Inside-out model: supporting papers.
Posted: Wed Jan 30, 2019 2:28 am
The inside-out model is an alternative theoretical model for MS that postulates that something within the neurons is the cause of the later autoimmune attack. I am collecting here some papers that support this model.
Biochemically altered myelin triggers autoimmune demyelination (2018)
http://www.pnas.org/content/early/2018/ ... 5115.short
Early axonal damage in normal appearing white matter in multiple sclerosis (2017)
https://ieeexplore.ieee.org/abstract/document/8037494
Myelin Basic Protein Citrullination in Multiple Sclerosis (2016)
https://link.springer.com/article/10.10 ... 016-1920-2
"This review describes the MBP citrullination and its consequence, as well as offering further support for the “inside-out” hypothesis that MS is primarily a neurodegenerative disease with secondary inflammatory demyelination"
Orexin/hypocretinin in multiple sclerosis and experimental autoimmune encephalomyelitis (2019)
http://www.nrronline.org/article.asp?is ... st=Pallais
Biochemically altered myelin triggers autoimmune demyelination (2018)
http://www.pnas.org/content/early/2018/ ... 5115.short
Early axonal damage in normal appearing white matter in multiple sclerosis (2017)
https://ieeexplore.ieee.org/abstract/document/8037494
Myelin Basic Protein Citrullination in Multiple Sclerosis (2016)
https://link.springer.com/article/10.10 ... 016-1920-2
"This review describes the MBP citrullination and its consequence, as well as offering further support for the “inside-out” hypothesis that MS is primarily a neurodegenerative disease with secondary inflammatory demyelination"
Orexin/hypocretinin in multiple sclerosis and experimental autoimmune encephalomyelitis (2019)
http://www.nrronline.org/article.asp?is ... st=Pallais