all things vitamin D

Discuss herbal therapies, vitamins and minerals, etc. here
User avatar
jimmylegs
Volunteer Moderator
Posts: 12592
Joined: Sat Mar 11, 2006 3:00 pm

still Ca! smh Re: vit D

Post by jimmylegs »

looks like the calcium blinkers are still on firmly ... :

https://www.mdpi.com/2072-6643/14/8/1575/htm

still waiting for someone to bother tracking other things, like perhaps magnesium intakes, balance, and serum levels before and after high dose d3 over multi-year time frames.

i continue to wonder about d3 excretion at higher intakes - i'd still like to have a better understanding of what was going on in this study:

Soft-tissue mineralization of bullfrog larvae (Rana catesbeiana) at a wastewater treatment facility (2010)
https://www.mdpi.com/2072-6643/14/8/1575/htm

"Total serum calcium concentrations of tadpoles and calcium concentrations in water samples did not differ significantly
with increasing distance from the discharge site. Affected tadpoles had elevated cholecalciferol (25-OHvitamin D3) levels. ... The prevalence of lesions was correlated with proximity of cells to the initial wastewater discharge site, and 28.5% of bullfrog larvae in the first cells had lesions. None were affected in the fifth cells."

i think we've seen elsewhere in human studies (TBD), that renal calcification can happen in consequence of high d3 intake, and without elevated serum calcium levels...

after over a decade, i'm finally nearing the bottom of my little bottle of 1,000,000 IU/gm drops. when it's done, i'm going to switch to a sublingual spray. i'm really interested in dose response, ie how many 1000Iu sprays to maintain a 125-150 nmol/l serum level. TBD.

here's hoping that firing d3 straight into my bloodstream that way, will help minimize any potentially damaging downstream effects!
active members shape site content. if there is a problem, speak up!
use the report button to flag problematic post content to volunteer moderators' attention.
User avatar
jimmylegs
Volunteer Moderator
Posts: 12592
Joined: Sat Mar 11, 2006 3:00 pm

Re: all things vitamin D

Post by jimmylegs »

so recently, my level tested at 100 nmol/l and the specialist said get it to 150. i'm still using up this ancient vial of hi-test drops, and dosing with a worn out dropper that can't be read for trying. i just did some dose response math based on current regimen and level, figured i'll add one extra drop a week, and see what happens. result: 157 nmol/l - not too shabby for guesswork!
active members shape site content. if there is a problem, speak up!
use the report button to flag problematic post content to volunteer moderators' attention.
User avatar
jimmylegs
Volunteer Moderator
Posts: 12592
Joined: Sat Mar 11, 2006 3:00 pm

Re: all things vitamin D

Post by jimmylegs »

just realized it's time for the midweek D3 'mystery megadose'

meanwhile, just spotted this in the mainstream media:

How an increasingly popular supplement landed a man in the hospital
https://www.ctvnews.ca/health/how-an-in ... -1.5976411

content typically vacant where level targets, and any cofactor considerations (other than Ca) are concerned!

smh
active members shape site content. if there is a problem, speak up!
use the report button to flag problematic post content to volunteer moderators' attention.
User avatar
NHE
Volunteer Moderator
Posts: 6227
Joined: Sat Nov 20, 2004 3:00 pm
Contact:

Re: all things vitamin D

Post by NHE »

jimmylegs wrote: Wed Jul 06, 2022 11:51 am meanwhile, just spotted this in the mainstream media:

How an increasingly popular supplement landed a man in the hospital
https://www.ctvnews.ca/health/how-an-in ... -1.5976411
That person took 50,000 IU 3x/day! That's an insanely huge dose. When I was vitamin D deficient at 8 ng/mL, I took 50,000 IU 1/week for 10 weeks. This protocol brought my level back up to 47 ng/mL. I now take 5000 IU/day just to keep my level stable in the 45 ng/mL range.
User avatar
jimmylegs
Volunteer Moderator
Posts: 12592
Joined: Sat Mar 11, 2006 3:00 pm

Re: all things vitamin D

Post by jimmylegs »

it was nuts for sure.
the most i ever do (or recommend to others if results suggest it'd be useful) is the established 50K IU/d x 10 d approach, then re-check levels.
i like the quick results after a 500,000 IU input total over 10 days - and conveniently, some bottles of drops are exactly that much total - 500 drops. :)
active members shape site content. if there is a problem, speak up!
use the report button to flag problematic post content to volunteer moderators' attention.
User avatar
jimmylegs
Volunteer Moderator
Posts: 12592
Joined: Sat Mar 11, 2006 3:00 pm

Re: all things vitamin D

Post by jimmylegs »

very nice to see :)

Zinc and its role in vitamin D function (2022)
https://www.sciencedirect.com/science/a ... 4122000190

recalling this frustrating 2014 thread
viewtopic.php?p=223430#p223430
active members shape site content. if there is a problem, speak up!
use the report button to flag problematic post content to volunteer moderators' attention.
User avatar
jimmylegs
Volunteer Moderator
Posts: 12592
Joined: Sat Mar 11, 2006 3:00 pm

Re: all things vitamin D

Post by jimmylegs »

so i recently, FINALLY used up my ultra potent D3 drops that i knew 6 drops a week was enough.
with that gone, i decided to try off the shelf sublingual. started with 4K IU/d. went for a test, levels came back 200 nmol/l :O
and that one specialist said sublilngual wouldn't work. agree to disagree!
have backed off to 3000 IU/d now.
active members shape site content. if there is a problem, speak up!
use the report button to flag problematic post content to volunteer moderators' attention.
Jaded
Family Elder
Posts: 439
Joined: Tue Jul 26, 2005 2:00 pm

Re: all things vitamin D

Post by Jaded »

Hi JL

Good to hear you found what works for you.

