CCSVI and CCVBP

[uprightdoc]

http://www.biomedsearch.com/attachments ... 54-5-7.pdf


Heavy reading! It would be good if this thought had been expanded to problems when the outflows of the brain, veins are malformed.

Hope you're having as nicer weather as we are, very hot, no wind and its the weekend.
Regards Nigel

Edited. After thought, the skull size and design differences between male and female correlate with the prevalence of MS. Interesting!!!!!!!!!

Nigel,

Here are a few pearls from the above paper on CSF researh regarding hydrocephalus and Chiari malformations:

Hydrocephalus progresses because of venous insufficiency...hindbrain herniation (Chiari malformation) is caused by abnormal craniocervical (venous and CSF) pressure gradient...Chiari malformations damage(s) neural tissue by ischemic (decreased arterial blood flow) and mechanical forces .. Veins situated inbetween the dura and surrounding bone are highly compressible and capable of large volume fluctuations. Such veins are prominent in the spine (vertebral venous plexus) ... The potential range in pressure is arguably greatest in the spine because of the capacity and compressibility of the intraspinal venous plexus vessels ... It is proposed that hydrocephalus is an edema (poor drainage) of the central nervous system. Rapidly developing venous insufficiency leads to an increase in parenchyma (brain tissue) water content ... vertebral deformity ... may reduce space and CSF flow ... Vertebral injury causing abnormal function of the spinal venous plexus may impair spinal venous drainage ...

In this regard, you have veretebral deformities that affect shape and dimensions of the the spinal canal. They also press on the thecal sac of the cord which contains the vertebral veins. The vertebral veins are small so that small increases in pressure on the thecal sac have a large impact on the veins, which can further affect arterial blood flow resulting in chronic ischemia. Ischemia is on of the chief suspects in nerve and myelin degeneration.

[NZer1]

As the article has sat with me mentally, I have been pondering how this can be shown by MR or other technology. Most of the work that is coming to the surface from past research has been held back by technology to support the expansion of the knowledge.
Did you talk with Dr. Haacke about help with expanding knowledge by the supporting imaging?
The question that remains for me is how to show the link between damage and outcome. In my example of neck injury through sport and later life onset of MS would be a challenge to image the process of degeneration.
The example of the Lady in your book where there is rapid onset of disability would make the case easier to work on from an in depth imaging sequence. The example of people with RRMS having episodic exacerbations would also be another example if the technology could find the area of 'damage' causing the disability. The progressives are so much harder to disassemble the process of degeneration and find an initial point of the cascade.
The connection to stroke processes and MS interests me from the perspective that the stroke disability onset and in some cases the continuance of disability is very similar. The clot aspect of stroke and the blood starvation or back flow in MS is a similar damaging process.
I intend to read more about the glutamate cascade, something about this has got my attention as well.
The quotes that you put in your last comment have me yet again wondering why this information has not been linked to MS and other diseases. So many things have been avoided for what ever reason and the chemical and drug induced approach to regaining health has taken scientists attention.
Good to see Dr Zamboni is looking for a broader understanding of flows.

[NZer1]

Chronic mild cerebrovascular dysfunction as a cause for Alzheimer's disease?
Abstract
Alzheimer's disease (AD) is a progressive chronic disorder and is characterized by β-amyloid plaques and angiopathy, tau pathology, neuronal cell death, and inflammatory responses. The reasons for this disease are not known. This review proposes the hypothesis that a chronic mild longlasting cerebrovascular dysfunction could initiate a cascade of events leading to AD. It is suggested that (vascular) risk factors (e.g. hypercholesterolemia, type 2 diabetes, hyperhomocysteinemaia) causes either damage of the cerebrovascular system including silent strokes or causes dysregulation of beta-amyloid clearance at the blood-brain barrier resulting in increased brain beta-amyloid. A cascade of subsequent downstream events may lead to disturbed metabolic changes, and neuroinflammation and tau pathology. The role of NGF on the cell death of cholinergic neurons is discussed. Additional risk factors (e.g. acidosis, metals) contribute to plaque development.
[url=http://www.sciencedirect.com/science?
_ob=ArticleURL&_udi=B6T6J-51JPWS0-2&_user=10&_cover
Date=11/26/2010&_rdoc=1&_fmt=high&_orig=search&_origin
=search&_sort=d&_docanchor&view=c&_acct=C000050221&_version
=1&_urlVersion=0&_userid=10&md5=e3c90ff80f0c0fcd9dc9bbefbcd86388&searchtype=a]Link[/url]

[NZer1]

Hi Dr. Have you seen;
Chronic mild cerebrovascular dysfunction
as a cause for Alzheimer’s disease?
Christian Humpel
It appeared on another site,
http://www.facebook.com/pages/CCSVI-at- ... 2832983940
I will read it after I recover this afternoon, it is a PDF so I would have to email it, send me a PM if you want a copy.

[NZer1]

Have you seen this post folks, sound familiar?

POTS and CCSVI
http://www.thisisms.com/ftopict-14766.html
I have been wondering about connection between Postural orthostatic tachycardia syndrome and CCSVI. There seems to be so much common in these two conditions.

