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Conclusions: O3 exposure may reduce oxygen availability, prompting compensatory increases in red blood cells and hemoglobin, which exacerbate arterial stiffening. These findings provide new insights into the mechanisms underlying O3-induced cardiovascular injury.
... Hypoxia has been associated with multiple sclerosis (MS) for years.1 Type III lesions in MS brain are histologically similar to hypoxic/ischemic lesions, and lesions tend to form in areas that are more susceptible to hypoxia
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January 3, 2025 Meta-Analysis: Vascular Function Worse in People With MS https://www.ajmc.com/view/meta-analysis ... le-with-ms
..A significant difference in arterial stiffness was found (SMD 0.78; 95% CI, 0.21, 1.36; P = .008), but there were no significant differences in arterial structure or function outcomes, the investigators noted. “These findings may suggest pathophysiological changes in MS may particularly impact arterial stiffness more than other aspects of vascular health,” they wrote.
Abstract
The ability of urban oxidant and acid air pollutants to induce heat shock proteins (HSPs) in the mammalian lung is not known. Such proteins are known to be correlated with environmental stress and pathophysiological conditions...
Abstract
Genetic factors are effective reagents in susceptibility to multiple sclerosis (MS). Previous studies have shown the relationship between heat shock protein (HSP) gene polymorphisms...
Re: Tropospheric ozone
Posted: Tue Feb 04, 2025 11:36 am
by Petr75
O3
June 2020 Ozone increases plasma kynurenine-tryptophan ratio and impacts hippocampal serotonin receptor and neurotrophic factor expression: Role of stress hormones https://www.sciencedirect.com/science/a ... 5120303765
• Ozone inhalation increased the plasma kynurenine/tryptophan ratio.
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MS
2025 Mar Dysregulation of the Kynurenine Pathway in Relapsing Remitting Multiple Sclerosis and Its Correlations With Progressive Neurodegeneration https://pubmed.ncbi.nlm.nih.gov/39823555/
Discussion: These findings highlight changes in the biosynthesis of KP during the progression of RRMS and its correlation with axonal loss. This study underscores the potential of targeting the KP in developing novel treatments for neuroaxonal damage in MS and warrants future research in greater depth.
Re: Tropospheric ozone
Posted: Thu Feb 06, 2025 11:36 am
by Petr75
Re: Tropospheric ozone
Posted: Thu Feb 06, 2025 11:37 am
by Petr75
O3
2025 Jan 18
Metabolomic profiling reveals systemic metabolic disruptions induced by combined exposure to particulate matter and ozone https://pubmed.ncbi.nlm.nih.gov/39911777/
Abstract
Air pollution exposure, especially particulate matter (PM) and ozone (O3), poses significant health risks, but the systemic metabolic consequences of combined exposures to PM and O3, remain poorly understood. This study investigated systemic metabolic changes in male spontaneously hypertensive (SH) rats following inhalation exposure to concentrated ambient particles (CAPs) (PM2.5, 150 μg/m3), ozone (O3) (0.2 ppm), and their combination. Rats were exposed for 4 h, and serum samples were collected 1-hour post-exposure. Using targeted metabolomics, we identified significant alterations in metabolites involved in lipid metabolism (phosphatidylcholines), energy metabolism (acylcarnitine C3), and oxidative stress (glutamine). Notably, the combination exposure induced distinct metabolic changes, including increased acylcarnitine C3 levels, suggesting heightened mitochondrial dysfunction. Principal component analysis revealed overlapping profiles between CAPs and controls, indicating a subtler impact of CAPs compared to ozone or combined exposure. These systemic metabolic alterations are aligned with our previously published proteomics findings in cardiac tissues from the same rats, which showed elevated inflammatory markers (e.g., IL-6, TNF-α) and mitochondrial dysfunction. In conclusion, this study provides new insights into the systemic metabolic effects of air pollutant exposure, identifies novel metabolic targets of pollutant-induced toxicity, highlights the complex interactions resulting from combined exposure to multiple pollutants, and underscores the importance of assessing the combined effects of multiple pollutants in air pollution risk assessments.