I take a 5000IU supp but not every day. My last test in Dec 2022 showed a reading of 99nmol/l which was up from 85 the Feb before. Guess I need to take it more often :/ (The NHS range for my age is 51-250)

Not sure what to make of that!
Jaded
Family Elder
Posts: 439
Joined: Tue Jul 26, 2005 2:00 pm

Re: all things vitamin D

Post by Jaded »

Oh my serum calcium was 2.26 mmol/l last Dec and I just had a dexa scan showing osteporosis in right hip and ostepoeania in lower spine & left hip. That's the only bit they scanned!

Been on HRT for years so feel a bit WTF?! But my mum has had osteoporosis for years

I am back on the dairy...
User avatar
NHE
Volunteer Moderator
Posts: 6227
Joined: Sat Nov 20, 2004 3:00 pm
Contact:

Re: all things vitamin D

Post by NHE »

I took 5000 IU/day for about a year. My spasticity became much worse. I would have whole body spasms about every 30 min. I had my D3 tested. It was 91.8 ng/mL! I took a month off and then went to 5000 IU/wk. I've been at this dosage for 5 months. It's time to get retested again.
User avatar
jimmylegs
Volunteer Moderator
Posts: 12592
Joined: Sat Mar 11, 2006 3:00 pm

Re: all things vitamin D

Post by jimmylegs »

always a balancing act, for sure!
the reference range here is 75-250nmol/l. based on the literature for healthy controls though, I zero in on 125-150 nmol/l.
i don't seem to have a calcium result handy but i feel like mine has been around 9 - so 2.26 mmol/l certainly sounds like one to work on.
yikes 91.8 ng/ml with spasms sounds like 5000IU/d D3 dragged the magnesium into the basement. that's what happened to me, way back when. NOT FUN.
active members shape site content. if there is a problem, speak up!
use the report button to flag problematic post content to volunteer moderators' attention.
User avatar
NHE
Volunteer Moderator
Posts: 6227
Joined: Sat Nov 20, 2004 3:00 pm
Contact:

Re: all things vitamin D

Post by NHE »

Jimmylegs wrote:yikes 91.8 ng/ml with spasms sounds like 5000IU/d D3 dragged the magnesium into the basement. that's what happened to me, way back when. NOT FUN.
Yes and that was with taking 400 mg/day of MgGlycinate, 200 mg in the morning and 200 mg in the evening. D3 At 5000 IU/day was my neuro’s recommendation - "Oh, I have all of my patients take 5000 IU/day.” BS. Without monitoring D3 levels, that’s a recipe for disaster.

BTW, my calcium was 9.2 mg/dL (2.96 mmol/L). The lab range was given as 8.7-10.2 mg/dL.
User avatar
NHE
Volunteer Moderator
Posts: 6227
Joined: Sat Nov 20, 2004 3:00 pm
Contact:

Re: all things vitamin D

Post by NHE »

Jaded wrote: Mon Jun 19, 2023 7:31 am Oh my serum calcium was 2.26 mmol/l last Dec and I just had a dexa scan showing osteporosis in right hip and ostepoeania in lower spine & left hip. That's the only bit they scanned!

Been on HRT for years so feel a bit WTF?! But my mum has had osteoporosis for years

I am back on the dairy...
Careful with high dose D3. This study found that it can lower bone mineral density.

viewtopic.php?p=258350#p258350
User avatar
NHE
Volunteer Moderator
Posts: 6227
Joined: Sat Nov 20, 2004 3:00 pm
Contact:

Re: all things vitamin D

Post by NHE »

Jaded wrote: Mon Jun 19, 2023 7:31 am Oh my serum calcium was 2.26 mmol/l last Dec and I just had a dexa scan showing osteporosis in right hip and ostepoeania in lower spine & left hip. That's the only bit they scanned!

Been on HRT for years so feel a bit WTF?! But my mum has had osteoporosis for years

I am back on the dairy...
Be careful with calcium supplements as well. It's best to get calcium from food sources. Calcium supplements have been found to cause hypercalcification in the blood which leads to calcium plating out in your arteries and veins.

Jaded
Family Elder
Posts: 439
Joined: Tue Jul 26, 2005 2:00 pm

Re: all things vitamin D

Post by Jaded »

Oh gosh NHE that does not sound like fun.

I've never taken a calcium supplement although my vitamin C supp has added calcium carbonate (190mg) and mag carbonate (104mg).

I take 5000IU D3 but not every day for sure. I don't go out in the sun due to previous melanoma so I only really get D from supplementation.

Suboptimal levels of D mean less absorption of calcium anyway so need on work on both. Nothing works in isolation!
Post Reply
  • Similar Topics
    Replies
    Views
    Last post

Return to “Natural Approach”