Type II pattern impressively responsive to alemtuzumab
Posted: Tue Apr 03, 2018 4:51 am
They openly speak about a "B-cell driven multiple sclerosis" for the first time, and they identify it to the pattern II.
Rescue therapy with alemtuzumab in B cell/antibody-mediated multiple sclerosis
http://journals.sagepub.com/doi/abs/10. ... 6418759895
Abstract:
Alemtuzumab exerts its clinical efficacy by its specific pattern of depletion and repopulation of different immune cell subsets. Recently, single cases of multiple sclerosis patients who developed severe exacerbation after the first alemtuzumab application, accompanied by re-appearance of peripheral B cells, were reported. Here we present a case with underlying B cell-driven multiple sclerosis that impressively improves after alemtuzumab, although peripheral B cell repopulation took place. Our detailed clinical, histopathological, imaging and immunological data suggest that alemtuzumab can act as an effective rescue treatment in highly active B cell-driven and antibody/complement-mediated multiple sclerosis type II patients.
Full pdf freely available:
http://journals.sagepub.com/doi/pdf/10. ... 6418759895
Rescue therapy with alemtuzumab in B cell/antibody-mediated multiple sclerosis
http://journals.sagepub.com/doi/abs/10. ... 6418759895
Abstract:
Alemtuzumab exerts its clinical efficacy by its specific pattern of depletion and repopulation of different immune cell subsets. Recently, single cases of multiple sclerosis patients who developed severe exacerbation after the first alemtuzumab application, accompanied by re-appearance of peripheral B cells, were reported. Here we present a case with underlying B cell-driven multiple sclerosis that impressively improves after alemtuzumab, although peripheral B cell repopulation took place. Our detailed clinical, histopathological, imaging and immunological data suggest that alemtuzumab can act as an effective rescue treatment in highly active B cell-driven and antibody/complement-mediated multiple sclerosis type II patients.
Full pdf freely available:
http://journals.sagepub.com/doi/pdf/10. ... 6418759895