Tropospheric ozone
Re: Tropospheric ozone
O3
2023 Jun 22
Ozone Environmental Pollution: Relationship between the Intestine and Neurodegenerative Diseases
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376557/
Repeated exposure to environmental ozone causes a chronic state of oxidative stress. This state is present in chronic degenerative diseases and induces a loss of control of the inflammatory response. Redox system dysfunction and failures in control of inflammatory responses are involved in a vicious circle that maintains and increases the degenerative process. The intestine also responds to secondary reactive species formed by exposure to ozone doses, generating noxious stimuli that increase degenerative damage...
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MS
2024 Feb 26
Inflammatory bowel disease is associated with multiple sclerosis or Hodgkin lymphoma
https://pubmed.ncbi.nlm.nih.gov/38407888/
2023 Jun 22
Ozone Environmental Pollution: Relationship between the Intestine and Neurodegenerative Diseases
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376557/
Repeated exposure to environmental ozone causes a chronic state of oxidative stress. This state is present in chronic degenerative diseases and induces a loss of control of the inflammatory response. Redox system dysfunction and failures in control of inflammatory responses are involved in a vicious circle that maintains and increases the degenerative process. The intestine also responds to secondary reactive species formed by exposure to ozone doses, generating noxious stimuli that increase degenerative damage...
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MS
2024 Feb 26
Inflammatory bowel disease is associated with multiple sclerosis or Hodgkin lymphoma
https://pubmed.ncbi.nlm.nih.gov/38407888/
https://www.eboro.cz
Re: Tropospheric ozone
O3
2024 Feb 20
Exposure to Ozone Downregulates Bcl-2 and Increases Executing Caspases-3 and -8 in the Hippocampus, Frontal Cortex, and Cerebellum of Rats
https://pubmed.ncbi.nlm.nih.gov/38516464/
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MS
2020
JNK and phosphorylated Bcl-2 predict multiple sclerosis clinical activity and glatiramer acetate therapeutic response
https://www.sciencedirect.com/science/a ... 1619304619
..p-Bcl-2 levels are significantly decreased in RRMS patients during relapses
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Published: December 1999
Involvement of caspases in cytotoxic cytokine-mediated oligodendrocyte cell death
https://link.springer.com/article/10.1007/BF01288207
.. Our results suggest that the inhibition of caspases may be a novel approach to treat multiple sclerosis.
2024 Feb 20
Exposure to Ozone Downregulates Bcl-2 and Increases Executing Caspases-3 and -8 in the Hippocampus, Frontal Cortex, and Cerebellum of Rats
https://pubmed.ncbi.nlm.nih.gov/38516464/
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MS
2020
JNK and phosphorylated Bcl-2 predict multiple sclerosis clinical activity and glatiramer acetate therapeutic response
https://www.sciencedirect.com/science/a ... 1619304619
..p-Bcl-2 levels are significantly decreased in RRMS patients during relapses
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Published: December 1999
Involvement of caspases in cytotoxic cytokine-mediated oligodendrocyte cell death
https://link.springer.com/article/10.1007/BF01288207
.. Our results suggest that the inhibition of caspases may be a novel approach to treat multiple sclerosis.
https://www.eboro.cz
Re: Tropospheric ozone
O3
Ozone enema modulated the TRPV1 and TRPV4 signaling in rats with anterior resection of rectum
https://www.researchgate.net/figure/Ozo ... _353749010
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MS
2024 Mar 23
Department of Molecular Cell Biology and Immunology, UMC Location Vrije Universiteit Amsterdam, The Netherlands
Inflammation-induced TRPV4 channels exacerbate blood-brain barrier dysfunction in multiple sclerosis
https://pubmed.ncbi.nlm.nih.gov/38521959/
Conclusion: Collectively, our findings suggest a novel role for endothelial TRPV4 in MS, in which enhanced expression contributes to MS pathogenesis by driving BBB dysfunction and immune cell migration.
