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Mouse mix-up leads to MS gender breakthrough

Posted: Fri May 29, 2015 1:27 am
by MSUK
A mistake made by a graduate student in a Northwestern Medicine lab, where she accidentally used male mice instead of female mice during an experiment, has led scientists to a novel discovery that offers new insight into why women are more likely than men to develop autoimmune conditions such as multiple sclerosis (MS).......... Read More - http://www.ms-uk.org/gender

Re: Mouse mix-up leads to MS gender breakthrough

Posted: Mon Jun 01, 2015 8:13 am
by Leonard
I think the gender bias is explained by the regulation and function of nNOS/eNOS/iNOS by sex hormones.
http://www.ncbi.nlm.nih.gov/pubmed/21559738

Higher NO in women together with the B-cells gives more peroxynitrite and thus jamming of the mitochondria.