Re: Paleo Diet discussion
Posted: Mon Aug 27, 2018 9:26 am
let's play spot the study design flaws:
A Paleolithic Diet-Based Intervention Decreases Multiple Sclerosis Fatigue via Lipid Profile Changes (P2.358) (2018)
http://n.neurology.org/content/90/15_Supplement/P2.358
Abstract
Objective: To investigate associations between lipid profiles and fatigue in a cohort of progressive multiple sclerosis (MS) patients on a modified Paleolithic diet-based multimodal intervention.
Background: Fatigue is a frequent and debilitating MS symptom that affects between 52%–93% of MS patients. Pharmacological options for treating MS-associated fatigue are limited. Dietary interventions have shown particular promise for treating MS-associated fatigue.
Design/Methods: This study included 18 progressive MS patients who participated in a prospective longitudinal study of fatigue following a modified Paleolithic diet-based multimodal intervention that included neuromuscular stimulation and stress reduction. Fatigue was measured on the Fatigue Severity Scale (FSS) at baseline and every 3 months for 12 months. A lipid profile consisting of high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC) and triglycerides (TG) was obtained on fasting blood samples at baseline and 12 months.
Results: The FSS score decreased from a mean of 5.51 ± 1.31 at baseline to 3.03 ± 1.6 at 12-months. The modified Paleolithic-diet based multimodal intervention was associated with increases in HDL-C (p = 0.049) and with decreases in BMI (p < 0.001), TG (p = 0.001), TG to HDL-C ratio (p = 0.002) and TC to HDL-C ratio (p = 0.018) over 12-months. Improvements in FSS were associated with greater HDL-C (p = 0.028) and lower TC (p = 0.005) at 12 months. TC (p = 0.039), HDL-C (p = 0.008) and TG to HDL-C ratio (p = 0.042) were associated with 3-month sustained improvement of > 2 FSS points.
Conclusions: Lipid profile variables are associated with the improvements in fatigue in progressive MS patients on a modified Paleolithic diet-based multimodal intervention.
aside - missing from disclosures: Dr Wahls arrived at her msdx as a vegetarian. for her, paleo represents a pendulum swing to the other extreme.
A Paleolithic Diet-Based Intervention Decreases Multiple Sclerosis Fatigue via Lipid Profile Changes (P2.358) (2018)
http://n.neurology.org/content/90/15_Supplement/P2.358
Abstract
Objective: To investigate associations between lipid profiles and fatigue in a cohort of progressive multiple sclerosis (MS) patients on a modified Paleolithic diet-based multimodal intervention.
Background: Fatigue is a frequent and debilitating MS symptom that affects between 52%–93% of MS patients. Pharmacological options for treating MS-associated fatigue are limited. Dietary interventions have shown particular promise for treating MS-associated fatigue.
Design/Methods: This study included 18 progressive MS patients who participated in a prospective longitudinal study of fatigue following a modified Paleolithic diet-based multimodal intervention that included neuromuscular stimulation and stress reduction. Fatigue was measured on the Fatigue Severity Scale (FSS) at baseline and every 3 months for 12 months. A lipid profile consisting of high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC) and triglycerides (TG) was obtained on fasting blood samples at baseline and 12 months.
Results: The FSS score decreased from a mean of 5.51 ± 1.31 at baseline to 3.03 ± 1.6 at 12-months. The modified Paleolithic-diet based multimodal intervention was associated with increases in HDL-C (p = 0.049) and with decreases in BMI (p < 0.001), TG (p = 0.001), TG to HDL-C ratio (p = 0.002) and TC to HDL-C ratio (p = 0.018) over 12-months. Improvements in FSS were associated with greater HDL-C (p = 0.028) and lower TC (p = 0.005) at 12 months. TC (p = 0.039), HDL-C (p = 0.008) and TG to HDL-C ratio (p = 0.042) were associated with 3-month sustained improvement of > 2 FSS points.
Conclusions: Lipid profile variables are associated with the improvements in fatigue in progressive MS patients on a modified Paleolithic diet-based multimodal intervention.
aside - missing from disclosures: Dr Wahls arrived at her msdx as a vegetarian. for her, paleo represents a pendulum swing to the other extreme.
well randomized and controlled is better at least. as usual, specifics for either diet - including the degree to which each conforms to standard public health info - would be informative, but is missing.