Ozone enema modulated the TRPV1 and TRPV4 signaling in rats with anterior resection of rectum
https://www.researchgate.net/figure/Ozo ... _353749010
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MS
2024 Mar 23
Department of Molecular Cell Biology and Immunology, UMC Location Vrije Universiteit Amsterdam, The Netherlands
Inflammation-induced TRPV4 channels exacerbate blood-brain barrier dysfunction in multiple sclerosis
https://pubmed.ncbi.nlm.nih.gov/38521959/
Conclusion: Collectively, our findings suggest a novel role for endothelial TRPV4 in MS, in which enhanced expression contributes to MS pathogenesis by driving BBB dysfunction and immune cell migration.
https://www.eboro.cz
Re: Tropospheric ozone
O3
2024 Mar 7
Department of Occupational and Environmental Health Sciences, Peking University School of Public Health, and Peking University Institute of Environmental Medicine, Beijing, China
Low-level ambient ozone exposure associated with neutrophil extracellular traps and pro-atherothrombotic biomarkers in healthy adults
https://pubmed.ncbi.nlm.nih.gov/38523002/
Conclusions: Ambient O3 exposure was associated with significant increases in NETs and pro-atherothrombotic potential, even at exposure levels well below current air quality guidelines of the World Health Organization.
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MS
June 2021
Neutrophil-lymphocyte ratio as a marker for disability and activity in multiple sclerosis
https://www.sciencedirect.com/science/a ... 4821001887
Highlights
•Neutrophil-lymphocyte ratio was significantly higher in multiple sclerosis (MS) patients compared to controls.
2024 Mar 7
Department of Occupational and Environmental Health Sciences, Peking University School of Public Health, and Peking University Institute of Environmental Medicine, Beijing, China
Low-level ambient ozone exposure associated with neutrophil extracellular traps and pro-atherothrombotic biomarkers in healthy adults
https://pubmed.ncbi.nlm.nih.gov/38523002/
Conclusions: Ambient O3 exposure was associated with significant increases in NETs and pro-atherothrombotic potential, even at exposure levels well below current air quality guidelines of the World Health Organization.
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MS
June 2021
Neutrophil-lymphocyte ratio as a marker for disability and activity in multiple sclerosis
https://www.sciencedirect.com/science/a ... 4821001887
Highlights
•Neutrophil-lymphocyte ratio was significantly higher in multiple sclerosis (MS) patients compared to controls.
https://www.eboro.cz
Re: Tropospheric ozone
O3
2023 Mar 29
Acute Ozone-Induced Transcriptional Changes in Markers of Oxidative Stress and Glucocorticoid Signaling in the Rat Hippocampus and Hypothalamus Are Sex-Specific
https://pubmed.ncbi.nlm.nih.gov/37047376/
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MS
2024 Feb 27
Hippocampal subfields and thalamic nuclei associations with clinical outcomes in multiple sclerosis: An ultrahigh field MRI study
https://pubmed.ncbi.nlm.nih.gov/38582026/
Background: Previous studies have shown that thalamic and hippocampal neurodegeneration is associated with clinical decline in Multiple Sclerosis (MS). However, contributions of the specific thalamic nuclei and hippocampal subfields require further examination. ...
2023 Mar 29
Acute Ozone-Induced Transcriptional Changes in Markers of Oxidative Stress and Glucocorticoid Signaling in the Rat Hippocampus and Hypothalamus Are Sex-Specific
https://pubmed.ncbi.nlm.nih.gov/37047376/
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MS
2024 Feb 27
Hippocampal subfields and thalamic nuclei associations with clinical outcomes in multiple sclerosis: An ultrahigh field MRI study
https://pubmed.ncbi.nlm.nih.gov/38582026/
Background: Previous studies have shown that thalamic and hippocampal neurodegeneration is associated with clinical decline in Multiple Sclerosis (MS). However, contributions of the specific thalamic nuclei and hippocampal subfields require further examination. ...
https://www.eboro.cz
Re: Tropospheric ozone
O3
2024 Apr 17
Maternal exposure to ambient ozone and fetal conotruncal heart defects in China: A multicenter cohort study
https://pubmed.ncbi.nlm.nih.gov/38636262/
Conclusions: Elevated maternal exposure to O3 during pregnancy, particularly in the perinatal period, is linked to an increased risk of fetal CTDs. Further longitudinal analyses are needed to validate these results.
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2024 Mar 30
Long-term ambient ozone exposure and incident cardiovascular diseases: National cohort evidence in China
https://pubmed.ncbi.nlm.nih.gov/38636234/
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MS
September 10, 2023
Multiple Sclerosis and Cardiovascular Disease: What's the Link?
https://www.verywellhealth.com/ms-heart-issues-5224960
.. The Link Between MS and Heart Issues
Several studies have suggested an association between MS and heart disease, and research is ongoing to understand their relationship.2
Elevated triglyceride
and LDL cholesterol (low-density lipoprotein, considered "bad") levels have been associated with worse MS symptoms and more brain imaging abnormalities.
