Preventing brain atrophy should be the gold standard
Posted: Sun Jul 07, 2013 3:22 pm
Commentary:
http://msj.sagepub.com/content/19/8/1007.full
cheer
http://msj.sagepub.com/content/19/8/1007.full
(answer: probably because relapses and white matter lesions have been used to prove efficiacy in DMDs--even though atrophy, disability and disease progression continue.)Cerebral atrophy has been used for centuries by pathologists as a marker of the loss of cerebral tissue due to injury or degeneration, and the tissue damage and loss associated with atrophy has been well documented. Thus, atrophy as a marker of neurodegeneration has incontrovertible face validity, at least over the long term. So, why is the use of whole brain atrophy as an outcome measure in multiple sclerosis (MS) the subject of debate?
cheer