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Dialysis and Coimbra protocol

Posted: Fri May 12, 2017 10:23 am
by mrtmeo
I saw this study showing how hemodialysis can remove calcium from the blood and figure that it would work for those who are on dialysis and cannot drink the 2.5L of fluids per day.
https://www.ncbi.nlm.nih.gov/pubmed/160852

Abstract

The role of dialysis in the treatment of patients with severe hypercalcemia is uncertain. The fourteen previously reported cases of hypercalcemia treated with either peritoneal or hemodialysis have been reviewed. Two additional patients treated with hemodialysis are described in this report. Because the use of large volumes of intravenous fluids was contraindicated, each of the patients received a low calcium bath (0-1 mEq calcium per liter) hemodialysis for three and a half hours. After dialysis, the serum calcium fell to normal in both and remained normal thereafter with treatment of the underlying disease (multiple myeloma in one and vitamin D intoxication in the other). Hemodialysis can clear up to 682 mg of calcium per hour as compared to 124 mg per hour for peritoneal dialysis and 82 mg per hour with forced saline diuresis. Low calcium bath hemodialysis is indicated when the presence of renal and/or cardiac failure prevents the administration of large volumes of intravenous fluids to hypercalcemic patients.

Re: Dialysis and Coimbra protocol

Posted: Mon May 15, 2017 7:44 am
by AntonioBR
Very interesting.

Thank you mrtmeo

Re: Dialysis and Coimbra protocol

Posted: Mon May 15, 2017 9:40 am
by lyndacarol
I understand that plasmapheresis also removes calcium (among many other things) from the bloodstream. Sorry, I have no research to support my statement.

Re: Dialysis and Coimbra protocol

Posted: Sun Jul 09, 2017 8:09 pm
by mrtmeo
lyndacarol wrote:I understand that plasmapheresis also removes calcium (among many other things) from the bloodstream. Sorry, I have no research to support my statement.
The anti-coagulant usually used in plasmapheresis is citrate, which has a tendency to bind with calcium in the blood, potentially causing dangerously low calcium levels. To prevent this, calcium may be given intravenously (IV) or by mouth during the procedure.

https://www.iwmf.com/system/files/Plasm ... nglish.pdf