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Vitamin D resistance
Posted: Sun Apr 02, 2017 5:23 am
by mrtmeo
Is the goal with the vitamin D protocol to overcome resistance of 25 hydroxy D (storage D) conversion to 1,25 dihydroxy D (active D) or is it resistance on a cellular level?
Re: Vitamin D resistance
Posted: Sun Apr 02, 2017 11:49 am
by AntonioBR
mrtmeo wrote:Is the goal with the vitamin D protocol to overcome resistance of 25 hydroxy D (storage D) conversion to 1,25 dihydroxy D (active D) or is it resistance on a cellular level?
Well, the resistance happens in a genetic level.
By genetic mutations, alteration of the genetic code itself... Or/and changes caused by modification of gene expression (epigenetic factor).
The exact mechanism of this resistance is not clear yet.
Second Coimbra the resistance may also be due to an alteration of the enzymes dealing with the conversion and activation of vitamin D, which are two hydroxylases. So there are many different possibilities. The effect of such genetically altered vitamin D metabolism happens on several diseases - not only autoimmune disorders.
The epigenetic
hypothesis for some diseases seems very interesting and very plausible.
Re: Vitamin D resistance
Posted: Mon Apr 03, 2017 7:30 am
by mrtmeo
I guess I am looking at it from the perspective of if the acitve D form never gets high enuf no matter how much D the person takes, will this keep the person from obtaining remission or is it problem with VDRs themselves?
Yes, epigenitics explains it all how our environment has everything to do with our gene expressions.
Re: Vitamin D resistance
Posted: Mon Apr 03, 2017 8:32 am
by AntonioBR
mrtmeo wrote:I guess I am looking at it from the perspective of if the acitve D form never gets high enuf no matter how much D the person takes, will this keep the person from obtaining remission or is it problem with VDRs themselves?
It happens with both healthy people and those who have autoimmune diseases. The 1,25-vitamin D form ''almost'' does not change even if you take high doses of vit.D.
It is related with VDRs. And PTH - until now - it is the better form to measure it.
By the way talking about epigenetics there is a study published in march 29, 2017
Vitamin D receptor gene is epigenetically altered and transcriptionally up-regulated in multiple sclerosis:
http://journals.plos.org/plosone/articl ... ne.0174726