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The MRZH reaction was a test in which antibodies against viruses of Measles, Rubella, varicella Zoster or Herpes was shown. It was shown that it happened with a higher frequency in MS than any other chronic disease.

It was showing only 67% specificity, much less than other tests like oligoclonal bands, but a new article points out that these two tests are not alternative but complementary, being able to diagnose 97% of cases, including non-european cases (which show less oligoclonal bands)

MRZH reaction increases sensitivity for intrathecal IgG synthesis in IgG Oligoclonal band negative Multiple Sclerosis patients

http://www.sciencedirect.com/science/ar ... 2816303265

I answer myself to update about the same subject with a new article:

https://www.ncbi.nlm.nih.gov/pubmed/27759441

Validation of a multiplexing technique to determine the intrathecal, polyspecific antiviral immune response in multiple sclerosis.

Beside the determination of oligoclonal bands (OCBs) as a diagnostic biomarker in multiple sclerosis (MS), the presence of an intrathecal production of antibodies against the neurotropic viruses measles (M), rubella (R) and Varicella-Zoster (Z), the so called MRZ reaction (MRZR) is an even more specific diagnostic biomarker in MS.

METHODS:

We compared and validated the determination of the MRZR in 97 cerebrospinal fluid (CSF) and serum sample pairs of a bead-based multiplexing technique and a classical enzyme-linked immunosorbent assay (ELISA).

RESULTS:

Conformity of 94% (M), 94% (R), 94% (Z), 96% (H) and 97% for the interpretation of the MRZR was obtained.

CONCLUSION:

Based on our findings of high conformity between the multiplex technique and classical ELISA, as well as the time and cost savings multiplexing allows, we conclude that the multiplexing technique is applicable as a diagnostic tool for the determination of the MRZR.