This Is MS Multiple Sclerosis Knowledge & Support Community

I was looking at vilnietis doc on his levels and noticed his creainine went up from 72 before treatment to 86 mmol/l but 17 months, later came back down to 78.
Also, research has indicated the D is renal protective.
https://www.ncbi.nlm.nih.gov/pubmed/22160397

Just wondering if anyone knows if D increases creatinine at high doses.

Well, it depends on each person.

But generally, it does not change. At least I never saw people complaining about their creatinine levels.

As you already know my brother takes huge doses (250,000 iu's) and some of his creatinine levels were:

10/21/14: 1 mg/dl
24/10/14: 0.9 mg/dl
08/10/15: 1.2 mg/dl
08/19/15: 1.1 mg/dl
02/27/16: 1 mg/dl
09/06/16: 1.10 mg/dl

Reference values:
Men.: 0.66 to 1.25 mg/dl
Women: 0.52 to 1.04 mg/dl

I do not have their 2017 exams on my laptop. But I know that it did not change because he would tell me.

Thanks for the example.
It does look like some fluctuation happens.
Do you know if there is a maximum calcium intake allowed by the protocol?
I know that calcium will make the PTH come down and could cause a false calculation on the D requirements.

-
-
The fluctuations seem very small.

When he was taking 180,000iu's (08/10/15 - 1.2 mg/dl) creatinine was higher than when he started to take 250,000iu's (02/27/16: 1 mg/dl)

Do you know if there is a maximum calcium intake allowed by the protocol?

No, there is not an exact upper limit of calcium intake. Because every patient is different and each one takes a different dose of vitamin D.

First, the patients need to reduce their calcium intake and follow a low-calcium diet.

Then after 2 or 3 months (for patients without kidneys problem) doctors check patient's exams and do an adjustment if necessary.

It works analogously as the vitamin D dose adjustments.