Quantifying CCSVI
Posted: Fri Feb 12, 2016 12:54 pm
One of the markers of progress with CCSVI research is that we are seeing quantification. Here's an abstract:
http://phl.sagepub.com/content/early/20 ... 6.abstract
http://phl.sagepub.com/content/early/20 ... 6.abstract
Jugular blockages of a 90% stenosis causes a 10% pressure increase in the cerebral venous system. This is up to 1.3mmHg, not that I understand that unit of measurement in this context, but it seems nicely quantified. My stenoses were 80% and 99% respectively (right jugular and left jugular) so I relate quite well to the idea that I had a 10% pressure increase and that was a major contributor to my symptoms.Impact of CCSVI on cerebral haemodynamics: a mathematical study using MRI angiographic and flow data
LO Müller1,2
EF Toro2
EM Haacke3,4
D Utriainen4
1Computer Science Department, National Laboratory for Scientific Computing, LNCC/MCTI, Petrópolis, RJ, Brazil
2Laboratory of Applied Mathematics, Department of Civil, Environmental and Mechanical Engineering, University of Trento, Trento, Italy
3Department of Biomedical Engineering, Wayne State University, Detroit, MI, USA
4Magnetic Resonance Innovations, Inc. Detroit, MI, USA
LO Müller, Computer Science Department, National Laboratory for Scientific Computing, LNCC/MCTI, Av. Getúlio Vargas, 333, Petrópolis, 25651-075, RJ, Brazil. Email: lmuller@lncc.br
Abstract
Background
The presence of abnormal anatomy and flow in neck veins has been recently linked to neurological diseases. The precise impact of extra-cranial abnormalities such as stenoses remains unexplored.
Methods Pressure and velocity fields in the full cardiovascular system are computed by means of a global mathematical model that accounts for the relationship between pulsating cerebral blood flow and intracranial pressure.
Results
Our model predicts that extra-cranial strictures cause increased pressure in the cerebral venous system. Specifically, there is a predicted pressure increase of about 10% in patients with a 90% stenoses. Pressure increases are related to significant flow redistribution with flow reduction of up to 70% in stenosed vessels and consequent flow increase in collateral pathways.
Conclusions
Extra-cranial venous strictures can lead to pressure increases in intra-cranial veins of up to 1.3 mmHg, despite the shielding role of the Starling resistor. The long-term clinical implications of the predicted pressure changes are unclear.