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Petr75 wrote: ↑Tue Jan 16, 2024 11:46 am 2024 Jan 15
School of Public Health, Suzhou Medical College, Soochow University, China
Association of long-term exposure to various ambient air pollutants, lifestyle, and genetic predisposition with incident cognitive impairment and dementia
https://pubmed.ncbi.nlm.nih.gov/38225615/

Conclusions: Exposure to air pollution was found to be a significant contributing factor to cognitive impairment and dementia, and this association was not easily modified by an individual's genetic predisposition. However, adopting a healthy lifestyle may help to manage the risk of cognitive decline related to air pollution.

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MS


2023 Jun 15
The risk of dementia in multiple sclerosis and neuromyelitis optica spectrum disorder
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309000/

Conclusion

The risk of dementia was higher in MS and NMOSD patients than in the general population and the dementia risk in MS patients was higher than in NMOSD subjects. Therefore, clinicians should be vigilant regarding cognitive impairment in patients with MS and NMOSD. Furthermore, it is important for clinicians to consider potential causes of dementia beyond MS/NMOSD itself, as preventive and therapeutic approaches vary depending on the underlying etiology. Further investigations should be performed to determine the pathophysiology of increased risk of AD or vascular dementia in MS and NMOSD patients.

2024 Feb 15
Joint Exposure to Multiple Air Pollutants, Genetic Susceptibility, and Incident Dementia: A Prospective Analysis in the UK Biobank Cohort
https://pubmed.ncbi.nlm.nih.gov/38426188/

Conclusion: Our study provides evidence that joint exposure to multiple air pollutants substantially increases the risk of dementia, especially among individuals with high genetic susceptibility.
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2024 Mar 14
Air pollution, APOE genotype and risk of dementia among individuals with cardiovascular diseases: A population-based longitudinal study
https://pubmed.ncbi.nlm.nih.gov/38492747/
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MS

2022 Sep
The association of apolipoprotein E (ApoE) genotype and cognitive outcomes in multiple sclerosis; a systematic review and meta-analysis
https://pubmed.ncbi.nlm.nih.gov/38492747/

2024
Division of Population Health Research, Department of Precision Medicine, Korea National Institute of Health, Korea Disease Control and Prevention Agency
Association between short-term exposure to ambient air pollutants and biomarkers indicative of inflammation and oxidative stress: a cross-sectional study using KoGES-HEXA data
https://pubmed.ncbi.nlm.nih.gov/38494707/

Conclusions: Short-term exposure to ambient air pollutants may induce oxidative damage and pro-inflammatory roles, together with counter-regulatory anti-inflammatory response.

2024 Apr 9
Cancer Big Data Center, National Cancer Control Institute, National Cancer Center, South Korea
Association of ambient air pollution with hemoglobin levels and anemia in the general population of Korean adults
https://pubmed.ncbi.nlm.nih.gov/38594672/

Conclusions: This study provides the first evidence that long-term exposure to air pollution, especially PM10, is significantly associated with reduced hemoglobin levels and anemia in the general adult population.


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MS

January 9, 2017
The Impact of Hemoglobin Levels on Multiple Sclerosis
https://www.pharmacytimes.com/view/the- ... -sclerosis

2024 Apr 17
Joint Effects of Indoor Air Pollution and Maternal Psychosocial Factors During Pregnancy on Trajectories of Early Childhood Psychopathology
https://pubmed.ncbi.nlm.nih.gov/38634620/

Conclusions: Prenatal exposure to environmental pollutants and psychosocial factors was associated with internalizing and externalizing child behavior trajectories. Understanding joint effects of adverse exposure mixtures will facilitate targeted interventions to prevent childhood psychopathology.

2024 Apr 2
Association between short- and medium-term exposure to air pollutants and depressive episode using comprehensive air quality index among the population in South Korea
https://pubmed.ncbi.nlm.nih.gov/38574871/

..Conclusions: Short- and medium-term exposure of air pollution may be associated with an increased risk of depressive episodes, especially for cold season.

2024 Apr 23
Center for Public Health and Environmental Assessment, United States Environmental Protection Agency, USA
Associations between long-term exposure to air pollution and kidney function utilizing electronic healthcare records: a cross-sectional study
https://pubmed.ncbi.nlm.nih.gov/38654228/

Conclusions: One-year average PM2.5 was associated with reduced eGFRcr, while O3 and NO2 were inversely associated. Neither PM2.5 or O3 were associated with a first-time identification of CKD, NO2 was inversely associated. We recommend future research examining the relationship between air pollution and impaired renal function.

