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Researchers at Lund University in Sweden have published new research findings on the role of the intestinal barrier in the autoimmune disease multiple sclerosis (MS).

Within medical science, it is not known for certain how MS develops or why the body’s immune system attacks cells in the central nervous system. Inflammation develops for an unknown reason, which hinders transport of neural impulses. This can produce various physical and mental symptoms, including a loss of sensation, motor difficulties, blurred vision, dizziness and tiredness.

The present study investigates whether the function of the intestines is also attacked in MS. The results, obtained from a disease model of MS in mice, shows inflammation and changes in the barrier function of the intestines early in the course of the disease. The study has been published in the scientific journal PLOS ONE...... Read More- http://www.ms-uk.org/msetiology

The full paper is freely available.

http://www.plosone.org/article/fetchObj ... tation=PDF

Also see their prior work...

A novel probiotic mixture exerts a therapeutic effect on experimental autoimmune encephalomyelitis mediated by IL-10 producing regulatory T cells.

http://www.plosone.org/article/fetchObj ... tation=PDF

of course the intestinal barrier is damaged and of course a therapy starts here.
one reason could be a lack of cortisol when the HPA axis is affected.
zonulin is natural to help clean things.

these people better read this thread http://www.thisisms.com/forum/general-d ... 15188.html
and a whole new world will open for them.

Thanks for the link to the paper, NHE.
It's great that other researchers are picking up on Dr. Alessio Fasano's (University of Maryland) research into zonulin as a gatekeeper for the endothelium, and the overexpression of this protein allowing for gut (and blood brain barrier) permeability (commonly called "leaky gut.") Love seeing his work being referenced in the paper!
Here's more on Dr. Fasano's research from 2011.
http://ccsviinms.blogspot.com/2011/05/z ... brain.html

cheer

According to the following article, Dr. Alessio Fasano, now director of the Mucosal Immunology and Biology Research Center at Massachusetts General Hospital in Boston says (about gaps in the tight junctions) that "your genes likely help determine when and where these gaps appear, and also whether the particles that slip through produce an adverse reaction."

You Asked: Is Leaky Gut Syndrome a Real Thing?
Time, January 13, 2016
http://time.com/4178015/leaky-gut-syndrome-probiotics/

Keep in mind that vitamin D is involved in the function of MANY genes, including those involved in the tight junctions of the intestines. Both vitamin D and vitamin B12 are necessary for making DNA.