Necrostatin is a lot like N-Acetyl Cysteine, but it is a drug that is being developed.
Interesting for those who like low fat diets and antioxidants.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919773/
"Increased production of free arachidonic acid occurs during brain ischemia and inflammation as a result of activation of phospholipases [14]. Arachidonic acid is a substrate for cycloxy-genases and lipoxygenases (LOX). Metabolism of arachidonic acid through these two enzyme systems is a potential source for free radicals and peroxides and thus oxidative damage. Altered arachidonic acid metabolism has been implicated in cerebral ischemic injury, neurode-generative diseases and psychiatric disorders [15]."
And some really good information in regard to autoimmune diseases and dietary supplements:
http://www.sage-hindawi.com/journals/ad/2010/249842/
Necrostatins at a glance
• Discovered by Harvard researchers
• Can inhibit programmed cell death
• Vast range of potential applications — cardiovascular, neurological, organ failure and more
• Licensed by TetraLogic, which will file FDA application in 2010
• Several animal trials now under way in Boston area
• Human trials slated for next year(2011)
http://www.masshightech.com/stories/200 ... friendform
Necrostatin-1 and Vitamin K Research
Necrostatin-1 and Vitamin K Research
Last edited by MSBOB on Thu Mar 17, 2011 8:07 pm, edited 1 time in total.
Here is a PDF if you like that.It displays a pronounced protective effect in a mouse model of ischemic brain injury and inhibits myocardial cell death. Inhibits RIP1 kinase the key upstream kinase involved in the activation of necroptosis (EC50=180nM).
http://www.enzolifesciences.com/BML-AP3 ... ostatin-1/
http://www.ijppp.org/files/IJPPP1005001.pdf
This looks like a very promising low toxic drug that may be able to help people someday. I hope you enjoy.
It is very nifty in that it is a small molecule that can be administered orally, pass through the blood brain barrier, and block a pathway of arachodonic acid from producing a hormone that programs cell death. It is also an antioxidant.
Arachidonic acid is one of the most abundant fatty acids in the brain, and plays a key role in inflammation.
Arachidonic acid is one of the most abundant fatty acids in the brain, and plays a key role in inflammation.
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