This Is MS Multiple Sclerosis Knowledge & Support Community

2019 Aug
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford
Opposing T cell responses in experimental autoimmune encephalomyelitis
https://www.ncbi.nlm.nih.gov/pubmed/31391585

Abstract
Experimental autoimmune encephalomyelitis is a model for multiple sclerosis. Here we show that induction generates successive waves of clonally expanded CD4+, CD8+ and γδ+ T cells in the blood and central nervous system, similar to gluten-challenge studies of patients with coeliac disease. We also find major expansions of CD8+ T cells in patients with multiple sclerosis. In autoimmune encephalomyelitis, we find that most expanded CD4+ T cells are specific for the inducing myelin peptide MOG35-55. By contrast, surrogate peptides derived from a yeast peptide major histocompatibility complex library of some of the clonally expanded CD8+ T cells inhibit disease by suppressing the proliferation of MOG-specific CD4+ T cells. These results suggest that the induction of autoreactive CD4+ T cells triggers an opposing mobilization of regulatory CD8+ T cells.

Here's how to lose me in any MS discussion. Mention EAE. It's not MS, we're not mice. They don't correlate. EAE is given to perfectly healthy mice and they then 'cure' the mice of whatever they gave them to get EAE. Then they publish it as a 'groundbreaking potential MS cure' make a bunch of money and then go infect more mice. The 'cure' never works in people for MS. Most 'cures' aren't even tested beyond mice. There is an entire industry in sickening and then curing them.

Anunymouse wrote: ↑Tue Mar 09, 2021 9:12 am Here's how to lose me in any MS discussion. Mention EAE. It's not MS, we're not mice. They don't correlate. EAE is given to perfectly healthy mice and they then 'cure' the mice of whatever they gave them to get EAE.

The SJL/J mouse used for EAE studies is really screwed up. It develops prolific cancers as well as spontaneous myopathies making it a model for muscular dystrophy. The cancer problem suggests that its immune system is deficient to begin with.

http://www.thisisms.com/forum/general-d ... tml#p12025