[HappyPoet]

Hi Dr. Flanagan,

I hope you've been doing well. I continue with my AO checks/adjustments and am extremely happy with my improvements!

You might be interested in this new thread, first annual ISNVD meeting in March 2011, which has a couple posts about NPH.

~HP

[uprightdoc]

Have you seen this post folks, sound familiar?

POTS and CCSVI
http://www.thisisms.com/ftopict-14766.html
I have been wondering about connection between Postural orthostatic tachycardia syndrome and CCSVI. There seems to be so much common in these two conditions.

Below is a link to an eye doctor's blog. The doctor has EDS. Many EDS patients get POTS and MS as well. EDS is often associated with design problems in the skull, called craniosynostosis, such as an undersized posterior fossa. They also tend to have hypermobility of the joints, including the upper cervical spine.

http://theeyedocblog.com/

[uprightdoc]

Hi Dr. Flanagan,

I hope you've been doing well. I continue with my AO checks/adjustments and am extremely happy with my improvements!

You might be interested in this new thread, first annual ISNVD meeting in March 2011, which has a couple posts about NPH.
~HP

Hello Poet,
I am happy to hear you are doing well.
I will not be going to Rome but Dr. Woodfield is. It's interesting that ISNVD will be investigating the connection to NPH and benign intracranial hypertension (BIH) also known as pseudo tumor cerebri. I first wrote about the connection between venous drainage problems in the brain and CSF flow and intracranial pressure in 1987. At the time I was looking into the role of NPH in Alzheimer's and Parkinson's disease. I just included a link in my last response to Nigel regarding EDS-POTS-MS. Many of these cases have BIH due to sluggish CSF flow. BIH can compress the brainstem similar to a Chiari malformation.

[HappyPoet]

Hi Dr. Flanagan,

I hope you've been doing well. I continue with my AO checks/adjustments and am extremely happy with my improvements!

You might be interested in this new thread, first annual ISNVD meeting in March 2011, which has a couple posts about NPH.
~HP

Hello Poet,
I am happy to hear you are doing well.
I will not be going to Rome but Dr. Woodfield is. It's interesting that ISNVD will be investigating the connection to NPH and benign intracranial hypertension (BIH) also known as pseudo tumor cerebri. I first wrote about the connection between venous drainage problems in the brain and CSF flow and intracranial pressure in 1987. At the time I was looking into the role of NPH in Alzheimer's and Parkinson's disease. I just included a link in my last respone to Nigel regarding EDS-POTS-MS. Many of these cases have BIH due to sluggish CSF flow. BIH can compress the brainstem similar to a Chiari malformation.

I have a wonderful feeling that we're at the dawn of a new understanding of the true causes of many neurological symptoms, conditions, syndromes, and diseases with all the sciences converging toward a consensus that will help millions of people all over the world.

[blossom]

it is great hearing our happypoet is now an "extremely happypoet"!!!

[NZer1]

I was sent this via a friend in NZ
https://www.jvsr.com/abstracts/index.asp?id=205
Original Research
Eighty-One Patients with Multiple Sclerosis and Parkinson’s Disease Undergoing Upper Cervical Chiropractic Care to Correct Vertebral Subluxation: A Retrospective Analysis
Erin L. Elster, D.C. Bio
[August 2, 2004, pp 1-9]
Objective: The objective of this article is threefold: to examine the role of head and neck trauma as a contributing factor to the onset of Multiple Sclerosis (MS) and Parkinson’s disease (PD); to explore the diagnosis and treatment of trauma-induced injury to the upper cervical spine through the use of protocol developed by the International Upper Cervical Chiropractic Association (IUCCA); and to investigate the potential for improving and arresting MS and PD through the correction of traumainduced upper cervical injury. Data from 81 MS and PD patients who recalled prior trauma, presented with upper cervical injuries, and received care according to the above protocol are
reviewed.

Clinical Features: Each patient was examined and cared for in the author’s private practice in an uncontrolled, non-randomized environment over a five-year period. Of the 81 MS and PD patients, 78 recalled that they had experienced at least one head or neck trauma prior to the onset of the disease. In order of frequency, patients reported that they were involved in auto accidents (39 patients); sporting accidents, such as skiing, horseback riding, cycling, and football (29 patients); or falls on icy sidewalks or down stairs (16 patients). The duration between the traumatic event and disease onset varied from two months to 30 years.

Intervention and Outcome: Two diagnostic tests, paraspinal digital infrared imaging and laser-aligned radiography, were performed according to IUCCA protocol. These tests objectively identify trauma-induced upper cervical subluxations (misalignment of the upper cervical spine from the neural canal) and resulting neuropathophysiology. Upper cervical subluxations were found in all 81 cases. After administering treatment to correct their upper cervical injuries, 40 of 44 (91%) MS cases and 34 of 37 (92%) PD cases showed symptomatic improvement and no further disease progression during the care period.

Conclusion: A causal link between trauma-induced upper cervical injury and disease onset for both MS and PD appears to exist. Correcting the injury to the upper cervical spine through the use of IUCCA protocol may arrest and reverse the progression of both MS and PD. Further study in a controlled, experimental environment with a larger sample size is recommended.

