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I have just read in MS-UK that Simvastatin trial is gonna start ... 10 years late.

As it happened already with Rituxan, Simvastatin is a drug with a expired patent, and though patent expiration is supposed to be something for the public interest, the effect is that nobody has performed a real clinical trial in a lot of years.

Until now. Finally the MS Society, the NIHR and the National MS Society have found the funds. Maybe somebody around here with SPMS could be interested.

http://www.ms-uk.org/ms-patients-trial- ... ent-090517

http://www.thelancet.com/journals/lance ... S0140-6736(13%2962242-4/abstract

lipid peroxydation is the major issue in the progressive disease.
lowering LDL cholesterol will slow progression.

I have been doing my own trial for years. Simvastatin is almost the official drug of South Louisiana due to the diet around here...rich in fat.

So I'm just a testimonial. I have been taking (40mg) Simvastatin since 1996. I was dx'd with MS 2/2016 just a week before my 59 th birthday.

So, does Simvastatin slow the disease?
.......No because I got the disease.
.......Yes because I was dx'd at such a late age.

Looks like a more comprehensive test is needed....

FDA warnings about high-dose simvastatin use (80mg) from 2011:

https://www.fda.gov/Drugs/DrugSafety/ucm256581.htm