2024 Apr 17
Maternal exposure to ambient ozone and fetal conotruncal heart defects in China: A multicenter cohort study
https://pubmed.ncbi.nlm.nih.gov/38636262/
Conclusions: Elevated maternal exposure to O3 during pregnancy, particularly in the perinatal period, is linked to an increased risk of fetal CTDs. Further longitudinal analyses are needed to validate these results.
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2024 Mar 30
Long-term ambient ozone exposure and incident cardiovascular diseases: National cohort evidence in China
https://pubmed.ncbi.nlm.nih.gov/38636234/
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MS
September 10, 2023
Multiple Sclerosis and Cardiovascular Disease: What's the Link?
https://www.verywellhealth.com/ms-heart-issues-5224960
.. The Link Between MS and Heart Issues
Several studies have suggested an association between MS and heart disease, and research is ongoing to understand their relationship.2
Elevated triglyceride
and LDL cholesterol (low-density lipoprotein, considered "bad") levels have been associated with worse MS symptoms and more brain imaging abnormalities.
https://www.eboro.cz
Re: Tropospheric ozone
O3
2024 Apr 16
Peripheral HMGB1 is linked to O3 pathology of disease-associated astrocytes and amyloid
https://pubmed.ncbi.nlm.nih.gov/38624088/
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MS
2020 Mar
HMGB1 as a potential new marker of disease activity in patients with multiple sclerosis
https://pubmed.ncbi.nlm.nih.gov/31728855/
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2015 Mar 11
Role of high mobility group box protein 1 (HMGB1) in peripheral blood from patients with multiple sclerosis
https://pubmed.ncbi.nlm.nih.gov/25879961/
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2016 Mar 31
Amyloid Proteins and Their Role in Multiple Sclerosis. Considerations in the Use of Amyloid-PET Imaging
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814935/
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2024 Mar
Disease-associated astrocyte epigenetic memory promotes CNS pathology
https://pubmed.ncbi.nlm.nih.gov/38509377/
.... Disease-associated astrocyte subsets contribute to the pathology of neurologic diseases, including multiple sclerosis and experimental autoimmune encephalomyelitis1-8 (EAE)
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2023 Jun 15
Alzheimer’s disease and multiple sclerosis: a possible connection through the viral demyelinating neurodegenerative trigger (vDENT)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10310923/
2024 Apr 16
Peripheral HMGB1 is linked to O3 pathology of disease-associated astrocytes and amyloid
https://pubmed.ncbi.nlm.nih.gov/38624088/
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MS
2020 Mar
HMGB1 as a potential new marker of disease activity in patients with multiple sclerosis
https://pubmed.ncbi.nlm.nih.gov/31728855/
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2015 Mar 11
Role of high mobility group box protein 1 (HMGB1) in peripheral blood from patients with multiple sclerosis
https://pubmed.ncbi.nlm.nih.gov/25879961/
----------
2016 Mar 31
Amyloid Proteins and Their Role in Multiple Sclerosis. Considerations in the Use of Amyloid-PET Imaging
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814935/
----------
2024 Mar
Disease-associated astrocyte epigenetic memory promotes CNS pathology
https://pubmed.ncbi.nlm.nih.gov/38509377/
.... Disease-associated astrocyte subsets contribute to the pathology of neurologic diseases, including multiple sclerosis and experimental autoimmune encephalomyelitis1-8 (EAE)
----------
2023 Jun 15
Alzheimer’s disease and multiple sclerosis: a possible connection through the viral demyelinating neurodegenerative trigger (vDENT)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10310923/
https://www.eboro.cz
Re: Tropospheric ozone
O3
2014 Jun
Iron decreases biological effects of ozone exposure
https://pubmed.ncbi.nlm.nih.gov/24862973/
..Context: Ozone (O₃) exposure is associated with a disruption of iron homeostasis and increased availability of this metal which potentially contributes to an oxidative stress and biological effects.
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MS
2024 Mar 21
Iron metabolism disorder and multiple sclerosis: a comprehensive analysis
https://pubmed.ncbi.nlm.nih.gov/38590521/
2014 Jun
Iron decreases biological effects of ozone exposure
https://pubmed.ncbi.nlm.nih.gov/24862973/
..Context: Ozone (O₃) exposure is associated with a disruption of iron homeostasis and increased availability of this metal which potentially contributes to an oxidative stress and biological effects.
