor):


https://gavingiovannoni.substack.com/p/ ... open=false

Epstein-Barr virus may drive MS by dysregulating certain immune cells
Cells in neck lymph nodes show abnormal activity, reactions against EBV: Study

https://multiplesclerosisnewstoday.com/ ... une-cells/

Hi,

These people like Giovannoni are trapped in the web they created themselves.
They have created a thinking of enormous complexity overlooking some basic factors.
And often their work considers biological issues after the event.

Of course EBV is a trigger of MS. But not the only condition.
98% of the population carries EBV, 2% is negative on EBV.
Among the people who are seronegative, there is virtually zero MS.
If you do the sums, this is proof that EBV is a factor that triggers MS.

The other important factor is cellular immunity.
Cellular immunity is key to keep herpes viridae in check.
I am not here to promote my own thinking but I do believe it comes much closer to what MS really is.
See this document about the herpes cycle viewtopic.php?p=264434#p264434

Regards,

Covid vaccination may reactivate EBV:

https://news.yale.edu/2025/02/19/immune ... directions

Proffesor Giovannoni update on treatments for MS-EBV (downloadable pdf):

https://www.isrctn.com/pdf/69709064

For sure, EBV is a factor. It may cause chromosome breaks in the cristae of the mitochondria.
But EBV is not necessarily the only factor.
The average mid-aged person is infected by 4.4 herpes viral strains.
In my case, I carried also VZV, the Zoster strain.
That herpes strain is known for its micro vascular bleedings. Opens the BBB.
It will often be a combination of herpes viridae.

Leonard wrote: ↑Wed May 14, 2025 2:06 am For sure, EBV is a factor. It may cause chromosome breaks in the cristae of the mitochondria.
But EBV is not necessarily the only factor.
The average mid-aged person is infected by 4.4 herpes viral strains.
In my case, I carried also VZV, the Zoster strain.
That herpes strain is known for its micro vascular bleedings. Opens the BBB.
It will often be a combination of herpes viridae.

Of course, like HHV 6a and CMV, on the other hand Valacyclovir is effective against all of them!