This Is MS Multiple Sclerosis Knowledge & Support Community

Maybe this is what Coimbra is achieving.

http://www.ncbi.nlm.nih.gov/pubmed/26469335

Great to see researchers further describing how Vitamin D affects the vascular system, by making endothelial cells stronger in the face of inflammation. Sure important for people with MS! Here's the full pdf of the paper: http://www.ncbi.nlm.nih.gov/pmc/article ... 140370.pdf

Dietary Vitamin D and Its Metabolites Non- Genomically Stabilize the Endothelium
Our data suggests the presence of an alternative signaling modality by which D3 acts directly on endothelial cells to prevent vascular leak. The finding that D3 and its metabolites modulate endothelial stability may help explain the clinical correlations between low serum vitamin D levels and the many human diseases with well-described vas- cular dysfunction phenotypes.

This is why I included Vitamin D in the Endothelial Health Program--because it helps vessels maintain their integrity, and inhibits unwanted permeability. This was the paper I cited in the program back in 2007:
Ozlem Tarcin, Dilek Yavuz, Ahmet Toprak, Ahu Telli, Meral Yuksel, Dilek Yazici, Seda Sancak, Oguzhan Deyneli, Goncagul Haklar, Sema Akalin (2007). Effect of vitamin D replacement on endothelial function and oxidative stress in vitamin D deficient subjects. Endocrine Abstracts Vol. 14, 275

and here's the program:
http://ccsvi.org/index.php/helping-myse ... ial-health

cheer

cheerleader wrote:Great to see researchers further describing how Vitamin D affects the vascular system, by making endothelial cells stronger in the face of inflammation.

Correct me if I am wrong, but by saying the "endothelial cells" they are not specifically refering to vasculature only, it also implies arterial systems. I have not read the paper thoroughly so i may be wrong, but my guess would be that they were looking for actions/effects on the arterial walls.

Endothelial cells line veins and arteries. Although this study is on arterial endothelial cells, the fact that they refer to the "vasculature"--and reference such a "diverse array of inflammatory disease" and "altered hemodynamics" --which involve veins, as well as arteries--gives us a hint that this may be broader in application.

Here are some studies using Vitamin D on human umbilical cord vein endothelial cells. (HUVEC)---you can google for more, Cure. Suffice it to say, Vitamin D has similar anti-inflammatory and endothelial cell preservation on the venous side.
http://www.ncbi.nlm.nih.gov/pubmed/24285680
http://circ.ahajournals.org/content/128/23/2517.full
http://journals.plos.org/plosone/articl ... ne.0098527

cheer