EBV: Leukocytes could be unable to control EBV infection.
Posted: Mon Apr 02, 2018 1:03 am
Human leukocytes have some proteins named "Human Leukocyte antigens (HLA) alleles". They are associated with disease susceptibility,
HLA alleles modulate EBV viral load in multiple sclerosis
https://translational-medicine.biomedce ... 018-1450-6
Background
The etiopathology of multiple sclerosis (MS) is believed to include genetic and environmental factors. Human leukocyte antigen (HLA) alleles, in particular, are associated with disease susceptibility, whereas Epstein Barr Virus (EBV) infection has long been suspected to play a role in disease pathogenesis. The aim of the present study is to evaluate correlations between HLA alleles and EBV infection in MS.
Conclusions
Host HLA-B*07 allele influence EBV VL in MS. As HLA-class I molecules present antigens to T lymphocytes and initiate immune response against viruses, these results could support a role for EBV in MS.
HLA alleles modulate EBV viral load in multiple sclerosis
https://translational-medicine.biomedce ... 018-1450-6
Background
The etiopathology of multiple sclerosis (MS) is believed to include genetic and environmental factors. Human leukocyte antigen (HLA) alleles, in particular, are associated with disease susceptibility, whereas Epstein Barr Virus (EBV) infection has long been suspected to play a role in disease pathogenesis. The aim of the present study is to evaluate correlations between HLA alleles and EBV infection in MS.
Conclusions
Host HLA-B*07 allele influence EBV VL in MS. As HLA-class I molecules present antigens to T lymphocytes and initiate immune response against viruses, these results could support a role for EBV in MS.