[MS_HOPE]

I was sent this via a friend in NZ
https://www.jvsr.com/abstracts/index.asp?id=205
Original Research
Eighty-One Patients with Multiple Sclerosis and Parkinson’s Disease Undergoing Upper Cervical Chiropractic Care to Correct Vertebral Subluxation: A Retrospective Analysis
Erin L. Elster, D.C. Bio
[August 2, 2004, pp 1-9]
Objective: The objective of this article is threefold: to examine the role of head and neck trauma as a contributing factor to the onset of Multiple Sclerosis (MS) and Parkinson’s disease (PD); to explore the diagnosis and treatment of trauma-induced injury to the upper cervical spine through the use of protocol developed by the International Upper Cervical Chiropractic Association (IUCCA); and to investigate the potential for improving and arresting MS and PD through the correction of traumainduced upper cervical injury. Data from 81 MS and PD patients who recalled prior trauma, presented with upper cervical injuries, and received care according to the above protocol are
reviewed.

Clinical Features: Each patient was examined and cared for in the author’s private practice in an uncontrolled, non-randomized environment over a five-year period. Of the 81 MS and PD patients, 78 recalled that they had experienced at least one head or neck trauma prior to the onset of the disease. In order of frequency, patients reported that they were involved in auto accidents (39 patients); sporting accidents, such as skiing, horseback riding, cycling, and football (29 patients); or falls on icy sidewalks or down stairs (16 patients). The duration between the traumatic event and disease onset varied from two months to 30 years.

Intervention and Outcome: Two diagnostic tests, paraspinal digital infrared imaging and laser-aligned radiography, were performed according to IUCCA protocol. These tests objectively identify trauma-induced upper cervical subluxations (misalignment of the upper cervical spine from the neural canal) and resulting neuropathophysiology. Upper cervical subluxations were found in all 81 cases. After administering treatment to correct their upper cervical injuries, 40 of 44 (91%) MS cases and 34 of 37 (92%) PD cases showed symptomatic improvement and no further disease progression during the care period.

Conclusion: A causal link between trauma-induced upper cervical injury and disease onset for both MS and PD appears to exist. Correcting the injury to the upper cervical spine through the use of IUCCA protocol may arrest and reverse the progression of both MS and PD. Further study in a controlled, experimental environment with a larger sample size is recommended.

You bet! And where are the MS Society's funds going??? If I read this correctly, 91% of treated MS patients showed SYMPTOM IMPROVEMENT AND NO DISEASE PROGRESSION OVER 5 YEARS. This avenue of exploration is a no-brainer for any MS patient with possible upper cervical injuries, and perhaps for every MS patient. A lot cheaper, and fewer side effects, than the MS drugs, for sure.

Now, if I could only locate an upper-cervical specialist nearby....

Thanks for this post, NZer!

[uprightdoc]

I was sent this via a friend in NZ
https://www.jvsr.com/abstracts/index.asp?id=205
Original Research
Eighty-One Patients with Multiple Sclerosis and Parkinson’s Disease Undergoing Upper Cervical Chiropractic Care to Correct Vertebral Subluxation: A Retrospective Analysis
Erin L. Elster, D.C. Bio

Conclusion: A causal link between trauma-induced upper cervical injury and disease onset for both MS and PD appears to exist. Correcting the injury to the upper cervical spine through the use of IUCCA protocol may arrest and reverse the progression of both MS and PD. Further study in a controlled, experimental environment with a larger sample size is recommended.

It's terrific study, which is why I sent Dr. Elster a copy of my book back in June. This is just the tip of the iceberg. What chiropactic needs now are more physiological studies using doppler scans and MRI for example. That requires serious funding which is seriously lacking.

[Ruthless67]

Great article NZer1. I’m just amazed at all the great research articles that TIMS members find and post that were done in the past 20 odd years or so that point to various vascular issues and MS.

I agree, MS_HOPE, “And where are the MS Society's funds going???”

I wanted to bring Dr. Bill Code's experience to Dr. Flanagan’s attention if he hasn’t seen the post yet. http://www.facebook.com/note.php?note_i ... 2832983940

The puzzle pieces are coming together! Just maybe we have all the edges done?

Lora

[kiwi]

Husband had first adjustment today. Very gentle as Chiro was a little scared after hearing his history and seeing the x-rays we had had done. Apparently the atlas is twisted and higher than it should be? and wedged up around the occipital? maybe I have this right... Doc Flanaghan, tried to get xrays on here for you to see, but can only get them on a word doc as disk we have them on won't allow them to be converted to photo pictures - and I'm a technophobe. Is there anyway that I can e-mail them to you to enable you to see them. Husband is scheduled for 2nd venoplasty 20/12. First one gave him much relief, stopped his choking, pain, fatigue, etc but sadly the symptoms are creeping back. He is full time in a wheel chair. Is it safe to have adjustments after this time - would be a couple of weeks after as chiro is closed over christmas/new year period. He said there is no rotation and adjustment was with a toggle board and one downward movement of hand onto upper neck region. Thanks for your time