lack of a micro-RNA as a biomarker
Posted: Sat Dec 09, 2017 3:59 am
MicroRNAs are proposed as a biomarker of MS. When myelin is broken, some fragments of RNA appear in blood.
But a recent research has appeared pointing to the opposite. A microRNA (miR-219) normally present in controls, which is involved in the normal funtion of oligodendrocytes, is lacking in MS patients
Regulator of oligodendrocyte maturation, miR-219, a potential biomarker for MS
Source: https://jneuroinflammation.biomedcentra ... 017-1006-3
Conclusions
We have been able to identify and validate absence of miR-219 detection in CSF of MS patients compared to controls, suggesting that it may emerge as a candidate biomarker for MS diagnosis.
But a recent research has appeared pointing to the opposite. A microRNA (miR-219) normally present in controls, which is involved in the normal funtion of oligodendrocytes, is lacking in MS patients
Regulator of oligodendrocyte maturation, miR-219, a potential biomarker for MS
Source: https://jneuroinflammation.biomedcentra ... 017-1006-3
Conclusions
We have been able to identify and validate absence of miR-219 detection in CSF of MS patients compared to controls, suggesting that it may emerge as a candidate biomarker for MS diagnosis.