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2025 Feb 4 dilp2-Mediated Insulin Signaling Pathway Was Involved in O3-Induced Multigenerational Effects of Shortened Lifespan in Drosophila melanogasters https://pubmed.ncbi.nlm.nih.gov/39903660/
..Transcriptome analysis unveiled significant disruptions in metabolic pathways, notably the insulin signaling pathway..
Re: Tropospheric ozone
Posted: Fri Feb 14, 2025 12:12 pm
by Petr75
O3
2025 Feb 13 Identifying the spatiotemporal patterns and natural and socioeconomic influencing factors of PM2.5 and O3 pollution in China https://pubmed.ncbi.nlm.nih.gov/39946421/
..The results show that PM2.5 and O3 concentrations exhibit distinct monthly U-shaped and inverted U-shaped temporal fluctuation patterns across Chinese cities, respectively. ..
Conclusions: The prevalence of MS in Telemark is among the highest ever reported in Norway, consistent with an increasing incidence in the county over the past twenty years. The even higher prevalence in the rural areas is unlikely to be explained by possible risk factors like latitude, exposure to sunlight and diet. Further studies on differences between urban and rural areas are required to reveal possible new risk factors.
Re: Tropospheric ozone
Posted: Tue Feb 18, 2025 11:53 am
by Petr75
2025 Jan 31 Novel Triple-Oxygen Isotope Study Indicates Unprecedented Ozone-Particulate Interaction Pathways in Atmospheric Pollution Chemistry https://pubmed.ncbi.nlm.nih.gov/39959052/
2025 Jan 27 Associations between IL-6 and trajectories of depressive symptoms across the life course: Evidence from ALSPAC and UK Biobank cohorts https://pubmed.ncbi.nlm.nih.gov/39865800/
Conclusions: These findings suggest that systemic inflammation may influence the severity and course of depressive symptoms across the life course, which is apparent regardless of age and differences in measures and number of time points between these large, population-based cohorts.
2024 Jun 14 Migraine Risk in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder: A Nationwide Cohort Study in South Korea https://pubmed.ncbi.nlm.nih.gov/38880093/
Conclusion: The study results revealed an increased risk of migraines in patients with MS but not in patients with NMSOD compared with matched controls.
Conclusion: Migraine was associated with an increased odds of MS only when co-occurrence was considered. These findings imply that migraines are part of the constellation of MS onset symptoms rather than a risk factor for or prodromal symptom of MS.
Re: Tropospheric ozone
Posted: Thu Feb 20, 2025 10:31 am
by Petr75
2024 Dec 30 Fine Scale Spatial and Temporal Allocation of NOx Emissions from Unconventional Oil and Gas Development Can Result in Increased Predicted Regional Ozone Formation https://pubmed.ncbi.nlm.nih.gov/39975534/
Re: Tropospheric ozone
Posted: Fri Feb 21, 2025 12:22 pm
by Petr75
Re: Tropospheric ozone
Posted: Sat Feb 22, 2025 9:15 am
by Petr75
O3
2025 Feb 18 Short-Term Associations Between Ambient Ozone and Acute Myocardial Infarction Onset Among Younger Patients: Results From the VIRGO Study https://pubmed.ncbi.nlm.nih.gov/39968338/
•The overall prevalence of MI was 1.7% among MS patients.
•The pooled odds ratio estimate for MI was 1.4, indicating that MS increased the odds of MI by 41%.
Re: Tropospheric ozone
Posted: Sat Feb 22, 2025 9:18 am
by Petr75
2025 Feb 18 Revealing the nonlinear responses of PM2.5 and O3 to VOC and NOx emissions from various sources in Shandong, China https://pubmed.ncbi.nlm.nih.gov/39983648/
..The results showed that O3 could significantly promote the degradation, nitration and oligomerization of BSA, indicating that O3 is the primary driver of the multiphase reactions.