2024 Apr 3
Taipei European School, Taipei, Taiwan
An ecological analysis of associations between ambient air pollution and cancer incidence rates in Taiwan
https://pubmed.ncbi.nlm.nih.gov/38565820/

....Altogether, the results from this ecological study unravel that exposure to ambient air pollution is associated with the incidence of several non-lung cancer types.

2024 Jun 13
Department of Brain and Behavioral Sciences, University of Pavia, Italy
Disentangling Multiple Sclerosis heterogeneity in the French territory among genetic and environmental factors via Bayesian heritability analysis
https://pubmed.ncbi.nlm.nih.gov/38880029/

Conclusion: Overall, our analysis highlighted the interaction between genetic variability and environmental exposures linked to the region of birth as the main factor explaining MS variability within individuals born and residing in France. Among the environmental exposures prevalent in the Northern regions, and potentially interacting with genetic variability, lower vitamin D levels due to reduced sun exposure, higher obesity prevalence and higher pollution levels represent the main risk factors in influencing MS risk. These findings emphasize the importance of accounting for environmental factors linked to geographical location in the investigation of MS risk factors, as well as to further explore the influence of GxE interactions in modifying genetic risk.

2024 Jun 17
The association between the scarlet fever and meteorological factors, air pollutants and their interactions in children in northwest China
https://pubmed.ncbi.nlm.nih.gov/38884798/

..High O3 had the strongest effect at a 6-week delay, with an RR of 5.43 (95%CI: 1.74,16.96). The risk effect of high SO2 was strongest in the week of exposure, and the maximum risk effect was 1.37 (95%CI: 1.08,1.73). The interactions showed synergistic effects between high temperatures and O3, high pressure and high SO2, high nitrogen dioxide (NO2) and high particulate matter with diameter of less than 10 μm (PM10), respectively. In conclusion, high temperature, pressure, high O3 and SO2 were the most important factors affecting the occurrence of SF in children, which will provide theoretical support for follow-up research and disease prevention policy formulation.

Coronavirus and Air Pollution
hsph.harvard.edu
https://www.hsph.harvard.edu/c-change/s ... pollution/

We know that air pollution can cause health problems, like heart attacks, strokes, diabetes and high blood pressure, that have been identified as the pre-existing medical conditions that raise the chances of death from COVID-19 infection. Emerging research, including a study from Harvard T.H. Chan School of Public Health, finds that breathing more polluted air over many years may itself worsen the effects of COVID-19.

The Harvard Chan study led by Xiao Wu and Rachel Nethery and senior author Francesca Dominici found an association between air pollution over many years with an 11% increase in mortality from COVID-19 infection for every 1 microgram/cubic meter increase in air pollution (for comparison, many Americans breathe air with 8 micrograms/cubic meter of particulate matter).

While the study does not show that air pollution directly affects an individual’s likelihood of dying from COVID-19 because individual-level COVID data is not yet publicly available, it does show an association between long term exposure to air pollution and higher COVID-19 mortality rates.

2024 May 9
Long-term exposure to air pollution on cardio-respiratory, and lung cancer mortality: a systematic review and meta-analysis
https://pubmed.ncbi.nlm.nih.gov/38887768/

Air pollution is a major cause of specific deaths worldwide...

2024 Jun 14
Joint effects of air pollution and genetic susceptibility on incident primary open-angle glaucoma
https://pubmed.ncbi.nlm.nih.gov/38880145/

Conclusion: Long-term air pollutant exposure was associated with an increased risk of POAG incidence, particularly in the population with high genetic predisposition.

2023 Oct 19
Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands
Traffic-related air pollution, road traffic noise, and Parkinson's disease: Evaluations in two Dutch cohort studies
https://pubmed.ncbi.nlm.nih.gov/38912395/

Conclusions: Our findings suggest that NOx and road traffic noise are associated with an increased risk of PD. While the association with NOx has been shown before, further investigation into the possible role of environmental noise on PD is warranted.

2024 Jun
Association of Gaseous Ambient Air Pollution and Dementia-Related Neuroimaging Markers in the ARIC Cohort, Comparing Exposure Estimation Methods and Confounding by Study Site
https://pubmed.ncbi.nlm.nih.gov/38922331/

Discussion: Patterns of local variation in estimated air pollution concentrations differ by estimation method. Although we did not find strong evidence supporting impact of gaseous pollutants on brain changes detectable by MRI, point estimates suggested associations between higher exposure to CO, NOx, and NO2 and smaller regional brain volumes. Analyses of air pollution and dementia-related outcomes that do not adjust for location likely underestimate uncertainty and may be susceptible to confounding bias. https://doi.org/10.1289/EHP13906.