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Futility of Autoimmune Orthodoxy in MS Research--Editorial
Posted: Thu Jul 01, 2010 6:57 am
by Shayk
Here's an interesting editorial by Peter Behan, taken from the
Journal of Expert Review Neurotherapeutics
Futility of Autoimmune Orthodoxy in MS Research
“Experimental allergic encephalomyelitis is … a true autoimmune
disorder.
It has been accepted as an animal model of multiple
sclerosis …
However, a false orthodoxy claiming that multiple
sclerosis is an autoimmune disorder has developed and formed
the present basis of treatment, drug trials and research.
The outcome of this misplaced creed has been truly catastrophic.”
The entire editorial is freely available.
To those with similar sentiments, enjoy.
Sharon
Posted: Thu Jul 01, 2010 10:58 am
by cheerleader
thanks, Sharon. Great read.
The cost in misery, morbidity and mortality for humans in these trials cannot be measured. Even 15 years ago, Gulcher et al. commented: “it could be argued that over the years the autoimmune hypotheses have been harmful to a considerable number of patients” [19]. Given such data, as has been presented in this article, it is very difficult to understand why this theory of the pathogenesis of MS has monopolized MS research.
A closer relationship between the laboratory and the clinic, and alternate viewpoints on the prime pathology, the association of MS with diseases of Schwann cells, are needed. The vast and growing literature on trophic factors and molecular development abnormalities operating locally and distally holds potential rewards. It is clear that modern research should move away from the autoimmunity theory and look to the exciting advances in glial cell research and in the cristopathies.
Schwann cell disease and peripheral neuropathy is also linked to chronic venous insufficiency and ulceration in the legs.
cheer
Posted: Sat Jul 03, 2010 4:42 am
by shye
The vast and growing literature on trophic factors and molecular development abnormalities operating locally and distally holds potential rewards
Swank comes to mind...
Re: Futility of Autoimmune Orthodoxy in MS Research--Editori
Posted: Sat Jul 03, 2010 7:46 am
by HarryZ
To those with similar sentiments, enjoy.
Sharon
Sharon,
Is this paper an addition to Behan's "Pathogenesis of MS" which he wrote a number of years ago or the same one?
After reading that, one can only shake their head in disgust at the established world of MS research. These scientists have been researching MS for some 70 years using the autoimmune theory and still can't give us a cause!
Harry