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MS
2024 Mar 21
Iron metabolism disorder and multiple sclerosis: a comprehensive analysis
https://pubmed.ncbi.nlm.nih.gov/38590521/
https://www.eboro.cz
Re: Tropospheric ozone
Progway 08/2023
Last edited by Petr75 on Thu Apr 25, 2024 9:44 pm, edited 1 time in total.
https://www.eboro.cz
Re: Tropospheric ozone
O3
2024 Apr 18
Long-term exposure to ambient ozone and adult-onset asthma: A prospective cohort study
https://pubmed.ncbi.nlm.nih.gov/38642637/
..Conclusion: Our findings suggest a potential causal relationship between long-term exposure to high-level ambient O3 and increased risks of AOA.
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MS
#ACTRIMS2019 – Asthma More Common in MS Patients Than Public at Large, Study Finds
https://multiplesclerosisnewstoday.com/ ... udy-finds/
.. Asthma is significantly more common among patients with multiple sclerosis (MS) than in the general population, a new study shows. The increased prevalence was especially evident in younger and elderly MS patients, regardless of race or sex.
2024 Apr 18
Long-term exposure to ambient ozone and adult-onset asthma: A prospective cohort study
https://pubmed.ncbi.nlm.nih.gov/38642637/
..Conclusion: Our findings suggest a potential causal relationship between long-term exposure to high-level ambient O3 and increased risks of AOA.
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MS
#ACTRIMS2019 – Asthma More Common in MS Patients Than Public at Large, Study Finds
https://multiplesclerosisnewstoday.com/ ... udy-finds/
.. Asthma is significantly more common among patients with multiple sclerosis (MS) than in the general population, a new study shows. The increased prevalence was especially evident in younger and elderly MS patients, regardless of race or sex.
https://www.eboro.cz
Re: Tropospheric ozone
Petr75 wrote: ↑Mon Jan 24, 2022 12:00 pm 18 November 2021
School of Public Health, Capital Medical University, China
The association between ozone and ischemic stroke morbidity among patients with type 2 diabetes in Beijing, China
https://www.sciencedirect.com/science/a ... 9721068091
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2022 Jan 6
Nanshan School, Guangzhou Medical University, China
Myocardial infarction and stroke risks in multiple sclerosis patients: A two-sample Mendelian randomization study
https://pubmed.ncbi.nlm.nih.gov/35066269/.....
2024 Apr 4
Second Department of Neurology, School of Medicine, "Attikon" University Hospital, National and Kapodistrian University of Athens, Greece
Prevalence and epidemiology of stroke in patients with multiple sclerosis: a systematic review and meta-analysis
https://pubmed.ncbi.nlm.nih.gov/38573365/
..Conclusion: The findings of the present meta-analysis indicate that MS is associated with an increased risk for ischaemic and haemorrhagic stroke. Future well-designed epidemiological studies are warranted to corroborate the robustness of the present findings in the MS population.
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2023 Aug
The Prevalence of Diabetes Mellitus Type II (DMII) in the Multiple Sclerosis Population: A Systematic Review and Meta-Analysis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420178/
..Additionally, there is a need for more studies structured around the interactions of MS and DMIΙ and assessing the direction of potential causation between those two conditions.
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May 2024
sciencedirect.com
The risk of type 2 diabetes mellitus in multiple sclerosis and neuromyelitis optica spectrum disorder: A nationwide cohort study
https://www.sciencedirect.com/science/a ... 4824000981
..The risk of developing T2DM was 1.54 times higher in patients with NMOSD than in control populations matched by age, sex, hypertension, and dyslipidemia.
https://www.eboro.cz
Re: Tropospheric ozone
2024 Apr 23
Diurnal emission variation of ozone precursors: Impacts on ozone formation during Sep. 2019
https://pubmed.ncbi.nlm.nih.gov/38663597/
Abstract
With the issue of ozone (O3) pollution having increasingly gained visibility and prominence in China, the Chinese government explored various policies to mitigate O3 pollution.
Diurnal emission variation of ozone precursors: Impacts on ozone formation during Sep. 2019
https://pubmed.ncbi.nlm.nih.gov/38663597/
Abstract
With the issue of ozone (O3) pollution having increasingly gained visibility and prominence in China, the Chinese government explored various policies to mitigate O3 pollution.
https://www.eboro.cz