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Dalfampridine: old bird poison helps MS patients walking..
In Annels of neurology an editorial on 4-Aminopyridine: New Life For an Old Drug. Fampiridine we called in in the past, it was an old bird poising at one time long ago. I have reviewed clinical data of that old potassium channel inhibitor for symptomatic improvement of MS many years ago, in order to possibly licence it in for a certain pharmaceutical company. You could function a bit better, due to an improvement of impulse conductance of the nerves. At that time, many, many years ago, I felt that the symptomatic improvement was too little and the side effects to troublesome to put development energy into the drug. Since then various pharmaceutical industries must have looked into the files of fampiridine in MS. Now, the FDA approved the drug for walking difficulties in patients suffering from MS.