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Researchers presented a new mouse model for fatigue at the 2014 Society for Neuroscience meeting. The model is the first of its kind and works by manipulating the pro-inflammatory cytokine interleukin-1β.

There’s a new animal model coming down the pike that may be of use to multiple sclerosis researchers. At the Society for Neuroscience (SfN) annual meeting in Washington, D.C., researchers announced that they have developed a new mouse model for fatigue. This is the first mouse model to isolate fatigue from other symptoms..... Read More - http://www.ms-uk.org/mssymptomsresearch

The new model is getting closer than the old model.
But it is starting somewhere in the middle of the cascade.

The NF-KB is triggered by the biochemical cycle mechanism (the peroxydation), causing elevated inflammatory cytokines IL's, TFN and IFN that contribute to raising the inflammation and Th activity.

It will be difficult if not impossible to isolate fatigue from ohter symptoms, as in MS, it is all convolved.

Researchers should all open their minds and look at MS from the meta level.
This thread may give them some hints: http://www.thisisms.com/forum/general-d ... 15188.html