Patterns: Plasmapheresis confirmed as selective treatment.

[frodo]

Plasmapheresis has been confirmed a second time as a selective treatment for patterns I and II. This has been consistently reported since 2005.

Tissue Markers for Acute Multiple Sclerosis Treatment Response—A Step Toward Personalized Medicine
JAMA neurology, February 5, 2018

https://www.ncbi.nlm.nih.gov/pubmed/16099294 and
https://jamanetwork.com/journals/jamane ... irect=true

Extract:

Many of the same investigators involved in the original lesion pattern study applied their lesion classification schema to short-term response to treatment.

This retrospective study evaluated short-term clinical responses to apheresis (plasmapheresis), stratified by 3 of the 4 lesion patterns. Among those with T-cell mediated autoimmune pathology, 31% to 55% demonstrated functional response to apheresis.

Researchers suggested that T-cell mediated autoimmune pathology with antibody and complement activation (pattern 2) responded the best. None of the patients with oligodendrocytopathy (pattern 3) demonstrated improvement.

See also:

http://www.thisisms.com/forum/drug-pipe ... c4567.html

and

https://jamanetwork.com/journals/jamane ... irect=true (Feb. 2018)

and

https://jamanetwork.com/journals/jamane ... irect=true (Feb. 2018)