linkIn a study by our research group of a representative sample of individuals in the US [16], adults who consumed < 50% of the RDA of magnesium were found to be more likely to have elevated CRP than adults who consumed ≥ RDA (OR = 1.75; 95% CI = 1.08-2.87). Adults over age 40 with a BMI > 25 and less than half of the magnesium RDA were even more likely to have elevated CRP (OR = 2.24; 95% CI = 1.13-4.46). These results were maintained after controlling for demographic and cardiovascular risk factors. In a second cross-sectional study, we found that magnesium supplementation lowers the likelihood of elevated CRP in people with low dietary magnesium intake by 22% [17]. This observation suggests that not only does magnesium deficiency increase inflammation, but that magnesium supplementation may be a useful strategy for reduction of inflammation, especially in people with low levels of magnesium content from foods in the diet. The study also provides important epidemiologic support for the idea that it is the magnesium itself, rather than some other component of foods high in magnesium, that is responsible for the decreased likelihood of elevated CRP.
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