Page 1 of 1

MS drug 'may already be out there'

Posted: Wed Apr 01, 2015 2:12 am
by MSUK
Depression and heart-disease drugs are to be tested in a trial to find treatments for multiple sclerosis from existing medicines, reports the BBC.

There are currently no treatments in the secondary progressive stage of the condition and doctors hope the necessary drugs are already out there, but have never been tested on MS.

More than 400 people will take part in the trial at University College London and the University of Edinburgh..... Read more - http://www.ms-uk.org/MStypes

Re: MS drug 'may already be out there'

Posted: Wed Apr 01, 2015 9:08 am
by cheerleader
Proof that MS researchers haven't a clue what MS really is. But if they can make a buck, they will.
it's the throwing spaghetti to the ceiling to see if it sticks method of research.
Except these are human beings. And these drugs have side effects.

Insanity.
How about looking at nutrition, lifestyle and the vascular connection as Dr. Terry Wahls did to reverse her SPMS?
Or new research into cerebrospinal fluid levels and the link of MS to NPH?
http://www.thisisms.com/forum/general-d ... 26119.html
That makes too much sense, and not enough money.

cheer

Re: MS drug 'may already be out there'

Posted: Wed Apr 01, 2015 10:48 am
by lyndacarol
Last night (3/31/2015) I watched Episode 2: "The Blind Men and the Elephant" of the three-part PBS series, "Cancer: The Emperor Of All Maladies" (each part is 2 hours long).

http://video.pbs.org/video/2365450715/

There are so many comments that apply to MS as well as cancer:

@4:25… one great theme in cancer over the last hundred years, it's the men and women who said, "I'm not taking this anymore, I'm going to try something else." And that's how science and medicine are advanced – is by people refusing to take the status quo.
@6:24 Eric Lander, PhD, Director, Broad Institute: "Declaring war on something that you didn't understand at all was nuts."
@10:45 Susan Love, M.D., cancer surgeon: "When they didn't work, instead of saying, 'Hmm, maybe there's something wrong with this theory,' they said, 'Oh, we're just not cutting enough.'… But actually there was something wrong with the theory."
@11:00 Bernard Fisher, M.D. Pittsburgh surgeon: "I began to think, 'Well, we really don't know much about this disease we're treating… Why are we doing this?'
@14.00 Fisher quoted as saying, "In God we trust; all others must have data."
@14:40 Susan Love, M.D.: "The people at the academic centers and the people that were really hard-core, they didn't change. They had put their whole life into this; to say that they were wrong to themselves – I don't think they could admit it, even to themselves."
@17:24 Fisher had reminded the field: that treatment without understanding the underlying mechanism… could do enormous damage.
@17:40 Susan Love, M.D.: "What happens in medicine and the science is we come up with a story to explain our observations. And we get enamored of our story. And then we use that story to keep going on – it propels the research and it propels the kind of treatments you do. It's really only when you can't justify it anymore that we start to throw it out. But it lasts a lo-o-ong time… these stories."

Re: MS drug 'may already be out there'

Posted: Wed Apr 01, 2015 2:20 pm
by cheerleader
I'm watching the Emperor of All Maladies, too Lyndacarol---great series! I read the book years ago.
Thanks for linking those quotes. They sure do seem to fit!

But the difference is--- we do have a basic understand of what cancer is. It is the division of abnormal cells. And we know about the oncogenes. At least chemotherapy/antibody treatments have a target in killing cancer cells. I like the research of Dr. William Li, who is looking at the endothelium and starving cancer by anti-angiogenic means. Stopping new blood vessel growth, so that cancer cells will not be fed and multiply. It's a brilliant and safe preventative measure.



But researchers still do not know why MS occurs. There is no specific target. No gene. http://www.hindawi.com/journals/ad/2012/969657/
The immune reaction may be secondary, the EAE mouse model is not curing people, the current drugs which ablate the immune system do not stop progression.
http://www.medscape.com/viewarticle/805251
And continually throwing darts at humans, based on the EAE model, is hurting people and NOT moving research forward.

cheer